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Synthesis, Characterization of Ruthenium Compounds and Studies of Biological Effects in MCF-7 Tumors Cell Lines

DOI: 10.4236/abc.2022.123006, PP. 61-71

Keywords: Ruthenium, MCF-7 Cells, Cytotoxic Evaluation, N-Heterocyclic Ligands

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This work presents the synthesis and characterization of compounds derived from the ruthenium transition metal with the nitrogenous ligand 4-aminopy- ridine (4-ampy). The synthesized compounds were characterized by FTIRmed spectroscopy and TG-DTA thermal analysis. For the cytotoxic evaluation of ruthenium compounds, a 66.0 μM aqueous solution containing the complex and the study of data observed in the biological assessment was performed using variance (ANOVA) analysis, followed by Tukey’s multiple comparisons test. Differences between treatments were considered significant when the p-value was less than 0.05 (p < 0.05). TG/DSC thermal analysis for the first complex suggests a stoichiometry of [Ru(Cl)3(4-ampy)(H2O)2]·1/2H2O, which, due to the low solubility in an aqueous medium, was modified to increase its solubility for biological tests. The analysis of the spectra in the medium infrared region (FTIR) for the complex [Ru(Cl)3(4-ampy)(H2O)2]·1/2H2O, shows displacements of the bands observed at 1625 - 1566 cm1 ν(C=C) e (C=N), indicating that coordination to the


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