氢干预糖尿病的研究进展
Advances in Hydrogen Medicine Intervention in Diabetes Mellitus

DOI: 10.12677/NS.2022.113058, PP. 347-353

Keywords: 氢医学，糖尿病，综述
Hydrogen Medicine, Diabetes, Review

Full-Text   Cite this paper   Add to My Lib

Abstract:

糖尿病是一组因遗传和环境因素共同作用导致的代谢性疾病，是目前全世界最常见的慢性疾病之一，严重威胁着人们的健康。氢医学处于蓬勃发展阶段，氢具有抗炎、抗氧化、抗凋亡以及调节信号通路的作用，近年来已被证实在预防和治疗包括糖尿病在内的多种疾病中发挥着作用。本文主要就氢医学的发展、氢分子的作用及其在糖尿病方面的基础研究和临床研究四个方面进行概述，以期为寻找更为有效的糖尿病辅助治疗方法提供新思路。
Diabetes is a group of metabolic diseases caused by the joint action of heredity and environment. It is one of the most common chronic diseases in the world, and it is a serious threat to people’s health. Hydrogen medicine is in a vigorous development stage. Hydrogen has the effects of anti-inflammatory, anti-oxidation, anti apoptosis and regulating signal pathways. In recent years, hydrogen has been proved to play a role in the prevention and treatment of many diseases including diabetes. At present, hydrogen medicine is in a vigorous development stage. This article mainly summarizes four aspects of the development of hydrogen medicine, the role of hydrogen molecules and their basic research and clinical research in diabetes, so as to provide new ideas for further research on hydrogen in the prevention and treatment of diabetes.

References

[1]	Zhu, Q., Wu, Y., Li, Y., Chen, Z., Wang, L., Xiong, H., Dai, E., Wu, J., Fan, B., Ping, L. and Luo, X. (2018) Positive Effects of Hydrogen-Water Bathing in Patients of Psoriasis and Par-apsoriasis En Plaques. Scientific Reports, 8, Article No. 8051. https://doi.org/10.1038/s41598-018-26388-3
[2]	Long, P., Yan, W., He, M., Zhang, Q., Wang, Z., Li, M., Xue, J., Chen, T., An, J. and Zhang, Z. (2019) Protective Effects of Hydrogen Gas in a Rat Model of Branch Retinal Vein Oc-clusion via Decreasing VEGF-α Expression. BMC Ophthalmology, 19, Article No. 112. https://doi.org/10.1186/s12886-019-1105-2
[3]	Feng, S., Duan, E., Shi, X., Zhang, H., Li, H., Zhao, Y., Chao, L., Zhong, X., Zhang, W., Li, R. and Yan, X. (2019) Hydrogen Ameliorates Lung Injury in a Rat Model of Subacute Expo-sure to Concentrated Ambient PM2.5 via Aryl Hydrocarbon Receptor. International Immunopharmacology, 77, Article ID: 105939. https://doi.org/10.1016/j.intimp.2019.105939
[4]	Akagi, J. and Baba, H. (2019) Hydrogen Gas Restores Ex-hausted CD8+ T Cells in Patients with Advanced Colorectal Cancer to Improve Prognosis. Oncology Reports, 41, 301-311. https://doi.org/10.3892/or.2018.6841
[5]	Hirano, S.I., Aoki, Y., Li, X.K., Ichimaru, N., Takahara, S. and Takefuji, Y. (2021). Protective Effects of Hydrogen Gas Inhalation on Radiation-Induced Bone Marrow Damage in Cancer Patients: A Retrospective Observational Study. Medical Gas Research, 11, 104-109. https://doi.org/10.4103/2045-9912.314329
[6]	Chen, J., Mu, F., Lu, T., Ma, Y., Du, D. and Xu, K. (2019). A Gallbladder Carcinoma Patient with Pseudo-Progressive Remission after Hydrogen Inhalation. OncoTargets and Thera-py, 12, 8645-8651. https://doi.org/10.2147/OTT.S227217
[7]	国家卫生健康委员会. 关于印发新型冠状病毒肺炎诊疗方案(试行第八版)的通知[EB/OL]. http://www.gov.cn/zhengce/zhengceku/2020-08/19/5535757/files/da89edf7cc9244fbb34ecf6c61df40bf.pdf, 2021-07-10.
[8]	Guan, W., Wei, C., Chen, A., Sun, X.C., Guo, G.Y., Zou, X., et al. (2020) Hydrogen/Oxygen Mixed Gas Inhalation Improves Disease Severity and Dyspnea in Patients with Corona Virus Disease 2019 in a Recent Mul-ti-Center, Open-Label Clinical Trial. Journal of Thoracic Disease, 12, 3448-3452. https://doi.org/10.21037/jtd-2020-057
[9]	Hong, Y., Guo, S., Chen, S., Sun, C., Zhang, J. and Sun, X. (2012) Beneficial Effect of Hydrogen-Rich Saline on Cerebral Vasospasm after Experimental Subarachnoid Hemorrhage in Rats. Journal of Neuroscience Research, 90, 1670-1680. https://doi.org/10.1002/jnr.22739
[10]	Lu, Y., Li, C.F., Ping, N.N., Sun, Y.Y., Wang, Z., Zhao, G.X., Yuan, S.H., Zibrila, A.I., Soong, L. and Liu, J.J. (2020) Hydrogen-Rich Water Alleviates Cyclosporine A-Induced Nephrotoxicity via the Keap1/Nrf2 Signaling Pathway. Journal of Biochemical and Molecular Toxicology, 34, Article ID: e22467. https://doi.org/10.1002/jbt.22467
[11]	Li, L., Liu, T., Liu, L., Li, S., Zhang, Z., Zhang, R., Zhou, Y. and Liu, F. (2019) Effect of Hydrogen-Rich Water on the Nrf2/ARE Signaling Pathway in Rats with Myocardial Ischemia-Reperfusion Injury. Journal of Bioenergetics and Biomembranes, 51, 393-402. https://doi.org/10.1007/s10863-019-09814-7
[12]	Li, S.W., Takahara, T., Que, W., Fujino, M., Guo, W.Z., Hirano, S.I., Ye, L.P. and Li, X.K. (2021) Hydrogen-Rich Water Protects against Liver Injury in Nonalcoholic Steatohepatitis Through HO-1 Enhancement via IL-10 and Sirt 1 Signaling. American Journal of Physiology. Gastrointestinal and Liver Physiology, 320, G450-G463. https://doi.org/10.1152/ajpgi.00158.2020
[13]	Zhang, Y., Xu, J., Long, Z., Wang, C., Wang, L., Sun, P., Li, P. and Wang, T. (2016) Hydrogen (H2) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways. Fron-tiers in Pharmacology, 7, Article No. 392. https://doi.org/10.3389/fphar.2016.00392
[14]	李婷, 邓树豪, 雷雯, 李振坤, 吴文娟, 张涛, 董昭兴. 氢气水通过升高Nrf2的表达减轻百草枯诱导的肺纤维化[J]. 南方医科大学学报, 2020, 40(2): 233-239.
[15]	Wang, L., Zhao, C., Wu, S., Xiao, G., Zhuge, X., Lei, P. and Xie, K. (2018) Hydrogen Gas Treatment Improves the Neurological Outcome after Traumatic Brain Injury via Increasing MiR-21 Expression. Shock, 50, 308-315. https://doi.org/10.1097/SHK.0000000000001018
[16]	Li, J., Hong, Z., Liu, H., Zhou, J., Cui, L., Yuan, S., Chu, X. and Yu, P. (2016) Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in Rats via Anti-Apoptosis and Anti-Inflammation. Frontiers in Pharmacology, 7, Article No. 106. https://doi.org/10.3389/fphar.2016.00106
[17]	Tao, G., Song, G. and Qin, S. (2019) Molecular Hydrogen: Current Knowledge on Mechanism in Alleviating Free Radical Damage and Diseases. Acta Biochimica et Biophysica Sinica, 51, 1189-1197. https://doi.org/10.1093/abbs/gmz121
[18]	Chen, O., Cao, Z., Li, H., Ye, Z., Zhang, R., Zhang, N., Huang, J., Zhang, T., Wang, L., Han, L., Liu, W. and Sun, X. (2017) High-Concentration Hydrogen Protects Mouse Heart against Ischemia/reperfusion Injury Through Activation of ThePI3K/Akt1 Pathway. Scientific Reports, 7, Article No. 14871. https://doi.org/10.1038/s41598-017-14072-x
[19]	Wu, J., Wang, R., Yang, D., Tang, W., Chen, Z., Sun, Q., Liu, L. and Zang, R. (2018) Hydrogen Postconditioning Promotes Survival of Rat Retinal Ganglion Cells against Ische-mia/Reperfusion Injury Through the PI3K/Akt Pathway. Biochemical and Biophysical Research Communications, 495, 2462-2468. https://doi.org/10.1016/j.bbrc.2017.12.146
[20]	Heald, A.H., Stedman, M., Davies, M., Livingston, M., Alshames, R., Lunt, M., Rayman, G. and Gadsby, R. (2020) Es-timating Life Years Lost to Diabetes: Outcomes from Analysis of National Diabetes Audit and Office of National Statis-tics Data. Cardiovascular Endocrinology & Metabolism, 9, 183-185. https://doi.org/10.1097/XCE.0000000000000210
[21]	Wu, D., Liang, M., Dang, H., Fang, F., Xu, F. and Liu, C. (2018) Hydrogen Protects against Hyperoxia-Induced Apoptosis in Type II Alveolar Epithelial Cells via Activa-tion of PI3K/Akt/Foxo3a Signaling Pathway. Biochemical and Biophysical Research Communications, 495, 1620-1627. https://doi.org/10.1016/j.bbrc.2017.11.193
[22]	Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurt-sova, K., Duncan, B.B., Stein, C., Basit, A., Chan, J., Mbanya, J.C., Pavkov, M.E., Ramachandaran, A., Wild, S.H., James, S., Herman, W.H., Zhang, P., Bommer, C., Kuo, S., Boyko, E.J. and Magliano, D.J. (2022) IDF Diabetes Atlas: Global, Regional and Country-Level Diabetes Prevalence Estimates for 2021 and Projections for 2045. Diabetes Re-search and Clinical Practice, 183, Article ID: 109119. https://doi.org/10.1016/j.diabres.2021.109119
[23]	中华医学会糖尿病分会. 2020年版中国2型糖尿病防治指南[J]. 中华内分泌代谢杂志, 2021, 37(4): 311-398.
[24]	Wang, Q.J., Zha, X.J., Kang, Z.M., Xu, M.J., Huang, Q. and Zou, D.J. (2012) Therapeutic Effects of Hydrogen Saturated Saline on Rat Diabetic Model and Insulin Resistant Model via Reduction of Oxidative Stress. Chinese Medical Journal, 125, 1633-1637.
[25]	Zhang, X., Liu, J., Jin, K., Xu, H., Wang, C., Zhang, Z., Kong, M., Zhang, Z., Wang, Q. and Wang, F. (2018) Subcutaneous Injection of Hydrogen Gas Is a Novel Effective Treatment for Type 2 Diabetes. Journal of Diabetes Investigation, 9, 83-90. https://doi.org/10.1111/jdi.12674
[26]	Shirahata, S., Hamasaki, T., Haramaki, K., Nakamura, T., Abe, M., Yan, H., Kinjo, T., Nakamichi, N., Kabayama, S. and Teruya, K. (2011) Anti-Diabetes Effect of Water Containing Hydrogen Molecule and Pt Nanoparticles. BMC Proceedings, 5, Article No. P18. https://doi.org/10.1186/1753-6561-5-S8-P18
[27]	Xiao, X., Cai, J., Xu, J., Wang, R., Cai, J., Liu, Y., Xu, W., Sun, X. and Li, R. (2012) Protective Effects of Hydrogen Saline on Diabetic Retinopathy in a Streptozotocin-Induced Diabetic Rat Model. Journal of Ocular Pharmacology and Therapeutics, 28, 76-82. https://doi.org/10.1089/jop.2010.0129
[28]	Feng, Y., Wang, R., Xu, J., Sun, J., Xu, T., Gu, Q. and Wu, X. (2013) Hydrogen-Rich Saline Prevents Early Neurovascular Dysfunction Resulting from Inhibition of Oxidative Stress in STZ-Diabetic Rats. Current Eye Research, 38, 396-404. https://doi.org/10.3109/02713683.2012.748919
[29]	刘国丹, 韩清, 高翔春, 王进, 田苗. 分子氢对糖尿病视网膜小胶质细胞的保护作用及其机制研究[J]. 现代生物医学进展, 2016, 16(26): 5015-5018.
[30]	焦洋, 于洋, 李波, 于泳浩. 富氢液对大鼠早期糖尿病神经痛的影响[J]. 中华麻醉学杂志, 2014, 34(4): 423-426.
[31]	李德东, 李波, 孙健, 张素品, 于泳浩, 吕国义. 富氢液对糖尿病神经痛大鼠外周神经Nrf2/ARE 通路的影响[J]. 中华麻醉学杂志, 2015, 35(12): 1456-1459.
[32]	Fan, M., Xu, X., He, X., Chen, L., Qian, L., Liu, J., Qing, J., Chao, Z. and Sun, X. (2013) Protective Effects of Hydrogen-Rich Saline against Erectile Dysfunction in a Streptozotocin Induced Diabetic Rat Model. The Journal of Urology, 190, 350-356. https://doi.org/10.1016/j.juro.2012.12.001
[33]	Wu, F., Qiu, Y., Ye, G., Luo, H., Jiang, J., Yu, F., Zhou, W., Zhang, S. and Feng, J. (2015) Treatment with Hydrogen Molecule Attenuates Cardiac Dysfunction in Streptozoto-cin-Induced Diabetic Mice. Cardiovascular Pathology, 24, 294-303. https://doi.org/10.1016/j.carpath.2015.04.008
[34]	Guo, J., Dong, W., Jin, L., Wang, P., Hou, Z. and Zhang, Y. (2017) Hydrogen-Rich Saline Prevents Bone Loss in Diabetic Rats Induced by Streptozotocin. International Orthopae-dics, 41, 2119-2128. https://doi.org/10.1007/s00264-017-3581-4
[35]	Kajiyama, S., Hasegawa, G., Asano, M., Hood, H., Fukui, M., Nakamura, N., Kitawaki, J., Imai, S., Nakano, K., Ohta, M., Adachi, T., Obayashi, H. and Yoshikawa, T. (2008) Sup-plementation of Hydrogen-Rich Water Improves Lipid and Glucose Metabolism in Patients with Type 2 Diabetes or Im-paired Glucose Tolerance. Nutrition Research, 28, 137-143. https://doi.org/10.1016/j.nutres.2008.01.008
[36]	Ogawa, S., Ohsaki, Y., Shimizu, M., Nako, K., Okamura, M., Kabayama, S., Tabata, K., Tanaka, Y. and Ito, S. (2021) Electrolyzed Hydrogen-Rich Water for Oxidative Stress Sup-pression and Improvement of Insulin Resistance: A Multicenter Prospective Double-Blind Randomized Control Trial. Diabetology International, 13, 209-219. https://doi.org/10.1007/s13340-021-00524-3
[37]	Dole, M., Wilson, F.R. and Fife, W.P. (1975) Hyperbaric Hy-drogen Therapy: A Possible Treatment for Cancer. Science, 190, 152-154. https://doi.org/10.1126/science.1166304
[38]	Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., Katsura, K., Katayama, Y., Asoh, S. and Ohta, S. (2007) Hydrogen Acts as a Therapeutic Antioxidant by Selectively Reducing Cytotoxic Oxygen Radicals. Nature Medicine, 13, 688-694. https://doi.org/10.1038/nm1577
[39]	Ono, H., Nishijima, Y., Ohta, S., Sakamoto, M., Kinone, K., Horikosi, T., Tamaki, M., Takeshita, H., Futatuki, T., Ohishi, W., Ishiguro, T., Okamoto, S., Ishii, S. and Takanami, H. (2017) Hy-drogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection. Journal of Stroke and Cerebrovascular Diseases, 26, 2587-2594. https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.06.012
[40]	Korovljev, D., Stajer, V., Ostojic, J., LeBaron, T.W. and Ostojic, S.M. (2019) Hydrogen-Rich Water Reduces Liver Fat Accumulation and Improves Liver Enzyme Pro-files in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Pilot Trial. Clinics and Research in Hepatology and Gastroenterology, 43, 688-693. https://doi.org/10.1016/j.clinre.2019.03.008
[41]	Pirttil？, K., Videhult Pierre, P., Hagl？f, J., Engskog, M., Hedeland, M., Laurell, G., Arvidsson, T. and Pettersson, C. (2019) An LCMS-Based Untargeted Metabolomics Protocol for Cochlear Perilymph: Highlighting Metabolic Effects of Hydrogen Gas on the Inner Ear of Noise Exposed Guinea Pigs. Metabolomics, 15, Article No. 138. https://doi.org/10.1007/s11306-019-1595-1
[42]	Nishimaki, K., Asada, T., Ohsawa, I., Nakajima, E., Ikejima, C., Yokota, T., Kamimura, N. and Ohta, S. (2018) Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. Current Alzheimer Research, 15, 482-492. https://doi.org/10.2174/1567205014666171106145017
[43]	Lee, J., Yang, G., Kim, Y.J., Tran, Q.H., Choe, W., Kang, I., Kim, S.S. and Ha, J. (2017) Hydrogen-Rich Medium Protects Mouse Embryonic Fibroblasts from Oxidative Stress by Acti-vating LKB1-AMPK-FoxO1 Signal Pathway. Biochemical and Biophysical Research Communications, 491, 733-739. https://doi.org/10.1016/j.bbrc.2017.07.119
[44]	LeBaron, T.W., Singh, R.B., Fatima, G., Kartikey, K., Sharma, J.P., Ostojic, S.M., Gvozdjakova, A., Kura, B., Noda, M., Mojto, V., Niaz, M.A. and Slezak, J. (2020) The Ef-fects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflamma-tion Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 13, 889-896. https://doi.org/10.2147/DMSO.S240122

Full-Text