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慢性低氧暴露对认知功能影响的研究进展
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Abstract:
高原地区以低压、低氧、寒冷干燥的自然环境区别于平原地区，久居高原者会发生大脑结构的病理性改变，进而造成认知等高级脑功能的损害。近些年来，高原环境对脑功能的影响逐渐引起高原医学界学者的关注，但高原长期低氧环境引起的脑结构与功能改变尚缺乏系统认识。因此，积极寻找长期高原低氧环境下认知损伤可能的发病机制，对延缓高原久居者认知损伤的发生及进展有重要意义。本文就近年来长期高原慢性低氧环境对认知功能的影响作一总结，以期为其临床诊治提供参考。
The natural environment of low pressure, low oxygen, cold and dry in the plateau region is different from that in the plain area. People living on the plateau for a long time will have pathological changes in brain structure, resulting in cognitive impairment and other higher brain functions. In recent years, the influence of plateau environment on brain function has gradually attracted the attention of plateau medical scholars, but the changes of brain structure and function caused by plateau long-term hypoxia environment are still not systematically understood. Therefore, it is of great significance to actively explore the possible pathogenesis of cognitive impairment under the long-term high altitude and low oxygen environment, so as to delay the occurrence and progression of cognitive impairment in people living at high altitude for a long time. This paper summarizes the effects of chronic hypoxic environment on cognitive function in recent years, in order to provide reference for clinical diagnosis and treatment
| [1] | 韩培, 张强, 童丽, 刘彦民, 罗玮, 王勃, 王伟, 宋仁君, 宋康, 吕凌. 青海省高原转化医学现状及存在问题[J]. 青海科技, 2021, 28(6): 80-86. |
| [2] | Hu, S.L., Xiong, W., Dai, Z.Q., Zhao, H.L. and Feng, H. (2017) Cognitive Chang-es during Prolonged Stay at High Altitude and Its Correlation with C-Reactive Protein. PLOS ONE, 11, e0146290.
https://doi.org/10.1371/journal.pone.0146290 |
| [3] | 费尔立, 顾耘, 黄凯, 潘露茜. 小胶质细胞功用在认知功能障碍中的研究进展[J]. 中国中医药现代远程教育, 2021, 19(2): 199-202. |
| [4] | 高伊星. 久居高原青年官兵脑功能的变化特征及其相关因素研究[D]: [硕士学位论文]. 重庆: 第三军医大学, 2013. |
| [5] | 马薛欣雨, 杨晓娟, 杨志福, 王剑波, 张粉红, 曹金一. 高原暴露下认知功能障碍的研究进展[J]. 中国实用神经疾病杂志, 2021, 24(21): 1924-1932. |
| [6] | Guo, M., Ma, X., Feng, Y., Han, S., Dong, Q., Cui, M. and Zhao, Y. (2019) In Chronic Hypoxia, Glucose Availability and Hypoxic Severity Dictate the Balance between HIF-1 and HIF-2 in Astrocytes. The FASEB Journal, 33, 11123-11136. https://doi.org/10.1096/fj.201900402RR |
| [7] | Zhang, J., Yan, X., Shi, J., Gong, Q., Weng, X. and Liu, Y. (2017) Structural Modifications of the Brain in Acclimatization to High-Altitude. PLOS ONE, 5, e11449. https://doi.org/10.1371/journal.pone.0011449 |
| [8] | Bao, H., He, X., Wang, F. and Kang, D. (2022) Study of Brain Structure and Function in Chronic Mountain Sickness Based on fMRI. Frontiers in Neurology, 12, Article ID: 763835. https://doi.org/10.3389/fneur.2021.763835 |
| [9] | 吉维忠, 张亚清, 格日力. 慢性低压低氧暴露对大鼠学习记忆能力及神经元凋亡水平的影响[J]. 中华老年心脑血管病杂志, 2021, 23(3): 301-305. |
| [10] | Ma, H., Wang, Y., Wu, J., Wang, B., Guo, S., Luo, P. and Han, B. (2015) Long-Term Exposure to High Altitude Affects Conflict Con-trol in the Conflict-Resolving Stage. PLOS ONE, 10, e0145246.
https://doi.org/10.1371/journal.pone.0145246 |
| [11] | 刘莉, 孙俊, 周晓斌, 张娴. 高海拔地区武警男性官兵高尿酸血症的调查及因素分析[J]. 武警后勤学院学报(医学版), 2019, 28(8): 39-42. https://doi.org/10.16548/j.2095-3720.2019.08.009 |
| [12] | 杨全玉, 李强, 王向阳, 刘诗翔. 高原性红细胞增多症官兵睡眠质量和认知功能调查[J]. 郑州大学学报(医学版), 2011, 46(3): 476-477. https://doi.org/10.13705/j.issn.1671-6825.2011.03.065 |
| [13] | 王铎尧, 鲍海华, 赵希鹏, 李文方. 慢性高原病脑部CT表现与血红蛋白含量的对照研究[J]. 青海医学院学报, 2010, 31(1): 32-35. https://doi.org/10.13452/j.cnki.jqmc.2010.01.016 |
| [14] | Swenson, E.R. (2016) Pharmacology of Acute Mountain Sickness: Old Drugs and Newer Thinking. Journal of Applied Physiology (Bethesda, Md.: 1985), 120, 204-215. https://doi.org/10.1152/japplphysiol.00443.2015 |
| [15] | Berger, H.R., Nyman, A.K.G., Morken, T.S., Vettukattil, R., Brubakk, A.-M. and Wider？e, M. (2017) Early Metabolite Changes after Melatonin Treatment in Neonatal Rats with Hypoxic-Ischemic Brain Injury Studied by in-Vivo 1H MR Spectroscopy. PLOS ONE, 12, e0185202. https://doi.org/10.1371/journal.pone.0185202 |
| [16] | Mirdamadi, J.L. (2016) Cerebellar Role in Parkinson’s Disease. Journal of Neurophysiology, 116, 917-919.
https://doi.org/10.1152/jn.01132.2015 |
| [17] | Maiti, P., Singh, S.B., Sharma, A.K., Muthuraju, S., Banerjee, P.K. and Ilavazhagan, G. (2006) Hypobaric Hypoxia Induces Oxidative Stress in Rat Brain. Neurochemistry International, 49, 709-716.
https://doi.org/10.1016/j.neuint.2006.06.002 |
| [18] | Ataizi, Z.S., Ertilav, K. and Naz？ro？lu, M. (2019) Mitochondrial Oxidative Stress-Induced Brain and Hippocampus Apoptosis Decrease through Modulation of Caspase Activity, Ca2+ Influx and Inflammatory Cytokine Molecular Pathways in the Docetaxel-Treated Mice by Melatonin and Selenium Treatments. Metabolic Brain Disease, 34, 1077-1089. https://doi.org/10.1007/s11011-019-00428-x |
| [19] | 胡科妍, 史清海, 伏建峰. 急进高原大脑认知功能障碍的机制及其防护措施[J]. 西北国防医学杂志, 2015, 36(4): 247-250. https://doi.org/10.16021/j.cnki.1007-8622.2015.04.013 |
| [20] | 吉维忠, 吴世政. 高原低氧环境诱导认知功能损害研究现况[J]. 中国高原医学与生物学杂志, 2019, 40(3): 189-193. https://doi.org/10.13452/j.cnki.jqmc.2019.03.009 |
| [21] | Rohm, I., Ratka, J., Pistulli, R., Goebel, B., Gecks, T., Fig-ulla, H.R., Yilmaz, A. and Jung, C. (2015) Impact of Systemic Normobaric Short-Term Hypoxia on Pro-Inflammatory and Anti-Inflammatory Cytokines in Healthy Volunteers. Clinical Laboratory, 61, 1053-1059. https://doi.org/10.7754/Clin.Lab.2015.141226 |
| [22] | Beck-Schimmer, B., Schimmer, R.C., Madjdpour, C., Bonvini, J.M., Pasch, T. and Ward, P.A. (2001) Hypoxia Mediates Increased Neutrophil and Macrophage Adhesiveness to Alve-olar Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology, 25, 780-787. https://doi.org/10.1165/ajrcmb.25.6.4433 |
| [23] | Zhou, Y., Huang, X., Zhao, T., Qiao, M., Zhao, X., Zhao, M., Xu, L., Zhao, Y., Wu, L., Wu, K., Chen, R., Fan, M. and Zhu, L. (2017) Hypoxia Augments LPS-Induced Inflammation and Triggers High Altitude Cerebral Edema in Mice. Brain, Behavior and Immunity, 64, 266-275. https://doi.org/10.1016/j.bbi.2017.04.013 |
| [24] | Ito, H., Yamamoto, N., Arima, H., Hirate, H., Morishima, T., Umenishi, F., Tada, T., Asai, K., Katsuya, H. and Sobue, K. (2006) Interleukin-1β Induces the Expression of Aqua-porin-4 through a Nuclear Factor-κB Pathway in Rat Astrocytes. Journal of Neurochemistry, 99, 107-118. https://doi.org/10.1111/j.1471-4159.2006.04036.x |
| [25] | Yang, Y., Estrada, E.Y., Thompson, J.F., Liu, W. and Rosenberg, G.A. (2007) Matrix Metalloproteinase-Mediated Disruption of Tight Junction Proteins in Cerebral Vessels Is Reversed by Synthetic Matrix Metalloproteinase Inhibitor in Focal Ischemia in Rat. Journal of Cerebral Blood Flow & Metabolism, 27, 697-709.
https://doi.org/10.1038/sj.jcbfm.9600375 |
| [26] | Natah, S.S., Srinivasan, S., Pittman, Q., Zhao, Z. and Dunn, J.F. (2009) Effects of Acute Hypoxia and Hyperthermia on the Permeability of the Blood-Brain Barrier in Adult Rats. Journal of Applied Physiology (Bethesda, Md.: 1985), 107, 1348-1356. https://doi.org/10.1152/japplphysiol.91484.2008 |
| [27] | Revah, O., Lasser-Katz, E., Fleidervish, I.A. and Gutnick, M.J. (2016) The Earliest Neuronal Responses to Hypoxia in the Neocortical Circuit Are Glutamate-Dependent. Neurobi-ology of Disease, 95, 158-167.
https://doi.org/10.1016/j.nbd.2016.07.019 |
| [28] | Bradi, A.C., Faughnan, M.E., Stanbrook, M.B., Deschenes-Leek, E. and Chapman, K.R. (2009) Predicting the Need for Supplemental Oxygen during Airline Flight in Patients with Chronic Pulmonary Disease: A Comparison of Predictive Equations and Altitude Simulation. Canadian Respiratory Journal, 16, Article ID: 371901.
https://doi.org/10.1155/2009/371901 |
| [29] | Muthuraju, S., Maiti, P., Solanki, P., Sharma, A.K., Singh, S.B., Prasad. D. and Ilavazhagan, G. (2010) Cholinesterase Inhibitors Ameliorate Spatial Learning Deficits in Rats Following Hypo-baric Hypoxia. Experimental Brain Research, 203, 583-592. https://doi.org/10.1007/s00221-010-2266-7 |
| [30] | Muthuraju, S., Maiti, P., Pati, S., Solanki, P., Sharma, A.K., Singh, S.B., Prasad, D. and Ilavazhagan, G. (2011) Role of Cholinergic Markers on Memory Function of Rats Exposed to Hypobaric Hypoxia. European Journal of Pharmacology, 672, 96-105. https://doi.org/10.1016/j.ejphar.2011.08.023 |
| [31] | 刘成娟, 黄盛洁, 杜瑞姣, 李彤, 姜苗苗. 基于CiteSpace对红景天研究进展的可视化分析[J]. 中南药学, 2022, 20(5): 1192-1197. |
| [32] | 陈刚, 周海娟. 黄芪当归合剂对大鼠脑缺血再灌注后神经细胞凋亡及内质网应激的影响[J]. 中医学报, 2019, 34(8): 1709-1714. https://doi.org/10.16368/j.issn.1674-8999.2019.08.403 |
| [33] | Nisha, S.N., Fathinul Fikri, A.S., Aida, A.R., Salasiah, M., Hamed, S., Rohit, T., Amei Farina, A.R., Loh, J.L., Mazlyfarina, M. and Subapriya, S. (2020) The Objective As-sessment of the Effects on Cognition Functioning among Military Personnel Exposed to Hypobaric-Hypoxia: A Pilot fMRI Study. The Medical Journal of Malaysia, 75, 62-67. |
