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心脏重编程相关机制研究进展
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Abstract:
心肌梗死占心血管疾病死亡率的50%。由于梗死部位发生纤维化重塑，在急性心肌梗死中幸存下来的人有着心力衰竭的显著风险。传统治疗方法可改善心脏血供，无法使已经受损的心肌细胞再生，而心脏再生医学的兴起为心肌梗死的治疗提供了新出路。心脏重编程可增加功能性心肌细胞数量并且减少心肌梗死后纤维化面积。本文主要介绍心脏直接重编程方法和相关机制研究，尤其是关于心脏重编程相关机制的研究进展。
Myocardial infarction accounts for 50% of the mortality of cardiovascular diseases. People who sur-vive an acute myocardial infarction are at significant risk of heart failure due to fibrotic remodeling at the infarct site. Traditional treatment methods can improve the blood supply to the heart, but cannot regenerate damaged myocardial cells. However, the rise of cardiac regenerative medicine provides a new way for the treatment of myocardial infarction. Cardiac reprogramming increases the number of functional cardiomyocytes and reduces the area of fibrosis after myocardial infarc-tion. This paper mainly introduces the methods and mechanisms of cardiac direct reprogramming, especially the research progress on the mechanisms of cardiac reprogramming.
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