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循环肿瘤细胞对结直肠癌临床诊疗的研究进展
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Abstract:
近年来全球结直肠癌的发病率和死亡率均呈明显增长。结直肠癌在确诊时，大部分已是中晚期，治疗效果及患者的预后均不理想；现阶段临床上诊断结直肠癌还是依靠肿瘤标记物的监测以及CT、MRI、结肠镜等影像学检查，这些检查或灵敏度欠佳，或对患者自身创伤较大，或是不能随时监测疾病进展。有研究显示循环肿瘤细胞可用于诊断早期结直肠癌、评估结直肠癌诊疗效果以及监测癌症转移和预后等。笔者就循环肿瘤细胞对结直肠癌临床诊疗的全球研究进展作了综述，这对临床参考价值极大。
In recent years, the incidence and mortality of colorectal cancer have increased significantly world-wide. When colorectal cancer is diagnosed, most of it is in the middle and advanced stage, and the treatment effect and prognosis of patients are not ideal. At the present stage, the clinical diagnosis of colorectal cancer still relies on the monitoring of tumor markers and imaging examinations such as CT, MRI and colonoscopy. These examinations are not sensitive enough, or have great trauma to the patients themselves, or cannot monitor the progress of the disease at any time. Studies have shown that circulating tumor cells can be used to diagnose early colorectal cancer, evaluate the therapeutic effect of colorectal cancer, and monitor cancer metastasis and prognosis. This paper re-views the global research progress of circulating tumor cells in clinical diagnosis and treatment of colorectal cancer, which has great clinical reference value.
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