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CTHRC1在消化道肿瘤侵袭及转移中的作用研究进展
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Abstract:
胶原三股重叠螺旋蛋白(CTHRC1)作为一种稳定分泌性糖蛋白，发挥着诸多生物学功能，其中包括有创动脉血管修复、骨重建、脂肪组织形成等良性病变，且已被证实为肿瘤动态演变相关联基因之一。目前研究表明，CTHRC1在大多数人体实体肿瘤中呈现异常表达，通过不同的分子机制和信号转导通路介导肿瘤侵袭和转移。本文就CTHRC1在消化道肿瘤领域的侵袭和转移研究成果进行综述，为临床疾病的诊治提供医学理论。
Collagen triple overlapping helix protein (CTHRC1) is a stable secretory glycoprotein. It plays many biological functions, including invasive vascular repair, bone remodeling, adipose tissue formation and more. It has been confirmed as one of the genes related to the dynamic evolution of tumor. It has been showed that CTHRC1 has abnormal expression in most solid tumors and mediates tumor invasion and metastasis through different molecular mechanisms and signal pathways. This article reviews the research on the invasion and metastasis of CTHRC1 in gastrointestinal tumors in order to provide evidence for the diagnosis and treatment of clinical diseases.
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