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PI3K/AKT信号通路在缺血性脑卒中中的保护作用
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Abstract:
脑梗死的高发病率、高死亡率、高致残率和高复发率，为人类的生命健康带来了极大的危害，其损伤机制包括细胞凋亡、钙超载、活性氧过度生成、炎症反应和兴奋性氨基酸毒性作用等多种复杂病理机制。PI3K/AKT信号通路作为近些年研究较多的信号通路之一，与缺血性脑卒中的发生发展密切相关。本文就近些年PI3K/AKT信号通路在缺血性脑卒中中的作用机制进行综述，为探索缺血性脑卒中诊疗提供新的思路。
High incidence, high mortality, high disability and high recurrence rates of cerebral infarction have brought great harm to human life and health, and its injury mechanism involves a variety of com-plex pathological mechanisms, including apoptosis, calcium overload, excessive production of reac-tive oxygen species, inflammatory reaction and toxic effects of excitatory amino acids. As one of the most studied signaling pathways in recent years, PI3K/AKT signaling pathway is closely related to the occurrence and development of ischemic stroke. This paper reviews the mechanism of PI3K/AKT signaling pathway in ischemic stroke in recent years, providing new ideas for exploring the diagnosis and treatment of ischemic stroke.
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