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晚期胃癌治疗的研究进展与未来方向
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Abstract:
中国是胃癌高发国家，其中晚期患者占比高，生存率低。近年来，胃癌领域免疫治疗的研究成为主流方向，主要是程序性死亡受体(PD-1)等免疫检查点抑制剂，为胃癌的治疗打开了新世界的大门。随着肿瘤分子生物学的不断深入，越来越多的新靶点不断被发现，随之出现的新药物也给晚期胃癌的治疗带来了新的方向。本文将对目前临床前实验、临床试验的数据进行分析整理对晚期胃癌免疫治疗、靶向治疗等研究进展进行综述，并简单阐述晚期胃癌治疗的未来探索方向。
China is a country with a high incidence of gastric cancer, in which the proportion of advanced pa-tients is high and the survival rate is low. In recent years, the research of immunotherapy in gastric cancer has become the main direction, mainly PD-1 and other immune checkpoint inhibitors, which opens a new world for the treatment of gastric cancer. With the development of tumor molecular biology, more and more new targets have been found, and the new drugs have brought new oppor-tunities for the treatment of advanced gastric cancer. In this paper, the data of preclinical and clini-cal trials are analyzed and integrated, and the research progress of immunotherapy and targeted therapy for advanced gastric cancer is reviewed. The future directions of the treatment of advanced gastric cancer were also briefly discussed.
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