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老年人衰弱与认知障碍之间的联系
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Abstract:
随着年龄的增长，在老年人中，衰弱和认知障碍越来越普遍，也逐渐提出了认知衰弱这一新概念，可见，衰弱和认知障碍之间存在一定的联系，本文旨在对老年人衰弱和认知障碍的发生机制、危险因素及两者之间的关系做出综述，希望能为探索衰弱和认知障碍提供新思路，也为有效预防衰弱和认知障碍提供帮助。
Frailty and cognitive impairment are becoming more common in the elderly with increasing age. Also gradually put forward the cognitive frailty, a new concept, so there is a certain relationship between frailty and cognitive impairment, the purpose of this paper is to make a review for the re-lationship between the elderly frailty and the occurrence mechanism of cognitive impairment, risk factors, hoping to provide new thinking for exploring frailty and cognitive impairment, and provide help to effectively prevent frailty, and cognitive impairment.
| [1] | Dent, E., et al. (2019) Management of Frailty: Opportunities, Challenges, and Future Directions. The Lancet, 394, 1376-1386. https://doi.org/10.1016/S0140-6736(19)31785-4 |
| [2] | 李洁, 赵静华. 认知障碍老年人衰弱的研究进展[J]. 护理学杂志, 2021, 36(15): 106-110. |
| [3] | Sharifi, F., et al. (2021) Studying the Relationship between Cogni-tive Impairment and Frailty Phenotype: A Cross- Sectional Analysis of the Bushehr Elderly Health (BEH) Program. Journal of Diabetes & Metabolic Disorders, 20, 1229-1237. https://doi.org/10.1007/s40200-021-00847-7 |
| [4] | Xue, Q.L., et al. (2019) Integrating Frailty and Cognitive Phe-notypes: Why, How, Now What? Current Geriatrics Reports, 8, 97-106. https://doi.org/10.1007/s13670-019-0279-z |
| [5] | Borges, M.K., et al. (2019) Frailty as a Predictor of Cognitive Disorders: A Systematic Review and Meta-Analysis. Frontiers in Medicine (Lausanne), 6, Article No. 26. https://doi.org/10.3389/fmed.2019.00026 |
| [6] | Paganini-Hill, A., et al. (2001) Clock Drawing: Analysis in a Re-tirement Community. Journal of the American Geriatrics Society, 49, 941-947. https://doi.org/10.1046/j.1532-5415.2001.49185.x |
| [7] | Kelaiditi, E., et al. (2013) Cognitive Frailty: Rational and Definition from an (I.A.N.A./I.A.G.G.) International Consensus Group. The Journal of Nutrition, Health and Aging, 17, 726-734. https://doi.org/10.1007/s12603-013-0367-2 |
| [8] | Drame, M., et al. (2011) Rapid Cognitive Decline, One-Year Institutional Admission and One-Year Mortality: Analysis of the Ability to Predict and Inter-Tool Agreement of Four Validated Clinical Frailty Indexes in the SAFEs Cohort. The Journal of Nutrition, Health and Aging, 15, 699-705. https://doi.org/10.1007/s12603-011-0164-8 |
| [9] | Tay, L., et al. (2016) The Independent Role of Inflam-mation in Physical Frailty among Older Adults with Mild Cognitive Impairment and Mild-to-Moderate Alzheimer’s Dis-ease. The Journal of Nutrition, Health and Aging, 20, 288-299.
https://doi.org/10.1007/s12603-015-0617-6 |
| [10] | Mocchegiani, E., Corsonello, A. and Lattanzio, F. (2010) Frailty, Ageing and Inflammation: Reality and Perspectives. Biogerontology, 11, 523-525. https://doi.org/10.1007/s10522-010-9299-y |
| [11] | Franceschi, C., et al. (2000) Inflamm-Aging. An Evolutionary Perspective on Immunosenescence. Annals of the New York Academy of Sciences, 908, 244-254. https://doi.org/10.1111/j.1749-6632.2000.tb06651.x |
| [12] | Salvioli, S., et al. (2006) Inflamm-Aging, Cytokines and Aging: State of the Art, New Hypotheses on the Role of Mitochondria and New Perspectives from Systems Biology. Current Pharmaceutical Design, 12, 3161-3171.
https://doi.org/10.2174/138161206777947470 |
| [13] | Giunta, S. (2008) Exploring the Complex Relations between Inflammation and Aging (Inflamm-Aging): Anti-Inflamm- Aging Remodelling of Inflamm-Aging, from Robustness to Frailty. Inflammation Research, 57, 558-563.
https://doi.org/10.1007/s00011-008-7243-2 |
| [14] | Darvin, K., et al. (2014) Plasma Protein Biomarkers of the Geriat-ric Syndrome of Frailty. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 69, 182-186. https://doi.org/10.1093/gerona/glt183 |
| [15] | Collerton, J., et al. (2012) Frailty and the Role of Inflammation, Im-munosenescence and Cellular Ageing in the Very Old: Cross-Sectional Findings from the Newcastle 85+ Study. Mecha-nisms of Ageing and Development, 133, 456-466.
https://doi.org/10.1016/j.mad.2012.05.005 |
| [16] | Perry, R.T., et al. (2001) The Role of TNF and Its Receptors in Alzheimer’s Disease. Neurobiology of Aging, 22, 873-883.
https://doi.org/10.1016/S0197-4580(01)00291-3 |
| [17] | Cappola, A.R., Xue, Q.L. and Fried, L.P. (2009) Multiple Hormonal Deficiencies in Anabolic Hormones Are Found in Frail Older Women: The Women’s Health and Aging Stud-ies. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 64, 243-248. https://doi.org/10.1093/gerona/gln026 |
| [18] | Yeap, B.B., et al. (2013) Associations of Insulin-Like Growth Factor-I and Its Binding Proteins and Testosterone with Frailty in Older Men. Clinical Endocrinology (Oxford), 78, 752-759. https://doi.org/10.1111/cen.12052 |
| [19] | Mustafa, A., et al. (1999) Decreased Plasma Insulin-Like Growth Factor-I Level in Familial Alzheimer’s Disease Patients Carrying the Swedish APP 670/671 Mutation. Dementia and Geriatric Cognitive Disorders, 10, 446-451.
https://doi.org/10.1159/000017188 |
| [20] | Watanabe, T., et al. (2005) Relationship between Serum Insulin-Like Growth Factor-1 Levels and Alzheimer’s Disease and Vascular Dementia. Journal of the American Geriatrics Society, 53, 1748-1753.
https://doi.org/10.1111/j.1532-5415.2005.53524.x |
| [21] | Cappola, A.R., et al. (2003) Insulin-Like Growth Factor I and Interleukin-6 Contribute Synergistically to Disability and Mortality in Older Women. The Journal of Clinical Endo-crinology and Metabolism, 88, 2019-2025.
https://doi.org/10.1210/jc.2002-021694 |
| [22] | Leng, S.X., et al. (2004) Serum Levels of Insulin-Like Growth Fac-tor-I (IGF-I) and Dehydroepiandrosterone Sulfate (DHEA-S), and Their Relationships with Serum Interleukin-6, in the Geriatric Syndrome of Frailty. Aging Clinical and Experimental Research, 16, 153-157. https://doi.org/10.1007/BF03324545 |
| [23] | Baylis, D., et al. (2014) Inflammation, Telomere Length, and Grip Strength: A 10-Year Longitudinal Study. Calcified Tissue International, 95, 54-63. https://doi.org/10.1007/s00223-014-9862-7 |
| [24] | Park, D.C. and Reuter-Lorenz, P. (2009) The Adaptive Brain: Aging and Neurocognitive Scaffolding. Annual Review of Psychology, 60, 173-196. https://doi.org/10.1146/annurev.psych.59.103006.093656 |
| [25] | Rinaldi, P., et al. (2003) Plasma Antioxidants Are Similarly Depleted in Mild Cognitive Impairment and in Alzheimer’s Disease. Neurobiology of Aging, 24, 915-919. https://doi.org/10.1016/S0197-4580(03)00031-9 |
| [26] | Abd, E.M.M., et al. (2005) Age-Associated Changes in Pro-tein Oxidation and Proteasome Activities in Rat Brain: Modulation by Antioxidants. Biochemical and Biophysical Re-search Communications, 336, 386-391.
https://doi.org/10.1016/j.bbrc.2005.07.201 |
| [27] | Poon, H.F., et al. (2006) Proteomics Analyses of Specific Protein Oxidation and Protein Expression in Aged Rat Brain and Its Modulation by L-acetylcarnitine: Insights into the Mecha-nisms of Action of This Proposed Therapeutic Agent for CNS Disorders Associated with Oxidative Stress. Antioxidants & Redox Signaling, 8, 381-394.
https://doi.org/10.1089/ars.2006.8.381 |
| [28] | Lin, M.T. and Beal, M.F. (2006) Mitochondrial Dysfunction and Oxi-dative Stress in Neurodegenerative Diseases. Nature, 443, 787-795. https://doi.org/10.1038/nature05292 |
| [29] | 韩君, 等. 75岁及以上社区老年人身体衰弱与认知功能现状及相关性分析[J]. 复旦学报(医学版), 2021, 48(4): 494-502+544. |
| [30] | Ge, M., et al. (2020) Prevalence and Its Associated Factors of Physical Frailty and Cognitive Im-pairment: Findings from the West China Health and Aging Trend Study (WCHAT). The Journal of Nutrition, Health and Aging, 24, 525-533.
https://doi.org/10.1007/s12603-020-1363-y |
| [31] | 董晓慧, 等. 老年认知障碍风险简易预测模型[J]. 老年医学与保健, 2022, 28(1): 24-29. |
| [32] | 郑静, 崔焱. 养老机构衰弱老年人轻度认知障碍的现状及影响因素[J]. 实用老年医学, 2018, 32(10): 996-998. |
| [33] | 廖再波, 王龙, 邓学学. 老年2型糖尿病患者衰弱与认知功能现状及相关性分析[J]. 实用医院临床杂志, 2021, 18(4): 116-119. |
| [34] | Canevelli, M., Cesari, M. and van Kan, G.A. (2015) Frailty and Cognitive Decline: How do They Relate? Current Opinion in Clinical Nutrition & Metabolic Care, 18, 43-50. https://doi.org/10.1097/MCO.0000000000000133 |
| [35] | Boyle, P.A., et al. (2010) Physical Frailty Is Associated with Incident Mild Cognitive Impairment in Community-Based Older Persons. Journal of the American Geriatrics Soci-ety, 58, 248-255.
https://doi.org/10.1111/j.1532-5415.2009.02671.x |
| [36] | Jang, J.Y. and Kim, J. (2015) Association between Hand-grip Strength and Cognitive Impairment in Elderly Koreans: A Population-Based Cross-Sectional Study. The Journal of Physical Therapy Science, 27, 3911-3915.
https://doi.org/10.1589/jpts.27.3911 |
| [37] | Yassuda, M.S., et al. (2012) Frailty Criteria and Cognitive Performance Are Related: Data from the FIBRA Study in Ermelino Matarazzo, Sao Paulo, Brazil. The Journal of Nutrition, Health and Aging, 16, 55-61.
https://doi.org/10.1007/s12603-012-0003-6 |
| [38] | 郑静, 陈申, 崔焱. 机构老年人衰弱与轻度认知障碍的相关性研究[J]. 实用老年医学, 2019, 33(2): 206-208. |
| [39] | Auyeung, T.W., et al. (2011) Physical Frailty Predicts Future Cognitive Decline—A Four-Year Prospective Study in 2737 Cognitively Normal Older Adults. The Journal of Nutrition, Health and Aging, 15, 690-694.
https://doi.org/10.1007/s12603-011-0110-9 |
| [40] | Taekema, D.G., et al. (2012) Temporal Relationship between Handgrip Strength and Cognitive Performance in Oldest Old People. Age Ageing, 41, 506-512. https://doi.org/10.1093/ageing/afs013 |
| [41] | Atkinson, H.H., et al. (2010) The Relationship between Cognitive Func-tion and Physical Performance in Older Women: Results from the Women’s Health Initiative Memory Study. The Jour-nals of Gerontology, Series A: Biological Sciences and Medical Sciences, 65, 300-306. https://doi.org/10.1093/gerona/glp149 |
| [42] | 杨艳蓉, 等. 60岁以上住院患者衰弱现状及其与认知功能的相关性分析[J]. 中国全科医学, 2020, 23(17): 2132-2136+2141. |
| [43] | 杨佳佳, 等. 老年人握力与认知功能的关联性[J]. 中华老年医学杂志, 2022, 41(2): 206-210. |
| [44] | Stijntjes, M., et al. (2017) Temporal Relationship between Cognitive and Physical Performance in Middle-Aged to Oldest Old People. The Journals of Gerontology, Series A: Biological Sci-ences and Medical Sciences, 72, 662-668. |
| [45] | Verghese, J., et al. (2013) Motoric Cognitive Risk Syndrome and the Risk of Dementia. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 68, 412-418. https://doi.org/10.1093/gerona/gls191 |
| [46] | Shen, S., et al. (2020) Association between Motoric Cognitive Risk Syndrome and Frailty among Older Chinese Adults. BMC Geriatrics, 20, Article No. 110. https://doi.org/10.1186/s12877-020-01511-0 |
| [47] | Cano, C., et al. (2012) Frailty and Cognitive Impairment as Pre-dictors of Mortality in Older Mexican Americans. The Journal of Nutrition, Health and Aging, 16, 142-147. https://doi.org/10.1007/s12603-011-0104-7 |
| [48] | Jacobs, J.M., et al. (2011) Frailty, Cognitive Impairment and Mortality among the Oldest Old. The Journal of Nutrition, Health and Aging, 15, 678-682. https://doi.org/10.1007/s12603-011-0096-3 |
| [49] | Kusumastuti, S., et al. (2022) Do Changes in Frailty, Physical Functioning, and Cognitive Functioning Predict Mortality in Old Age? Results from the Longitudinal Aging Study Am-sterdam. BMC Geriatrics, 22, Article No. 193.
https://doi.org/10.1186/s12877-022-02876-0 |
| [50] | Ament, B., et al. (2014) Are Physically Frail Older Persons More at Risk of Adverse Outcomes If They Also Suffer from Cognitive, Social, and Psychological Frailty? European Journal of Ageing, 11, 213-219.
https://doi.org/10.1007/s10433-014-0308-x |
