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长链非编码RNA TINCR在肿瘤中的作用研究进展
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Abstract:
随着高通量测序技术的发展，一类转录本长度大于200 nt的RNA分子——长链非编码RNA (long non-coding RNA, lncRNA)，成为了肿瘤领域的研究热点。研究表明，lncRNA在诸多肿瘤的发生发展过程中均发挥着十分重要的作用。组织分化诱导非蛋白编码RNA (Terminal differentiation-induced non-coding RNA, TINCR)在表皮细胞分化过程中至关重要。近年来研究发现，TINCR在肝细胞癌、乳腺癌、肺癌、前列腺癌、膀胱癌等多种恶性肿瘤中表达异常，且能通过不同机制影响肿瘤进程。TINCR有望成为肿瘤早期诊断、治疗及预后的分子靶标。
With the development of high-throughput sequencing technology, lncRNA, whose transcripts are longer than 200 nt, has become the research hotspots in tumorigenesis. Research shows that lncRNA plays a key role in the occurrence and development of numerous tumors. Terminal differ-entiation-induced non-coding RNA (TINCR) was found to control human epidermal differentiation. Recently, TINCR has been found to have aberrant expression in multiple malignant tumors such as hepatocellular carcinoma, breast cancer, lung cancer, prostate cancer and bladder cancer, and be involved in tumorigenesis through different mechanism. TINCR are expected to be a new molecular target for early diagnosis, treatment and prognosis of malignant tumors.
| [1] | Sung, H., Ferlay, J., Siegel, R.L., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249.
https://doi.org/10.3322/caac.21660 |
| [2] | Blythe, A.J., Fox, A.H. and Bond, C.S. (2016) The Ins and Outs of lncRNA Structure: How, Why and What Comes Next? Biochimica et Biophysica Acta, 1859, 46-58. https://doi.org/10.1016/j.bbagrm.2015.08.009 |
| [3] | He, J., Tu, C. and Liu, Y. (2018) Role of lncRNAs in Aging and Age-Related Diseases. Aging Medicine, 1, 158-175.
https://doi.org/10.1002/agm2.12030 |
| [4] | Bartonicek, N., Maag, J.L. and Dinger, M.E. (2016) Long Noncoding RNAs in Cancer: Mechanisms of Action and Technological Advancements. Molecular Cancer, 15, Article No. 43. https://doi.org/10.1186/s12943-016-0530-6 |
| [5] | Gibb, E.A., Brown, C.J. and Lam, W.L. (2011) The Functional Role of Long Non-Coding RNA in Human Carcinomas. Molecular Cancer, 10, Article No. 38. https://doi.org/10.1186/1476-4598-10-38 |
| [6] | Xu, T.P., Wang, Y.F., Xiong, W.L., et al. (2017) E2F1 Induces TINCR Transcriptional Activity and Accelerates Gastric Cancer Progression via Activation of TINCR/STAU1/CDKN2B Signaling Axis. Cell Death & Disease, 8, e2837.
https://doi.org/10.1038/cddis.2017.205 |
| [7] | Chen, Z., Liu, H., Yang, H., et al. (2017) The Long Noncoding RNA, TINCR, Functions as a Competing Endogenous RNA to Regulate PDK1 Expression by Sponging miR-375 in Gastric Cancer. OncoTargets and Therapy, 10, 3353-3362. https://doi.org/10.2147/OTT.S137726 |
| [8] | Dong, H., Hu, J., Zou, K., et al. (2019) Activation of LncRNA TINCR by H3K27 Acetylation Promotes Trastuzumab Resistance and Epi-thelial-Mesenchymal Transition by Targeting MicroRNA-125b in Breast Cancer. Molecular Cancer, 18, Article No. 3. https://doi.org/10.1186/s12943-018-0931-9 |
| [9] | Dong, L., Ding, H., Li, Y., et al. (2018) LncRNA TINCR Is Associated with Clinical Progression and Serves as Tumor Suppressive Role in Prostate Cancer. Cancer Management and Research, 10, 2799-2807.
https://doi.org/10.2147/CMAR.S170526 |
| [10] | Hou, A., Zhang, Y., Zheng, Y., et al. (2019) LncRNA Terminal Differentiation-Induced ncRNA (TINCR) Sponges miR-302 to Upregulate Cyclin D1 in Cervical Squamous Cell Carci-noma (CSCC). Human Cell, 32, 515-521.
https://doi.org/10.1007/s13577-019-00268-y |
| [11] | Xu, G., Yang, H., Liu, M., et al. (2020) lncRNA TINCR Facili-ties Bladder Cancer Progression via Regulating miR7 and mTOR. Molecular Medicine Reports, 22, 4243-4253. https://doi.org/10.3892/mmr.2020.11530 |
| [12] | Ghafouri-Fard, S., Dashti, S., Taheri, M., et al. (2020) TINCR: An lncRNA with Dual Functions in the Carcinogenesis Process. Non-Coding RNA Research, 5, 109-115. https://doi.org/10.1016/j.ncrna.2020.06.003 |
| [13] | Sharma, U., Barwal, T.S., Malhotra, A., et al. (2020) Long Non-Coding RNA TINCR as Potential Biomarker and Therapeutic Target for Cancer. Life Sciences, 257, Article ID: 118035. https://doi.org/10.1016/j.lfs.2020.118035 |
| [14] | Kretz, M., Siprashvili, Z., Chu, C., et al. (2013) Control of Somatic Tissue Differentiation by the Long Non-Coding RNA TINCR. Nature, 493, 231-235. https://doi.org/10.1038/nature11661 |
| [15] | Iwakiri, J., Terai, G. and Hamada, M. (2017) Computational Prediction of lncRNA-mRNA Interactionsby Integrating Tissue Specificity in Human Transcriptome. Biology Direct, 12, Article No. 15.
https://doi.org/10.1186/s13062-017-0183-4 |
| [16] | Tian, F., Xu, J., Xue, F., et al. (2017) TINCR Expression Is As-sociated with Unfavorable Prognosis in Patients with Hepatocellular Carcinoma. Bioscience Reports, 37, BSR20170301. https://doi.org/10.1042/BSR20170301 |
| [17] | Liu, X., Ma, J., Xu, F., Li, L., et al. (2018) TINCR Suppresses Prolif-eration and Invasion through Regulating miR- 544a/FBXW7 Axis in Lung Cancer. Biomedicine & Pharmacotherapy, 99, 9-17.
https://doi.org/10.1016/j.biopha.2018.01.049 |
| [18] | Zhu, Z.J. and He, J.K. (2018) TINCR Facilitates Non-Small Cell Lung Cancer Progression through BRAF-Activated MAPK Pathway. Biochemical and Biophysical Research Commu-nications, 497, 971-977.
https://doi.org/10.1016/j.bbrc.2018.02.059 |
| [19] | Ali Syeda, Z., Langden, S.S.S., Munkhzul, C., et al. (2020) Regu-latory Mechanism of MicroRNA Expression in Cancer. International Journal of Molecular Sciences, 21, Article No. 1723. https://doi.org/10.3390/ijms21051723 |
| [20] | Hill, M. and Tran, N. (2021) miRNA Interplay: Mechanisms and Consequences in Cancer. Disease Models & Mechanisms, 14, dmm047662. https://doi.org/10.1242/dmm.047662 |
| [21] | Zhao, Z., Sun, W., Guo, Z., et al. (2020) Mechanisms of lncRNA/MicroRNA Interactions in Angiogenesis. Life Sciences, 254, Article ID: 116900. https://doi.org/10.1016/j.lfs.2019.116900 |
| [22] | Liu Y., Song J. W., Lin J. Y., et al. (2020) Roles of Mi-croRNA-122 in Cardiovascular Fibrosis and Related Diseases. Cardiovascular Toxicology, 20, 463-473. https://doi.org/10.1007/s12012-020-09603-4 |
| [23] | Wu, K.L., Tsai, Y.M., Lien, C.T., et al. (2019) The Roles of MicroRNA in Lung Cancer. International Journal of Molecular Sciences, 20, Article No. 1611. https://doi.org/10.3390/ijms20071611 |
| [24] | Kong, W., Liu, X., Yin, G., et al. (2020) Extracellular Vesicle Derived miR-544 Downregulates Expression of Tumor Suppressor Promyelocytic Leukemia Zinc Finger Resulting in Increased Peritoneal Metastasis in Gastric Cancer. Aging, 12, 24009-24022. https://doi.org/10.18632/aging.104082 |
| [25] | Fang, P., Xiang, L., Chen, W., et al. (2019) LncRNA GAS5 Enhanced the Killing Effect of NK Cell on Liver Cancer through Regulating miR-544/RUNX3. Innate Immunity, 25, 99-109. https://doi.org/10.1177/1753425919827632 |
| [26] | Yeh, C.H., Bellon, M. and Nicot, C. (2018) FBXW7: A Critical Tumor Suppressor of Human Cancers. Molecular Cancer, 17, Article No. 115. https://doi.org/10.1186/s12943-018-0857-2 |
| [27] | Guo, F., Zhu, X., Zhao, Q., et al. (2020) miR5893p Sponged by the lncRNA TINCR Inhibits the Proliferation, Migration and Invasion and Promotes the Apoptosis of Breast Cancer Cells by Suppressing the Akt Pathway via IGF1R. International Journal of Molecular Medicine, 46, 989-1002. https://doi.org/10.3892/ijmm.2020.4666 |
| [28] | Yu, H., Lee, H., Herrmann, A., et al. (2014) Revisiting STAT3 Sig-nalling in Cancer: New and Unexpected Biological Functions. Nature Reviews Cancer, 14, 736-746. https://doi.org/10.1038/nrc3818 |
| [29] | Tang, C., Feng, W., Bao, Y., et al. (2021) Long Non-Coding RNA TINCR Promotes Hepatocellular Carcinoma Proliferation and Invasion via STAT3 Signaling by Direct Interacting with T-Cell Protein Tyrosine Phosphatase (TCPTP). Bioengineered, 12, 2119-2131. https://doi.org/10.1080/21655979.2021.1930336 |
| [30] | Wang, Q., Liu, J., You, Z., et al. (2021) LncRNA TINCR Favors Tumorigenesis via STAT3-TINCR-EGFR-Feedback Loop by Recruiting DNMT1 and Acting as a Competing Endogenous RNA in Human Breast Cancer. Cell Death & Disease, 12, Article No. 83. https://doi.org/10.1038/s41419-020-03188-0 |
| [31] | Mei, J., Lin, W., Li, S., et al. (2022) Long Noncoding RNA TINCR Facilitates Hepatocellular Carcinoma Progression and Dampens Chemosensitivity to Oxaliplatin by Regulating the miR-195-3p/ST6GAL1/NF-kappaB Pathway. Journal of Experimental & Clinical Cancer Research, 41, Article No. 5. https://doi.org/10.1186/s13046-021-02197-x |
| [32] | Lu, S., Qian, J., Guo, M., et al. (2019) Insights into a Crucial Role of TRIP13 in Human Cancer. Computational and Structural Biotechnology Journal, 17, 854-861. https://doi.org/10.1016/j.csbj.2019.06.005 |
