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术前ALBI评分预测肝癌患者肝移植术后生存情况的价值
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Abstract:
目的：探讨术前ALBI评分预测肝癌患者肝移植术后生存情况的临床价值。方法：回顾性分析青岛大学附属医院自2017年1月至2019年12月的180例肝癌肝移植患者的临床资料。采用受试者工作曲线(ROC)评价ALBI分级、MELD评分、ALBI评分对肝癌患者肝移植生存情况的预测能力，根据最佳界值将患者分为高ALBI组和低ALBI组。Kaplan-Meier法绘制生存曲线。结果：ALBI评分判断肝癌肝移植患者术后生存情况的ROC曲线下面积是0.577，最佳界值是？2.24。根据最佳界值将患者分为ALBI ≤ ？2.24组和ALBI > ？2.24组，低ALBI组肝癌肝移植患者术后总体生存率较高ALBI组高，两组差异均有统计学意义(P < 0.05)。结论：术前ALBI评分对肝癌肝移植患者术后生存情况有一定的预测价值。
Objective: To investigate the clinical value of preoperative ALBI score in predicting the survival of patients with liver cancer after liver transplantation. Methods: We retrospectively analyzed the clinical data of 180 patients with liver transplantation for hepatocellular carcinoma from January 2017 to December 2019 in the Affiliated Hospital of Qingdao University. The receiver working curve (ROC) was used to evaluate the predictive ability of ALBI grade, MELD score and ALBI score on the survival of liver transplantation in patients with hepatocellular carcinoma, and the patients were divided into high ALBI group and low ALBI group according to the best cut-off value. Kaplan-Meier method is used to draw survival curve. Cox proportional regression model is used to analyze the risk factors of liver transplantation prognosis in patients with hepatocellular carcinoma. Results: The area under the ROC curve of ALBI score for judging the survival of patients with liver cancer af-ter liver transplantation was 0.577, and the optimal cutoff value was ？2.24. The patients were di-vided into ALBI ≤ ？2.24 group and ALBI > ？2.24 group according to the optimal cut-off value. The overall survival rate of patients with hepatocellular carcinoma after liver transplantation in low ALBI group is higher than that in high ALBI group, and the difference between the two groups is statistically significant (P < 0.05). Conclusion: Preoperative ALBI score has a certain predictive val-ue in predicting the survival of patients with hepatocellular carcinoma after liver transplantation.
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