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岩藻多糖对盆腔肿瘤放疗所致急性放射性肠炎的疗效研究
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Abstract:
目的：评估岩藻多糖治疗急性放射性肠炎的安全性及疗效，为急性放射性肠炎的治疗提供新方法。方法：选择于青岛大学附属医院放疗科行盆腔肿瘤放射治疗的患者120例(2018年6月至2019年10月)。随机平均分成两组，对照组(60例)患者给予对症治疗措施，实验组(60例)在对症治疗措施基础上加用岩藻多糖，比较两组的放射性肠炎发病率、功能状态评分及血清中炎性因子水平。结果：1) 实验组放射性肠炎发病率低于对照组(P < 0.05)；2) 实验组在症状评分上低于对照组，在功能状态评分上高于对照组(P < 0.05)；3) 比较两组放疗前后血清中炎性细胞因子表达水平，差异有统计学意义(P < 0.05)。结论：岩藻多糖治疗放射性肠炎疗效确切，有效改善患者生活质量，值得临床推广。
Objective: To evaluate the safety and efficacy of fucoidan in the treatment of acute radiation enteri-tis and to provide a new method for the treatment of acute radiation enteritis. Methods: A total of 120 patients (from June 2018 to October 2019) were enrolled in the Department of Radiotherapy of the Affiliated Hospital of Qingdao University and received radiotherapy for pelvic tumors. The pa-tients in the control group (60 cases) were given symptomatic treatment measures, and the pa-tients in the experimental group (60 cases) were added with fucoidan on the basis of symptomatic treatment measures. The incidence of radioactive enteritis, the score of functional status and the level of inflammatory factors in serum were compared between the two groups. Results: 1) The in-cidence of radioactive enteritis in the experimental group was lower than that in the control group (P< 0.05); 2) The symptom score of the experimental group was lower than that of the control group, and the functional status score of the experimental group was higher than that of the control group (P < 0.05); 3) The expression levels of inflammatory cytokines in serum of the two groups before and after radiotherapy were compared, and the difference was statistically significant (P < 0.05). Conclusion: The effect of fucoidan on radioactive enteritis is definite, and it can effectively improve the quality of life of patients, which is worthy of clinical promotion.
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