30%超分子水杨酸联合类人胶原蛋白生物修复敷料治疗面部脂溢性皮炎疗效观察
Clinical Observation of 30% Supramolecular Salicylic Acid Combined with Humanoid Col-lagen Bioremediation Dressing in the Treat-ment of Facial Seborrheic Dermatitis

目的：观察生物修复敷料(类人胶原蛋白)联合30%超分子水杨酸治疗面部脂溢性皮炎的有效率和安全性。方法：选取我院皮肤科门诊收治的60例面部脂溢性皮炎患者，采用随机数字表分法将所有患者分为对照组(n = 30)和治疗组(n = 30)，对照组予0.03%他克莫司软膏外涂患处，治疗组予0.03%他克莫司软膏外涂 + 30%超分子水杨酸 + 类人胶原蛋白生物修复敷料。治疗结束后1月随诊观察临床症状改善情况和不良反应发生情况。结果：治疗前后，组内患者红斑、脂溢、瘙痒三项观察指标的评分以及总积分差异均具有统计学意义(P < 0.01)，治疗前后皮损面积评分的差异无统计学意义(P > 0.05)；治疗前后，组内患者皮损面积这一项观察指标的评分以及总积分差异有统计学意义(P < 0.05)；治疗前，红斑、脂溢、瘙痒3个观察指标的评分差异无统计学意义(P > 0.05)；治疗后组间各观察指标评分情况比较，红斑、脂溢、瘙痒三项观察指标的评分下降程度有显著统计学意义(P < 0.01)，组间皮损面积评分差异无统计学意义(P > 0.05)。两组患者治疗期间及治疗后均未发生严重不良反应。结论：30%超分子水杨酸联合类人胶原蛋白生物修复敷料治疗面部脂溢性皮炎有效率较高，不良反应小，适合临床推广。
Objective: To observe the efficacy and safety of bioremediation dressing (human-like collagen) combined with 30% supramolecular salicylic acid in the treatment of facial seborrheic dermatitis. Methods: Selected 60 patients with facial seborrheic dermatitis admitted to the dermatology out-patient department of our hospital, and divided all patients into the control group (n = 30) and the treatment group (n = 30) by random number table, and the control group received 0.03% tacroli-mus ointment was applied externally to the affected area, and the treatment group was given 0.03% tacrolimus ointment + 30% supramolecular salicylic acid + human-like collagen bioremediation dressing. One month after the treatment, the patients were followed up to observe the improve-ment of clinical symptoms and the occurrence of adverse reactions. Results: There were statistically significant differences in the scores of erythema, seborrhea and pruritus and total scores before and after treatment in the patients in the group (P < 0.01), but there was no significant difference in skin lesion area scores before and after treatment (P > 0.05); there was a statistically significant difference in the score of the skin lesion area and the total score of the patients in the group before and after treatment (P < 0.05). There was no statistically significant difference between the two groups (P > 0.05); comparing the scores of each observation index between the groups after treat-ment, the scores of the three observation indexes of erythema, seborrhea and pruritus decreased with statistical significance (P < 0.01). There was no significant difference in the score of mesothelial lesion area (P > 0.05). There were no serious adverse reactions in the two groups during and after treatment. Conclusion: 30% supramolecular salicylic acid combined with human-like collagen bio-remediation dressing has a higher effective rate and less adverse reactions in the treatment of facial seborrheic dermatitis, which is suitable