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慢性阻塞性肺疾病、骨质疏松与肌少症的相关性
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Abstract:
慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)、骨质疏松和肌少症均是老年患者的常见病和多发病,关于COPD和骨质疏松与肌少症的相关发病机制目前仍不明确。据以往的相关研究,COPD和骨质疏松较一般患者更易于发生肌少症。对于COPD合并骨质疏松是否会加深这种影响,目前尚无准确定论。本文将对目前国内外现有的成果进行综述,验证是否存在这种相关性,并尽可能的降低它们之间相互的发生率,改善患者预后,提高患者的生活质量。
Chronic obstructive pulmonary disease (COPD), osteoporosis and sarcopenia are common and prev-alent diseases in middle-aged and elderly patients. The mechanism of COPD, osteoporosis and sar-copenia is still unclear. According to previous studies, COPD and osteoporosis are more prone to sarcopenia than general patients. Whether COPD combined with osteoporosis will deepen this effect has not been accurately determined. This article will review the existing results at home and abroad, verify whether there is such a correlation, and try to reduce the incidence of mutual be-tween them, improve the prognosis of patients, improve the quality of life of patients.
[1] | Wouters, E.F., Creutzberg, E.C. and Schols, A.M. (2002) Systemic Effects in COPD. Chest, 121, 127S-130S.
https://doi.org/10.1378/chest.121.5_suppl.127S |
[2] | Chen, Y.W., Ramsook, A.H., Coxson, H.O., Bon, J. and Reid, W.D. (2019) Prevalence and Risk Factors for Osteoporosis in Individuals with COPD: A Systematic Review and Meta-Analysis. Chest, 156, 1092-1110.
https://doi.org/10.1016/j.chest.2019.06.036 |
[3] | Schnell, K., Weiss, C.O., Lee, T., et al. (2012) The Prevalence of Clinically-Relevant Comorbid Conditions in Patients with Physician-Diagnosed COPD: A Cross-Sectional Study Using Data from NHANES 1999-2008. BMC Pulmonary Medicine, 12, Article No. 26. https://doi.org/10.1186/1471-2466-12-26 |
[4] | Limpawattana, P., Inthasuwan, P., Putraveephong, S., Boonsawat, W., Theerakulpisut, D. and Sawanyawisuth, K. (2018) Sarcopenia in Chronic Obstructive Pulmonary Disease: A Study of Prevalence and Associated Factors in the Southeast Asian Population. Chronic Respiratory Disease, 15, 250-257. https://doi.org/10.1177/1479972317743759 |
[5] | Byun, M.K., Cho, E.N., Chang, J., Ahn, C.M. and Kim, H.J. (2017) Sarcopenia Correlates with Systemic Inflammation in COPD. International Journal of Chronic Obstructive Pul-monary Disease, 12, 669-675.
https://doi.org/10.2147/COPD.S130790 |
[6] | Xia, Z., Cholewa, J., Zhao, Y., et al. (2017) Targeting Inflammation and Downstream Protein Metabolism in Sarcopenia: A Brief Up-Dated Description of Concurrent Exercise and Leu-cine-Based Multimodal Intervention. Frontiers in Physiology, 8, Article No. 434. https://doi.org/10.3389/fphys.2017.00434 |
[7] | Ciciliot, S., Rossi, A.C., Dyar, K.A., Blaauw, B. and Schiaffino, S. (2013) Muscle Type and Fiber Type Specificity in Muscle Wasting. The International Journal of Biochemistry & Cell Biology, 45, 2191-2199.
https://doi.org/10.1016/j.biocel.2013.05.016 |
[8] | Correa-de-Araujo, R., Harris-Love, M.O., Miljkovic, I., Fragala, M.S., Anthony, B.W. and Manini, T.M. (2017) The Need for Standardized Assessment of Muscle Quality in Skeletal Muscle Function Deficit and Other Aging-Related Muscle Dysfunctions: A Symposium Report. Frontiers in Physiology, 8, Article No. 87.
https://doi.org/10.3389/fphys.2017.00087 |
[9] | Maltais, F., Decramer, M., Casaburi, R., et al. (2014) An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine, 189, e15-e62. https://doi.org/10.1164/rccm.201402-0373ST |
[10] | Koo, H.K., Park, J.H., Park, H.K., Jung, H. and Lee, S.S. (2014) Conflicting Role of Sarcopenia and Obesity in Male Patients with Chronic Obstructive Pulmonary Disease: Ko-rean National Health and Nutrition Examination Survey. PLoS ONE, 9, e110448. https://doi.org/10.1371/journal.pone.0110448 |
[11] | Jones, S.E., Maddocks, M., Kon, S.S., et al. (2015) Sarcopenia in COPD: Prevalence, Clinical Correlates and Response to Pulmonary Rehabilitation. Thorax, 70, 213-218. https://doi.org/10.1136/thoraxjnl-2014-206440 |
[12] | Tagliaferri, C., Wittrant, Y., Davicco, M.J., Walrand, S. and Coxam, V. (2015) Muscle and Bone, Two Interconnected Tissues. Ageing Research Reviews, 21, 55-70. https://doi.org/10.1016/j.arr.2015.03.002 |
[13] | 商海滨, 廉由之, 郭海玲, 等. 基于生物信息学探讨骨质疏松症与肌少症的关系[J]. 中国骨质疏松杂志, 2021, 27(10): 1458-1463. |
[14] | 中国健康促进基金会骨质疏松防治中国白皮书编委会. 骨质疏松症中国白皮书[J]. 中华健康管理学杂志, 2009, 3(3): 148-154. |
[15] | Clarke, B.L. and Kho-sla, S. (2010) Physiology of Bone Loss. Radiologic Clinics of North America, 48, 483-495.
https://doi.org/10.1016/j.rcl.2010.02.014 |
[16] | Khosla, S. (2010) Update in Male Osteoporosis. The Journal of Clinical Endocrinology & Metabolism, 95, 3-10.
https://doi.org/10.1210/jc.2009-1740 |
[17] | Orwoll, E., Lambert, L.C., Marshall, L.M., et al. (2006) Testosterone and Estradiol among Older Men. The Journal of Clinical Endocrinology & Metabolism, 91, 1336-1344. https://doi.org/10.1210/jc.2005-1830 |
[18] | Kirchengast, S. and Huber, J. (2009) Gender and Age Differences in Lean Soft Tissue Mass and Sarcopenia among Healthy Elderly. Anthropologischer Anzeiger, 67, 139-151. https://doi.org/10.1127/0003-5548/2009/0018 |
[19] | Lauretani, F., Russo, C.R., Bandinelli, S., et al. (2003) Age-Associated Changes in Skeletal Muscles and Their Effect on Mobility: An Operational Diagnosis of Sarcopenia. Journal of Applied Physiology, 95, 1851-1860.
https://doi.org/10.1152/japplphysiol.00246.2003 |
[20] | Ferrucci, L., Baroni, M., Ranchelli, A., et al. (2014) Interac-tion between Bone and Muscle in Older Persons with Mobility Limitations. Current Pharmaceutical Design, 20, 3178-3197. https://doi.org/10.2174/13816128113196660690 |
[21] | Qiu, S., Rao, D.S., Palnitkar, S. and Parfitt, A.M. (2002) Relationships between Osteocyte Density and Bone Formation Rate in Human Cancellous Bone. Bone, 31, 709-711. https://doi.org/10.1016/S8756-3282(02)00907-9 |
[22] | Gallagher, J.C., Riggs, B.L. and DeLuca, H.F. (1980) Effect of Estrogen on Calcium Absorption and Serum Vitamin D Metabolites in Postmenopausal Osteoporosis. The Journal of Clinical Endocrinology & Metabolism, 51, 1359-1364.
https://doi.org/10.1210/jcem-51-6-1359 |
[23] | McKane, W.R., Khosla, S., Burritt, M.F., et al. (1995) Mechanism of Renal Calcium Conservation with Estrogen Replacement Therapy in Women in Early Postmenopause—A Clinical Re-search Center Study. The Journal of Clinical Endocrinology & Metabolism, 80, 3458-3464. https://doi.org/10.1210/jc.80.12.3458 |
[24] | Kaptoge, S., Dalzell, N., Jakes, R.W., et al. (2003) Hip Section Modu-lus, a Measure of Bending Resistance, Is More Strongly Related to Reported Physical Activity than BMD. Osteoporosis International, 14, 941-949.
https://doi.org/10.1007/s00198-003-1484-2 |
[25] | Kortebein, P., Ferrando, A., Lombeida, J., Wolfe, R. and Evans, W.J. (2007) Effect of 10 Days of Bed Rest on Skeletal Muscle in Healthy Older Adults. Journal of the American Medical Association, 297, 1772-1774.
https://doi.org/10.1001/jama.297.16.1772-b |
[26] | Steffl, M., Bohannon, R.W., Sontakova, L., Tufano, J.J., Shiells, K. and Holmerova, I. (2017) Relationship between Sarcopenia and Physical Activity in Older People: A Systematic Re-view and Meta-Analysis. Clinical Interventions in Aging, 12, 835-845. https://doi.org/10.2147/CIA.S132940 |
[27] | Denison, H.J., Cooper, C., Sayer, A.A. and Robinson, S.M. (2015) Prevention and Optimal Management of Sarcopenia: A Review of Combined Exercise and Nutrition Interventions to Im-prove Muscle Outcomes in Older People. Clinical Interventions in Aging, 10, 859-869. https://doi.org/10.2147/CIA.S55842 |
[28] | Blomstrand, E., Eliasson, J., Karlsson, H.K. and K?hnke, R. (2006) Branched-Chain Amino Acids Activate Key Enzymes in Protein Synthesis after Physical Exercise. The Journal of Nutri-tion, 136, 269S-273S.
https://doi.org/10.1093/jn/136.1.269S |
[29] | Graat-Verboom, L., Wouters, E.F., Smeenk, F.W., van den Borne, B.E., Lunde, R. and Spruit, M.A. (2009) Current Status of Research on Osteoporosis in COPD: A Systematic Review. Euro-pean Respiratory Journal, 34, 209-218.
https://doi.org/10.1183/09031936.50130408 |
[30] | Chua, J.R. and Tee, M.L. (2020) Association of Sarcopenia with Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease. Osteoporosis and Sarcopenia, 6, 129-132. https://doi.org/10.1016/j.afos.2020.07.004 |