中毒性表皮坏死松解症(toxic
epidermal necrolysis, TEN)是一种罕见的严重威胁生命的疾病，多由药物诱发，或由疱疹病毒、支原体等病原体感染所致。TEN表现为表皮剥蚀和粘膜病变，类似烧伤表现，诊断主要依赖临床体征和组织学分析，并且治疗需要早期停止致病药物和支持性治疗。本文报道1例因发热抽搐用药治疗后所致重症TEN，经过抗炎对症治疗、呼吸、循环支持治疗、使用聚维酮碘、生长因子、银离子敷料治愈大面积皮肤损伤，取得满意效果。
Toxic
epidermal necrolysis (TEN) is a rare, severe, life-threatening disease that is
mostly drug-induced or caused by infection with pathogens such as herpes
virus and mycoplasma. TEN presents with epidermal ablation and mucosal lesions,
similar to burn manifestations, and the diagnosis is predominantly clinical
signs and histological analysis, and treatment requires early cessation of
causative drugs and supportive therapy. This article reports one case of severe
illness caused by febrile convulsions after drug treatment, after
anti-inflammatory symptomatic therapy, respiratory, circulatory support
therapy, the use of povidone iodine, growth factors, silver ion dressing to
cure a large area of skin damage, achieved satisfactory results.
