This study provided new data in the area of cross-reactivity for Pacific white shrimp (Litopenaeus vannamei). Although the cross-reactivity between the most prominent allergenic proteins of shrimp and other crustaceans has been extensively studied, few data are showing the frequency of arthropod-shrimp Litopenaeus vannamei cosensitization in an in silico analysis. A comparative analysis of “typical and non-typical” shrimp L. vannamei allergens with other species was achieved, revealing new allergens and previously characterized shrimp allergens, which validated the comprehensive identification approach used in this study. Importantly, up to 192, amino acid sequences were identified that had matches to shrimp L. vannamei allergens that matched allergenic proteins in mites, insects, fish, bacteria, mammals, birds, and plants.
References
[1]
Faber, M.A., Van Gasse, A.L., Decuyper, I.I., Sabato, V., Hagendorens, M.M., Mertens, C., Bridts, C.H., De Clerck, L.S., and Ebo, D.G. (2018) Cross-Reactive Aeroallergens: Which Need to Cross Our Mind in Food Allergy Diagnosis? The Journal of Allergy and Clinical Immunology. In Practice, 6, 1813-1823.
https://doi.org/10.1016/j.jaip.2018.08.010
[2]
Wai, C., Leung, N., Chu, K.H., Leung, P., Leung, A., Wong, G., and Leung, T.F. (2020) Overcoming Shellfish Allergy: How Far Have We Come? International Journal of Molecular Sciences, 21, Article No. 2234.
https://doi.org/10.3390/ijms21062234
[3]
El-Qutob, D. (2017) Shrimp Allergy: Beyond Avoidance Diet. European Annals of Allergy and Clinical Immunology, 49, 252-256.
https://doi.org/10.23822/EurAnnACI.1764-1489.16
[4]
Lopata, A.L., Kleine-Tebbe, J., and Kamath, S.D. (2016) Allergens and Molecular Diagnostics of Shellfish Allergy: Part 22 of the Series Molecular Allergology. Allergo Journal International, 25, 210-218. https://doi.org/10.1007/s40629-016-0124-2
[5]
De Marchi, L., Wangorsch, A., and Zoccatelli, G. (2021) Allergens from Edible Insects: Cross-Reactivity and Effects of Processing. Current Allergy and Asthma Reports, 21, Article No. 35. https://doi.org/10.1007/s11882-021-01012-z
[6]
Olivia, L., Francis, M., Kathleen Y. Wang, J., Edwin H., and Timothy P. (2020) Common Food Allergens and Cross-Reactivity. Journal of Food Allergy, 2, 17-21.
https://doi.org/10.2500/jfa.2020.2.200020
[7]
Davis, C.M., Gupta, R.S., Aktas, O.N., Diaz, V., Kamath, S.D., and Lopata, A.L. (2020) Clinical Management of Seafood Allergy. The Journal of Allergy and Clinical Immunology. In Practice, 8, 37-44. https://doi.org/10.1016/j.jaip.2019.10.019
[8]
Shen, C.Y., Tsai, J.J., and Liao, E.C. (2019) Cross-Reactivity of sIgE to Mite and Shrimp-Induced Allergies in Different Age Groups and Clinical Profiles of Shrimp sIgE in Vegetarians. Scientific Reports, 9, Article No. 12548.
https://doi.org/10.1038/s41598-019-49068-2
[9]
Hata, T., Furusawa-Horie, T., Arai, Y., Takahashi, T., Seishima, M., and Ichihara, K. (2020) Studies of Royal Jelly and Associated Cross-Reactive Allergens in Atopic Dermatitis Patients. PLoS ONE, 15, e0233707.
https://doi.org/10.1371/journal.pone.0233707
[10]
Ruethers, T., Taki, A.C., Johnston, E.B., Nugraha, R., Le, T., Kalic, T., McLean, T.R., Kamath, S.D., and Lopata, A.L. (2018) Seafood Allergy: A Comprehensive Review of Fish and Shellfish Allergens. Molecular Immunology, 100, 28-57.
https://doi.org/10.1016/j.molimm.2018.04.008
[11]
Leung, A., Leung, N., Wai, C., Leung, T.F., and Wong, G. (2019) Allergen Immunotherapy for Food Allergy from the Asian Perspective: Key Challenges and Opportunities. Expert review of Clinical Immunology, 15, 153-164.
https://doi.org/10.1080/1744666X.2019.1554432
[12]
Emiliani, Y., Sánchez, A., Munera, M., Sánchez, J., and Aparicio, D. (2021) In Silico Analysis of Cross-Reactivity among Phospholipases from Hymenoptera Species. F1000Research, 10, 2-12. https://doi.org/10.12688/f1000research.27089.2
[13]
Abramovitch, J.B., Kamath, S., Varese, N., Zubrinich, C., Lopata, A.L., O’Hehir, R.E., and Rolland, J.M. (2013) IgE Reactivity of Blue Swimmer Crab (Portunus pelagicus) Tropomyosin, Por p 1, and Other Allergens; Cross-Reactivity with Black Tiger Prawn and Effects of Heating. PLoS ONE, 8, e67487.
https://doi.org/10.1371/journal.pone.0067487
[14]
Wong, L., Tham, E.H., and Lee, B.W. (2019) An Update on Shellfish Allergy. Current Opinion in Allergy and Clinical Immunology, 19, 236-242.
https://doi.org/10.1097/ACI.0000000000000532
[15]
Raulf, M. (2018) Allergen Component Analysis as a Tool in Diagnosing and Managing Occupational Allergy. Molecular Immunology, 100, 21-27.
https://doi.org/10.1016/j.molimm.2018.03.013
[16]
Nguyen, D.I., Sindher, S.B., Chinthrajah, R.S., Nadeau, K. and Davis, C.M. (2022) Shrimp-Allergic Patients in a Multi-Food Oral Immunotherapy Trial. Pediatric Allergy and Immunology: Official Publication of the European Society of Pediatric Allergy and Immunology, 33, e13679. https://doi.org/10.1111/pai.13679
[17]
Kamath, S.D., Johnston, E.B., Iyer, S., Schaeffer, P.M., Koplin, J., Allen, K., and Lopata, A.L. (2017) IgE Reactivity to Shrimp Allergens in Infants and Their Cross-Reactivity to House Dust Mite. Pediatric Allergy and Immunology, 28, 703-707.
https://doi.org/10.1111/pai.12764
[18]
López-Matas, M.A., de Larramendi, C.H., Moya, R., Sánchez-Guerrero, I., Ferrer, A., Huertas, A.J., Flores, I., Navarro, L.A., García-Abujeta, J.L., Vicario, S., Andreu, C., Pena, M., and Carnés, J. (2016) In Vivo Diagnosis with Purified Tropomyosin in Mite and Shellfish Allergic Patients. Annals of Allergy, Asthma & Immunology, 116, 538-543. https://doi.org/10.1016/j.anai.2016.03.034
[19]
Celakovská, J., Josef, B., Vaneckova, J., Krcmova, I., Komorousová, M., Cetkovská, P., Vankova, R., and Krejsek, J. (2020) Food Hypersensitivity Reactions to Seafish in Atopic Dermatitis Patients Older than 14 Years of Age—The Evaluation of Association with Other Allergic Diseases and Parameters. Indian Journal of Dermatology, 65, 97-104. https://doi.org/10.4103/ijd.IJD_403_18
Pali-Scholl, I., Meinlschmidt, P., Larenas-Linnemann, D., Purschke, B., Hofstetter, G., Rodríguez-Monroy, F.A., Einhorn, L., Mothes-Luksch, N., Jensen-Jarolim, E., and Jager, H. (2019) Edible Insects: Cross-Recognition of IgE from Crustacean- and House Dust Mite Allergic Patients, and Reduction of Allergenicity by Food Processing. The World Allergy Organization Journal, 12, Article ID: 100006.
https://doi.org/10.1016/j.waojou.2018.10.001
[22]
Faber, M.A., Pascal, M., El Kharbouchi, O., Sabato, V., Hagendorens, M.M., Decuyper, I.I., Bridts, C.H., and Ebo, D.G. (2017) Shellfish Allergens: Tropomyosin and beyond. Allergy, 72, 842-848. https://doi.org/10.1111/all.13115
[23]
Carrera, M., Pazos, M., and Gasset, M. (2020) Proteomics-Based Methodologies for the Detection and Quantification of Seafood Allergens. Foods, 9, Article No. 1134.
https://doi.org/10.3390/foods9081134
[24]
Asero, R., Pravettoni, V., Scala, E. and Villalta, D. (2020) House Dust Mite-Shrimp Allergen Interrelationships. Current Allergy and Asthma Reports, 20, Article No. 9.
https://doi.org/10.1007/s11882-020-0902-2
[25]
Hernández-Moreno, K.E., Munoz, M., Calvo, V., Diez-Zuluaga, L.S., and Sánchez, J. (2019) Relación entre la sensibilización a camarón y ácaros. Exploración de la reactividad cruzada por tropomiosina [Relationship between the Sensitization to Shrimp and Mites. Exploration of Cross-Reactivity Due Tropomyosin]. Revista alergia Mexico, 66, 205-216.
[26]
Fan, S., Ma, J., Li, C., Wang, Y., Zeng, W., Li, Q., Zhou, J., Wang, L., Wang, Y. and Zhang, Y. (2022) Determination of Tropomyosin in Shrimp and Crab by Liquid Chromatography-Tandem Mass Spectrometry Based on Immunoaffinity Purification. Frontiers in Nutrition, 9, Article ID: 848294.
https://doi.org/10.3389/fnut.2022.848294
[27]
Karnaneedi, S., Huerlimann, R., Johnston, E.B., Nugraha, R., Ruethers, T., Taki, A.C., Kamath, S.D., Wade, N.M., Jerry, D.R., and Lopata, A.L. (2020) Novel Allergen Discovery through Comprehensive De novo Transcriptomic Analyses of Five Shrimp Species. International Journal of Molecular Sciences, 22, Article No. 32.
https://doi.org/10.3390/ijms22010032
[28]
Gámez, C., Zafra, M., Boquete, M., Sanz, V., Mazzeo, C., Ibánez, M.D., Sánchez-García, S., Sastre, J., and del Pozo, V. (2014) New Shrimp IgE-Binding Proteins Involved in Mite-Seafood Cross-Reactivity. Molecular Nutrition & Food Research, 58, 1915-1925. https://doi.org/10.1002/mnfr.201400122
[29]
Pomés, A., Davies, J.M., Gadermaier, G., Hilger, C., Holzhauser, T., Lidholm, J., Lopata, A.L., Mueller, G.A., Nandy, A., Radauer, C., Chan, S. K., Jappe, U., Kleine-Tebbe, J., Thomas, W. R., Chapman, M. D., van Hage, M., van Ree, R., Vieths, S., Raulf, M., Goodman, R.E., et al. (2018) WHO/IUIS Allergen Nomenclature: Providing a Common Language. Molecular Immunology, 100, 3-13.
https://doi.org/10.1016/j.molimm.2018.03.003
[30]
Goodman, R.E., Ebisawa, M., Ferreira, F., Sampson, H.A., van Ree, R., Vieths, S., Baumert, J.L., Bohle, B., Lalithambika, S., Wise, J., and Taylor, S.L. (2016) AllergenOnline: A Peer-Reviewed, Curated Allergen Database to Assess Novel Food Proteins for Potential Cross-Reactivity. Molecular Nutrition & Food Research, 60, 1183-1198. https://doi.org/10.1002/mnfr.201500769
[31]
Nugraha, R., Kamath, S.D., Johnston, E., Zenger, K.R., Rolland, J.M., O’Hehir, R.E., and Lopata, A.L. (2018) Rapid and Comprehensive Discovery of Unreported Shellfish Allergens Using Large-Scale Transcriptomic and Proteomic Resources. The Journal of Allergy and Clinical Immunology, 141, 1501-1504.E8.
https://doi.org/10.1016/j.jaci.2017.11.028
[32]
Aalberse R.C. (2000) Structural Biology of Allergens. The Journal of Allergy and Clinical Immunology, 106, 228-238. https://doi.org/10.1067/mai.2000.108434
[33]
Abdel Rahman, A.M., Kamath, S.D., Lopata, A.L., Robinson, J.J., and Helleur, R.J. (2011) Biomolecular Characterization of Allergenic Proteins in Snow Crab (Chionoecetes opilio) and De novo Sequencing of the Second Allergen Arginine Kinase Using Tandem Mass Spectrometry. Journal of Proteomics, 74, 231-241.
https://doi.org/10.1016/j.jprot.2010.10.010
[34]
Liu, Z., Xia, L., Wu, Y., Xia, Q., Chen, J., and Roux, K.H. (2009) Identification and Characterization of an Arginine Kinase as a Major Allergen from Silkworm (Bombyx mori) Larvae. International Archives of Allergy and Immunology, 150, 8-14.
https://doi.org/10.1159/000210375
[35]
Bobolea, I., Barranco, P., Pastor-Vargas, C., Iraola, V., Vivanco, F., and Quirce, S. (2011) Arginine Kinase from the Cellar Spider (Holocnemus pluchei): A New Asthma-Causing Allergen. International Archives of Allergy and Immunology, 155, 180-186. https://doi.org/10.1159/000319822
[36]
Gelis, S., Rueda, M., Valero, A., Fernández, E.A., Moran, M., and Fernández-Caldas, E. (2020) Shellfish Allergy: Unmet Needs in Diagnosis and Treatment. Journal of Investigational Allergology & Clinical Immunology, 30, 409-420.
https://doi.org/10.18176/jiaci.0565
[37]
Zhang, B., Yao, H., Qi, H., and Zhang, X.L. (2020) Trehalose and Alginate Oligosaccharides Increase the Stability of Muscle Proteins in Frozen Shrimp (Litopenaeus vannamei). Food & Function, 11, 1270-1278. https://doi.org/10.1039/C9FO02016K
[38]
Nugraha, R., Kamath, S.D., Johnston, E., Karnaneedi, S., Ruethers, T., and Lopata, A.L. (2019) Conservation Analysis of B-Cell Allergen Epitopes to Predict Clinical Cross-Reactivity Between Shellfish and Inhalant Invertebrate Allergens. Frontiers in Immunology, 10, Article No. 2676. https://doi.org/10.3389/fimmu.2019.02676
[39]
Zhang, Y.X., Chen, H.L., Maleki, S.J., Cao, M.J., Zhang, L.J., Su, W.J., and Liu, G.M. (2015) Purification, Characterization, and Analysis of the Allergenic Properties of Myosin Light Chain in Procambarus clarkii. Journal of Agricultural and Food Chemistry, 63, 6271-6282. https://doi.org/10.1021/acs.jafc.5b01318
[40]
Johnston, E.B., Kamath, S.D., Iyer, S.P., Pratap, K., Karnaneedi, S., Taki, A.C., Nugraha, R., Schaeffer, P.M., Rolland, J.M., O’Hehir, R.E., and Lopata, A.L. (2019) Defining Specific Allergens for Improved Component-Resolved Diagnosis of Shrimp Allergy in Adults. Molecular Immunology, 112, 330-337.
https://doi.org/10.1016/j.molimm.2019.05.006
[41]
Ayuso, R., Grishina, G., Ibánez, M.D., Blanco, C., Carrillo, T., Bencharitiwong, R., Sánchez, S., Nowak-Wegrzyn, A., and Sampson, H.A. (2009) Sarcoplasmic Calcium-Binding Protein Is an EF-Hand-Type Protein Identified as a New Shrimp Allergen. The Journal of Allergy and Clinical Immunology, 124, 114-120.
https://doi.org/10.1016/j.jaci.2009.04.016
[42]
Akimoto, S., Yokooji, T., Ogino, R., Chinuki, Y., Taogoshi, T., Adachi, A., Morita, E. and Matsuo, H. (2021) Identification of Allergens for Food-Dependent Exercise-Induced Anaphylaxis to Shrimp. Scientific Reports, 11, 5400.
https://doi.org/10.1038/s41598-021-84752-2
[43]
Radauer, C., Bublin, M., Wagner, S., Mari, A., and Breiteneder, H. (2008) Allergens Are Distributed into a Few Protein Families and Possess a Restricted Number of Biochemical Functions. The Journal of Allergy and Clinical Immunology, 121, 847-852.E7. https://doi.org/10.1016/j.jaci.2008.01.025
[44]
Wang, H., Lin, J., Liu, X., Liang, Z., Yang, P., Ran, P., and Liu, Z. (2016) Identification of α-Tubulin, Der f 33, as a Novel Allergen from Dermatophagoides farinae. Immunobiology, 221, 911-917. https://doi.org/10.1016/j.imbio.2016.03.004
[45]
Celakovská J., Bukac J., Vaňková R., Krejsek J., Andrys C. and Krcmova I. (2020) Food Allergy to Shrimps and Fish in Patients Suffering from Atopic Dermatitis, the Results of ISAC Multiplex Examination. Food and Agricultural Immunology, 31, 1061-1078. https://doi.org/10.1080/09540105.2020.1826911
