|
|
面向射频组织焊接的可降解电极结构设计与实验研究
|
Abstract:
目的：研究可降解镁合金作为射频能量组织焊接电极时对肠道吻合口热损伤与生物力学强度的影响。方法：对传统铜电极和新型镁合金电极在射频焊接过程中肠道吻合口的温度变化和组织热损伤进行仿真分析。同时，通过离体实验对仿真结果进行验证，探索在两组电极边缘处和距边缘3 mm处组织温度的变化规律，并对镁合金电极焊接的组织吻合口进行生物力学强度测试和组织微观结构观察。结果：与铜电极相比，镁合金电极能够有效降低焊接区域的平均温度(90℃ vs 75℃)和侧向热损伤距离(3.3 mm vs 2.7 mm)，提高吻合口的生物力学强度(爆破压：126.01 ± 16.02 mmHg vs 167.01 ± 30.41 mmHg，撕脱力：18.87 ± 3.15 N vs 22.14 ± 1.59 N)。结论：本文验证了镁合金作为射频组织焊接电极的可行性与有效性，所取得的研究成果，为实现人体管腔组织的无缝连接提供了新的思路。
Objective: The effect of degradable magnesium alloy as radiofrequency energy tissue welding electrode on thermal damage and biomechanical properties of intestinal anastomosis was studied. Methods: The temperature change and tissue thermal damage of intestinal anastomosis during radiofrequency welding of traditional copper electrode and new magnesium alloy electrode were simulated and analyzed. Meanwhile, the simulation results were verified by in vitro experiments, and the two groups of electrodes were explored at the edge and 3 mm from the edge. The biomechanical properties and microstructure of the anastomosis of magnesium alloy electrode welding were tested. Results: Compared with copper electrode, magnesium alloy electrode can effectively reduce the average temperature of welding zone (90？C vs 75？C) and lateral thermal damage distance (3.3 mm vs 2.7 mm), and improve the biomechanical properties of anastomosis (burst pressure: 126.01 ± 16.02 mmHg vs 167.01 ± 30.41 mmHg, avulsion force: 18.87 ± 3.15 N vs 22.14 ± 1.59 N). Conclusion: In this study, the feasibility and effectiveness of magnesium alloy as radiofrequency tissue welding electrode were verified, and the research results provided a new idea for realizing the seamless connection of human lumen tissue.
| [1] | 王悠清, Sung, H., Ferlay, J., 等. 2020年全球癌症统计报告[J]. 中华预防医学杂志, 2021, 55(3): 398. |
| [2] | 贾振杰. 胃肠吻合技术进展研究[J]. 中国医疗器械信息, 2019, 25(5): 60-61. |
| [3] | 陈力, 宋成利, 于锡潼, 毛琳. 射频能量肠道焊接技术的研究进展[J]. 北京生物医学工程, 2020, 39(1): 92-95, 107. |
| [4] | 胡钟欣, 宗乃馨, 黄婷, 宋成利, 毛琳. 基于能量的生物组织吻合技术研究进展[J]. 生物医学工程学进展, 2021, 42(1): 25-29. |
| [5] | Tu, L.Y., Zhou, Y., Song, C.L., Li, Y., Chen, L. and Xue, Y. (2019) Preliminary Study of a Control Algorithm for Radio-Frequency-Induced Intestinal Tissue Fusion. International Journal of Hyperthermia, 36, 1297-1306.
https://doi.org/10.1080/02656736.2019.1702723 |
| [6] | 张宏辉, 冯海全, 李治国, 韩青松. 镁合金冠脉支架支撑性能分析及其优化[J]. 医用生物力学, 2019, 34(1): 14-20. |
| [7] | 袁广银, 章晓波, 牛佳林, 陶海荣, 陈道运, 何耀华, 等. 新型可降解生物医用镁合金JDBM的研究进展[J]. 中国有色金属学报, 2011, 21(10): 2476-2488. |
| [8] | Pan, H.C., Pan, F.S., Wang, X., Peng, J., Gou, J., She, J., et al. (2013) Correlation on the Electrical and Thermal Conductivity for Binary Mg-Al and Mg-Zn Alloys. International Journal of Thermophysics, 34, 1336-1346.
https://doi.org/10.1007/s10765-013-1490-3 |
| [9] | Kabiri, A. and Talaee, M.R. (2021) Analysis of Hyperbolic Pennes Bioheat Equation in Perfused Homogeneous Biological Tissue Subject to the Instantaneous Moving Heat Source. SN Applied Sciences, 3, Article No. 398.
https://doi.org/10.1007/s42452-021-04379-w |
| [10] | Xie, Z.W. (2019) Bio-Organism Damage under the Influence of Microwave Heating. Journal of Biosciences and Medicines, 7, 41-45. https://doi.org/10.4236/jbm.2019.74005 |
| [11] | 郑三龙. 挤压AZ31B镁合金及纯镁疲劳裂纹扩展研究[D]: [博士学位论文]. 杭州: 浙江工业大学, 2013. |
| [12] | Jo, B. and Aksan, A. (2010) Prediction of the Extent of Thermal Damage in the Cornea during Conductive Keratoplasty. Journal of Thermal Biology, 35, 167-174. https://doi.org/10.1016/j.jtherbio.2010.02.004 |
| [13] | Baldwin, S.A., Pelman, A. and Bert, J.L. (2001) A Heat Transfer Model of Thermal Balloon Endometrial Ablation. Annals of Biomedical Engineering, 29, 1009-1018. https://doi.org/10.1114/1.1415521 |
| [14] | Dodde, R.E., Bull, J.L. and Shih, A.J. (2012) Bioimpedance of Soft Tissue under Compression. Physiological Measurement, 33, 1095-1109. https://doi.org/10.1088/0967-3334/33/6/1095 |
| [15] | Hasgall, P.A., Neufeld, E., Gosselin, M.C., et al. (2012) It’s Database for Thermal and Electromagnetic Parameters of Biological Tissues. Journal of Cell Biology, 93, 170. |
| [16] | 毛琳, 陈力, 刘晨旭, 于锡潼, 宋成利. 一种联动式压力可控组织焊接电极及其应用[P]. 中国专利, CN201810891397.6. 2019-01-11. |
| [17] | Cameron, J. (1991) Physical Properties of Tissue. A Comprehensive Reference Book, Edited by Francis A. Duck. Medical Physics, 18, 834. https://doi.org/10.1118/1.596734 |
| [18] | Wu, M.P., Ou, C.S., Chen, S.L. and Yen, E.Y.T. (2000) Complications and Recommended Practices Forelectrosurgery in Laparoscopy. American Journal of Surgery, 179, 67-73. https://doi.org/10.1016/S0002-9610(99)00267-6 |
| [19] | Derman, R.D., Enel, E.C., Ferhanolu, O., et al. (2020) Effect of Heat Level and Expose Time on Denaturation of Collagen Tissues. Cel-lularand Molecular Bioengineering, 14, 113-119. https://doi.org/10.1007/s12195-020-00653-w |
| [20] | Kr？ger, M., Jaenicke, A., Winter, H., et al. (2012) Reduction of Thermal Tissue Damage Caused by Bipolar Radiofrequencyinduced Thermofusion. Biomedizinische Technik, 57, 432. https://doi.org/10.1515/bmt-2012-4318 |
| [21] | 胡钟欣, 宗乃馨, 宋成利, 周宇, 涂良勇, 毛琳. 基于射频能量的肠道组织焊接研究[J]. 医用生物力学, 2021, 36(5): 790-796. |
| [22] | Zhao, Y.X., Zeng, L.L. and Liang, T. (2017) Advances in Biocompatibility of Biodegradable Magnesium. Acta Metallurgica Sinica, 53, 1181-1196. |
| [23] | 郑玉峰, 刘彬, 顾雪楠. 可生物降解性医用金属材料的研究进展[J]. 材料导报, 2009, 23(1): 1-6. |
| [24] | Mao, L., Yuan, G., Niu, J., et al. (2013) In Vitro degradation Behavior and Biocom-patibility of Mg-Nd-Zn-Zr Alloy by Hydrofluoric acid Treatment. Materials Science and Engineering: C, 33, 242-250.
https://doi.org/10.1016/j.msec.2012.08.036 |
| [25] | Gu, X., Mao, Z., Ye, S.H., et al. (2016) Biodegradable, Elasto-meric Coatings with Controlled Anti-Proliferative Agent Release for Magnesium-Based Cardiovascular Stents. Colloids and Surfaces B: Biointerfaces, 144, 170-179.
https://doi.org/10.1016/j.colsurfb.2016.03.086 |
