Tuberculosis
infections is a serious illness and can be life threatening for patients with
hematologic malignancies. We are reporting the observations of two children
aged 7 and 5 years undergoing anticancer treatment for hematological
malignancies. The symptoms were, in the first case, cough, purulent sputum and
signs of tuberculosis impregnation, for the second case, cervical adenopathies
(PDA) with inflammatory signs. The evolution under antituberculosis treatment
was favorable for both patients, with a 5-year follow-up for the first patient
and one year for the second case. The tuberculosis did not affect chemotherapy.
The goal of our work is to specify the etio-pathogenic mechanisms, the
clinical, therapeutic and evolutionary particularities of this rare
association.
References
[1]
van de Lool, K., et al. (2018) Lymphnode Tuberculosis in a 4-Year-Old Boy with Relapsed Ganglioneuroblastoma: A Case Report. BMC Infectious Diseases, 18, Article No. 105. https://doi.org/10.1186/s12879-018-3016-x
[2]
Al-Anazi, K.A., Al-Jasser, A.M. and Evans, D.AP. (2007) Infections Caused by Mycobacterium Tuberculosis in Patients with Hematological Disorders and in Recipients of Hematopoietic Stem Cell Transplant, a Twelve Year Retrospective Study. Annals of Clinical Microbiology and Antimicrobials, 6, Article No. 16.
https://doi.org/10.1186/1476-0711-6-16
[3]
Gauchon, A., et al. (2008) Stratégie de Prise en Charge de Contages Tuberculeux Dans un Service d’oncologie-pédiatrique. Archives de Pédiatrie, 15, 236-244.
https://doi.org/10.1016/j.arcped.2008.01.005
[4]
Anibarro, L. and Pena, A. (2014) Tuberculosis in Patients with Haematological Malignancies. Mediterranean Journal of Hematology and Infectious Diseases, 6, e2014026.
https://doi.org/10.4084/mjhid.2014.026
[5]
Jain, A., et al. (2018) Analysis of Clinical Profile and Outcome of Tuberculosis in Patients with Acute Leukemia. Indian Journal of Hematology and Blood Transfusion, 34, 430-442. https://doi.org/10.1007/s12288-017-0875-z
[6]
Panda, S., et al. (2015) Disseminated Tuberculosis Presenting as Prolonged Fever without Source in a Pediatric Patient with Acute Lymphoblastic Leukemia. Journal of Cancer Research and Therapeutics, 11, 1043.
https://doi.org/10.4103/0973-1482.154030
[7]
Mishra, P., et al. (2006) Tuberculosis in Acute Leukemia: A Clinico-Hematological Profile. Hematology, 11, 335-340. https://doi.org/10.1080/10245330600915818
[8]
Billy, C. And Perronne, C. (2004) Aspects Cliniques et Thérapeutiques de la Tuberculose Chez l’enfant et l’adulte. EMC-Maladies Infectieuses, 1, 81-98.
https://doi.org/10.1016/j.emcmi.2004.01.002
[9]
Baka, M., et al. (2013) Successful Treatment in a Child with Anaplastic Large Cell Lymphoma and Coexistence of Pulmonary Tuberculosis. Hindawi Publishing Corporation Case Reports in Pediatrics, 2013, Article ID: 928701.
https://doi.org/10.1155/2013/928701
[10]
Dobler, C.C., et al. (2017) Risk of Tuberculosis in Patients with Solid Cancers and Haematological Malignancies: A Systematic Review and Meta-Analysis. European Respiratory Journal, 50, Article ID: 1700157.
https://doi.org/10.1183/13993003.00157-2017
[11]
Stefan, D.C., et al. (2008) Tuberculosis in Oncology Patients. Annals of Tropical Paediatrics, 28, 111-116. https://doi.org/10.1179/146532808X302125
[12]
Cheng, M.P., et al. (2017) Risk of Active Tuberculosis in Patients with Cancer: A Systematic Review and Meta-Analysis. Clinical Infectious Diseases, 64, 635-644.
[13]
Zivanovic, S., et al. (2010) A Case of Acute Tuberculous Pleuropneumonia in a Patient with Acute Lymphoblastic Leukemia. The Scientific World Journal, 10, 578-585. https://doi.org/10.1100/tsw.2010.52
