Background: Adiponectin possesses essential physiological functions that protect against the onset of cardiovascular and metabolic diseases. Although several studies have discussed the association between adiponectin and Blood Pressure (BP) in adults and older adolescents. To the best of our knowledge, this is the first study to explore the relationship between adiponectin and BP among children in Africa. Significance: This novel discovery is expected to serve as a benchmark for future local studies in examining the role of adiponectin in cardiovascular disorders among Africans. Method: A cross-sectional study was conducted among 86 healthy children aged 4 to 11 years with normal BMI. BP values were measured and percentiles derived from the 2017 revised clinical practice guidelines of the American Academy of Paediatrics. Fasting blood adiponectin values were determined with ELISA, and the level of statistical significance was set at p < 0.05. Result: 86 children were comprised of 42 (48.8%) males and 44 (51.2%) females. The mean age of all subjects was 7.5 ± 2.3 years, while that of fasting adiponectin was 4.8 ± 2.1 ng/dl. There were no significant differences in the age, Body Mass Index, BP and adiponectin concentrations across gender. 69 (80.2%) participants had normal BP while 5 (5.8%) and 12 (14.0%) had elevated BP and stage 1 hypertension. Mean adiponectin values for normal BP, elevated BP and stage 1 hypertension were 5.1 ± 2.1 ng/ml, 3.3 ± 1.2 ng/ml and 4.1 ± 1.9 ng/ml respectively (p-value = 0.039). A significant negative correlation was observed between adiponectin and systolic BP independent of age, sex, and BMI. Although a negative correlation was noted between adiponectin and diastolic blood pressure, this was not statistically significant. Conclusion: Adiponectin correlates negatively with systolic BP in young Nigerian children independent of age, Body Mass Index and gender. More studies are indicated to investigate this relationship in association with vital metabolic factors across different age groups in Africa.
References
[1]
Trujillo, M.E. and Scherer, P.E. (2005) Adiponectin—Journey from an Adipocyte Secretory Protein to Biomarker of the Metabolic Syndrome. Journal of Internal Medicine, 257, 167-175. https://doi.org/10.1111/j.1365-2796.2004.01426.x
[2]
Miljkovic-Gacic, I., Wang, X., Kammerer, C.M., Bunker, C.H., Wheeler, V.W., Patrick, A.L., et al. (2007) Genetic Determination of Adiponectin and Its relationship with Body Fat Topography in Multigenerational Families of African Heritage. Metabolism, 56, 234-238. https://doi.org/10.1016/j.metabol.2006.09.019
[3]
Menzaghi, C., Trischitta, V. and Doria, A. (2007) Genetic Influences of Adiponectin on Insulin Resistance, Type 2 Diabetes, and Cardiovascular Disease. Diabetes, 56, 1198-1209. https://doi.org/10.2337/db06-0506
[4]
Gil-Campos, M., Cañete, R.R. and Gil, A. (2004) Adiponectin, the Missing Link in Insulin resistance and Obesity. Clinical Nutrition, 23, 963-974. https://doi.org/10.1016/j.clnu.2004.04.010
[5]
Hug, C. and Lodish, H.F. (2005) The Role of the Adipocyte Hormone Adiponectin in Cardiovascular Disease. Current Opinion in Pharmacology, 5, 129-134.
[6]
Chigom, E. (1988) Noncommunicable Diseases. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases
[7]
Chen, X.L. and Wang, Y.F. (2008) Tracking of Blood Pressure from Childhood to Adulthood: A Systematic Review and Meta-Regression Analysis. Circulation, 117, 3171-3180. https://doi.org/10.1161/CIRCULATIONAHA.107.730366
[8]
Sun, S.S., Grave, G.D., Siervogel, R.M., Pickoff, A.A., Arslanian, S.S. and Daniels, S.R. (2007) Systolic Blood Pressure in Childhood Predicts Hypertension and Metabolic Syndrome Later in Life. Pediatrics, 119, 237-246. https://doi.org/10.1542/peds.2006-2543
[9]
Kim, D.H., Kim, C., Ding, E.L., Townsend, M.K. and Lipsitz, L.A. (2013) Adiponectin Levels and the Risk of Hypertension: A Systematic Review and Meta-Analysis. Hypertension, 62, 27-32. https://doi.org/10.1161/HYPERTENSIONAHA.113.01453
[10]
Lambert, M., O’Loughlin, J., Delvin, E.E., Levy, E., Chiolero, A. and Paradis, G. (2009) Association between Insulin, Leptin, Adiponectin and Blood Pressure in Youth. Journal of Hypertension, 27, 1025-1032. https://doi.org/10.1097/HJH.0b013e32832935b6
[11]
Kaze, A.D., Musani, S.K., Bidulescu, A., Correa, A., Golden, S.H., Bertoni, A.G., et al. (2021) Plasma Adiponectin and Blood Pressure Progression in African Americans: The Jackson Heart Study. American Journal of Hypertension, 34, 1163-1170. https://doi.org/10.1093/ajh/hpab101
[12]
De Las Heras, J., Lee, S., Bacha, F., Tfayli, H. and Arslanian, S. (2011) Cross-Sectional Association between Blood Pressure, In Vivo Insulin Sensitivity and Adiponectin in Overweight Adolescents. Hormone Research in Paediatrics, 76, 379-385. https://doi.org/10.1159/000331462
[13]
Shatat, I.F., Freeman, K.D., Vuguin, P.M., Dimartino-Nardi, J.R. and Flynn, J.T. (2009) Relationship between Adiponectin and Ambulatory Blood Pressure in Obese Adolescents. Pediatric Research, 65, 691-695. https://doi.org/10.1203/PDR.0b013e31819ea776
[14]
Wang, H., Necheles, J., Birne, J.S., Li, Z., Xing, H., Tang, G., et al. (2012) Association of Adipokines with Blood Pressure in Rural Chinese Adolescents. Journal of Human Hypertension, 26, 493-501. https://doi.org/10.1038/jhh.2011.64
[15]
Gómez-Díaz, R.A., Rodríguez-Moran, M., Mondragón-González, R., Wacher, N.H. and Guerrero-Romero, F. (2019) Adipocytokines and High Blood Pressure in Mexican Children. Endocrine Research, 44, 159-167. https://doi.org/10.1080/07435800.2019.1610771
[16]
Yuyun, M.F., Sliwa, K., Kengne, A.P., Mocumbi, A.O. and Bukhman, G. (2020) Cardiovascular Diseases in Sub-Saharan Africa Compared to High-Income Countries: An Epidemiological Perspective. Global Heart, 15, 15.
Eyong, M.E., Ntia, H.U., Ikobah, J.M., Eyong, E.M., Uket, H., Enyuma, C., et al. (2018) Pattern of Pubertal Changes in Calabar, South South Nigeria. The Pan African Medical Journal, 31, Article No. 20.
[19]
Nri-Ezedi, C.A., Ulasi, T., Chukwuka, J., Okpara, H., Ofiaeli, O., Nwaneli, E., et al. (2021) Serum Total Adiponectin in Healthy Pre-Pubertal Nigerian School Children. Nigerian Journal of Clinical Practice, 24, 821-827. https://doi.org/10.4103/njcp.njcp_427_20
[20]
Defining Childhood Weight Status. BMI for Children and Teens. CDC. https://www.cdc.gov/obesity/childhood/defining.html
[21]
Child & Teen BMI Calculator. CDC. https://www.cdc.gov/healthyweight/bmi/calculator.html
[22]
ELISAs and ELISA Kits. Elabscience. https://www.elabscience.com/Products-elisa_kits-61.html
[23]
Ohashi, K., Ouchi, N. and Matsuzawa, Y. (2011) Adiponectin and Hypertension. American Journal of Hypertension, 24, 263-269. https://doi.org/10.1038/ajh.2010.216
[24]
Yiannikouris, F., Gupte, M., Putnam, K. and Cassis, L. (2010) Adipokines and Blood Pressure Control. Current Opinion in Nephrology and Hypertension, 19, 195-200. https://doi.org/10.1097/MNH.0b013e3283366cd0
[25]
Tanida, M., Shen, J., Horii, Y., Matsuda, M., Kihara, S., Funahashi, T., et al. (2007) Effects of Adiponectin on the Renal Sympathetic Nerve Activity and Blood Pressure in Rats. Experimental Biology and Medicine, 232, 390-397.
[26]
Watanabe, S., Okura, T., Kurata, M., Irita, J., Manabe, S., Miyoshi, K., et al. (2006) The Effect of Losartan and Amlodipine on Serum Adiponectin in Japanese Adults with Essential Hypertension. Clinical Therapeutics, 28, 1677-1685. https://doi.org/10.1016/j.clinthera.2006.10.012
[27]
Ran, J., Hirano, T., Fukui, T., Saito, K., Kageyama, H., Okada, K., et al. (2006) Angiotensin II Infusion Decreases Plasma Adiponectin Level via Its Type 1 Receptor in Rats: An Implication for Hypertension-Related Insulin Resistance. Metabolism, 55, 478-488. https://doi.org/10.1016/j.metabol.2005.10.009
[28]
Mallamaci, F., Zoccali, C., Cuzzola, F., Tripepi, G., Cutrupi, S., Parlongo, S., et al. (2002) Adiponectin in Essential Hypertension. Journal of Nephrology, 15, 507-511.
[29]
Morrison, J.A., Glueck, C.J., Daniels, S., Wang, P. and Stroop, D. (2011) Paradoxically High Adiponectin in Obese 16-Year-Old Girls Protects against Appearance of the Metabolic Syndrome and Its Components Seven Years Later. The Journal of Pediatrics, 158, 208-214.E1. https://doi.org/10.1016/j.jpeds.2010.08.012
[30]
Semple, R.K., Halberg, N.H., Burling, K., Soos, M.A., Schraw, T., Luan, J., et al. (2007) Paradoxical Elevation of High-Molecular Weight Adiponectin in Acquired Extreme Insulin Resistance Due to Insulin Receptor Antibodies. Diabetes, 56, 1712-1717. https://doi.org/10.2337/db06-1665
[31]
Menzaghi, C. and Trischitta, V. (2018) The Adiponectin Paradox for All-Cause and Cardiovascular Mortality. Diabetes, 67, 12-22. https://doi.org/10.2337/dbi17-0016
[32]
Snehalatha, C., Yamuna, A. and Ramachandran, A. (2008) Plasma Adiponectin Does Not Correlate with Insulin Resistance and Cardiometabolic Variables in Nondiabetic Asian Indian Teenagers. Diabetes Care, 31, 2374-2379. https://doi.org/10.2337/dc08-1083
[33]
Ivković, V., Jelaković, M., Laganović, M., Pećin, I., Vrdoljak, A., Karanović, S., et al. (2014) Adiponectin Is Not Associated with Blood Pressure in Normotensives and Untreated Hypertensives with Normal Kidney Function. Medicine, 93, e250. https://doi.org/10.1097/MD.0000000000000250
