Background: The aim of the current study was to assess fifteen-year life expectancy, cardiovascular events,fate of the limb, and risk factors with orwithout polyvascular disease in patients with Peripheral Arterial Disease(PAD). Methods: We conducted a prospective cohort study in 1019 PAD patients. The endpoints were Cardiovascular or Cerebrovascular Death (CCVD), All-Cause Death (ACD), Major Adverse Cardiovascular Events (MACE), and Cardiovascular and/or Limb Events (CVLE). Results: The patients who died were？539 (52.9%) during follow-up periods. The rate of CCVD was 50.5% (n =？272). In multiple regression analysis, the number of affected arteries had correlations with estimated Glomerular Filtration Rate (eGFR), HDL-cholesterol,？Ankle Brachial Pressure Index (ABI), and diabetes (p < 0.05). In multiple logistic analysis, PAD with Cerebrovascular Disease (CVD) was correlated with older？age, ABI, eGFR, and atrial fibrillation (p < 0.05); PAD with Coronary Heart？Disease (CHD) was correlated with younger age, eGFR, HDL-cholesterol,？LDL-cholesterol, and diabetes (p < 0.05); and triple vascular disease (PAD with？CVD and CHD) was correlated with ABI, eGFR, HDL-cholesterol, and diabetes (p？< 0.05).The number of affected arteries had significant correlations with？CCVD, ACD, MACE, and CVLE
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