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Medical Diagnosis 2021
Hippo信号通路在消化系统肿瘤中的研究进展
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Abstract:
Hippo信号通路自上世纪末被发现以来就被持续关注，目前已被证实在多种动物细胞生长、增殖中均起到重要调控作用。在临床常见消化系统肿瘤中，多项实验证明Hippo信号通路在肿瘤细胞的发生、增殖、侵袭和转移中有着重要影响。在Hippo信号通路各部分组成因子中，核心因子YAP的激活及表达可明显促进多种正常及肿瘤细胞的增殖。Hippo信号通路中的核心及相关因子或可成为将来肿瘤靶向治疗药物的目标因子。本文就Hippo信号通路在临床常见消化系统肿瘤中的作用展开论述。
Hippo signaling pathway has been continuously concerned since it was discovered at the end of last century. At present, it has been proved to play an important regulatory role in the growth and proliferation of a variety of animal cells. In common clinical digestive system tumors, many experiments have proved that Hippo signaling pathway has an important impact on the occurrence, proliferation, invasion and metastasis of tumor cells. Among the components of Hippo signaling pathway, the activation and expression of core factor Yap can significantly promote the proliferation of a variety of normal and tumor cells. The core and related factors in Hippo signaling pathway may become the target factors of tumor targeted therapeutic drugs in the future. This paper discusses the role of Hippo signaling pathway in common clinical digestive system tumors.
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