|
|
葛根超声雾化对干眼患者泪液分泌、泪膜破裂时间及泪液中IL-1β的影响
|
Abstract:
目的：观察葛根超声雾化对干眼患者泪液中炎症因子、泪液分泌量和泪膜破裂时间的影响。方法：连续收集2020.06~2020.12在我院门诊确诊为双眼干眼的患者42例(84眼)作为研究对象，随机分为对照组和观察组，对照组给予玻璃酸钠滴眼液点眼联合灭菌注射用水超声雾化熏眼，观察组给予玻璃酸钠滴眼液点眼联合葛根煎剂超声雾化熏眼。分别于治疗前和治疗3周后测定泪液中IL-1β的质量浓度、泪膜破裂时间、泪液分泌量、角膜荧光染色评分，评估两种方法的疗效。结果：观察组的泪液分泌量、泪膜破裂时间大于对照组(P < 0.05)，角膜荧光染色评分及泪液中IL-1β的质量浓度均低于对照组(P < 0.05)。结论：葛根超声雾化治疗干眼可延长泪膜破裂时间、增加泪液分泌量、降低IL-1β的质量浓度，促进角膜修复，值得推广应用。
Objective: To study the effect of Gegen fumigation on tear secretion, breakup time of tear film and IL-1β in tears in patients with dry eyes. Methods: A total of forty-two patients with dry eyes in our hospital were continuously collected as the study subjects. They were randomly divided into control and observation groups. The control group used sodium hyaluronate eye drops and sterilized water for injection, while the observation group used sodium hyaluronate eye drops and Gegen atomized eyes. The mass concentration of IL-1β, breakup time of tear film, tear secretion, and corneal fluorescence staining score were determined in tears before and after 3 weeks of treatment, respectively. Results: Tear secretion and breakup time of tear film were greater than in the control group (P < 0.05). Corcorneal fluorescence staining score and mass concentration of IL-1β in tears were lower than in control groups (P < 0.05). Conclusion: Using Gegen atomization treatment of dry eyes can extend the time of tear membrane rupture, increase tear secretion, reduce the quality concentration of IL-1β, and promote corneal repair, which is worth promotion and application.
| [1] | 亚洲干眼协会中国分会, 海峡两岸医药卫生交流协会眼科学专业委员会眼表与泪液病学组, 中国医师协会眼科医师分会眼表与干眼学组. 中国干眼专家共识: 定义和分类(2020年) [J]. 中华眼科杂志, 2020, 56(6): 418-422. |
| [2] | Malik, A.S., Boyko, O., Atkar, N. and Young, W.F. (2001) A Comparative Study of MR Imaging Profile of Titanium Pedicle Screws. Acta Radiologica, 42, 291-293. https://doi.org/10.1080/028418501127346846 |
| [3] | Wu, X., Chen, X., Ma, Y., et al. (2020) Analysis of Tear Inflammatory Molecules and Clinical Correlations in Evaporative Dry Eye Disease Caused by Meibomian Gland Dysfunction. International Ophthalmology, 40, 3049-3058.
https://doi.org/10.1007/s10792-020-01489-z |
| [4] | Clayton, J.A. (2018) Dry Eye. The New England Journal of Medicine, 378, 2212-2223.
https://doi.org/10.1056/NEJMra1407936 |
| [5] | 李宝花, 宁博彪, 魏宇娇, 等. TLRs信号通路在干眼发病机制中的研究进展[J]. 国际眼科杂志, 2021, 21(5): 827-831. |
| [6] | 蒋鹏飞, 黎冬冬, 彭俊, 等. 干眼症患者泪液炎症因子与症状体征相关性研究[J]. 国际眼科杂志, 2020, 20(4): 699-702. |
| [7] | Deng, Y., Chen, W., Xiao, P., et al. (2020) Conjunctival Microvascular Responses to Anti-Inflammatory Treatment in Patients with Dry Eye. Microvascular Research, 131, 104033. https://doi.org/10.1016/j.mvr.2020.104033 |
| [8] | Periman, L.M., Perez, V.L., Saban, D.R., et al. (2020) The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options. Journal of Ocular Pharmacology and Therapeutics, 36, 137-146.
https://doi.org/10.1089/jop.2019.0060 |
| [9] | 李能, 来坚. 氟米龙联合玻璃酸钠滴眼液治疗干眼的效果及对泪液中炎症因子的影响[J]. 国际眼科杂志, 2021, 21(3): 509-514. |
| [10] | 中华医学会眼科学分会角膜病学组. 干眼临床诊疗专家共识(2013年) [J]. 中华眼科杂志, 2013, 49(1): 73-75. |
| [11] | Li, B., Tian, Y. And Wang, S. (2020) The Correlation of Cytokines and Sensory Hypersensitivity in Mild Dry Eye Patients Characterized by Symptoms Outweighing Signs. Molecular Vision, 26, 359-369. |
| [12] | Schargus, M., Geerling, G. and Joachim, S.C. (2018) Significance of New Methods of Examining the Tear Film in Dry Eye Disease: Tear Film Osmolarity and Matrix Metalloproteinases (MMP-9). Klinische Monatsbl？tter für Augenheilkunde, 235, 597-602. |
| [13] | 陈艳, 文佳玉, 谢晓芳, 彭成. 葛根的化学成分及药理作用研究进展[J]. 中药与临床, 2021, 12(1): 53-60. |
| [14] | 柏琳, 邹天琪, 张成义. 葛根总黄酮对佐剂性关节炎大鼠免疫器官指数、IL-1β及TNF-α的影响分析[J]. 吉林医学, 2021, 42(6): 1298-1300. |
| [15] | 杨新颖. 葛根素药理活性研究进展[J]. 科学技术创新, 2020(8): 194-195. |
