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硫代硫酸钠在钙化防御中的机制和临床应用
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Abstract:
钙化防御，又名钙性尿毒症性小动脉病(calcific uremic arteriopathy, CUA)，是一种发生于终末期肾脏病患者中的罕见的、致死性高的血管钙化性疾病，其早期临床症状不典型，预后差，且缺乏明确的临床指南。目前，在临床上，对于钙化防御的治疗主要是采用以硫代硫酸钠(Sodium thiosulfate, STS)为主的综合治疗。硫代硫酸钠治疗钙化防御主要通过钙螯合、抗氧化应激、酸中毒、舒张血管和抗炎镇痛作用及钙化抑制因子作用等机制，而随着临床研究的进展，关于这些治疗机制尚存在一些争议。
Calciphylaxis, also known as calcium uremic arteriosis, is a special vascular calcification in patients with end-stage kidney disease which has atypical early clinical symptoms, poor prognosis, and unclear clinical guidelines. At present, sodium thiosulfate (STS) is the most commonly recommended drug in treatment of calciphylaxis which plays a role mainly through the mechanisms of calcium chelation, antioxidant stress, acidosis, vasodilation, anti-inflammatory and analgesic effects, and calcification inhibitors. However, there are still some controversies about these therapeutic mechanisms with the progress of clinical research.
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