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肿瘤耐药机制的研究进展
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Abstract:
癌症的发病率每年呈上升趋势，随着手术、放疗、化疗水平的提高，恶性肿瘤患者生存率有了较大提高，然而，在化疗过程中部分患者通过内源性或获得性机制对化疗药物产生耐受，严重制约了化疗效果，影响预后。因此，通过对肿瘤耐药机制的研究，对于制定合理的化疗方案，采取有针对性的干预措施，提高生存率至关重要。本文就导致肿瘤耐药的机制相关研究进展作一回顾性总结。
The incidence rate of cancer is increasing every year. With the improvement of operation, radiotherapy and chemotherapy, the survival rate of malignant tumor patients has been greatly improved. However, in some chemotherapy patients, the tolerance of chemotherapeutic drugs through endogenous or acquired mechanisms has seriously restricted the effect of chemotherapy and the prognosis. Therefore, through the study of the mechanism of tumor drug resistance, it is very important to formulate a reasonable chemotherapy scheme, take targeted intervention measures and improve the survival rate. This paper reviews the research progress on the mechanism of tumor drug resistance.
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