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早发冠心病相关标志物的临床意义
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Abstract:
近几年来，社会经济迅速发展，各种疾病的分布结构有了明显改变，特别是冠心病的风险发生率和病死率有逐年增加以及年轻人化的趋势。早发冠心病(PCAD)患者是冠心病的一个特殊人群构成，多数患者负担重，远期预后差。而一些传统标志物不能完全解释其病理生理机制，对新的生物标志物的评估显得越来越有必要，这些新的生物标记物可能有助于识别更易患早发冠心病的人。
In recent years, with the rapid development of social economy, the distribution structure of various diseases has changed significantly, especially the risk rate and mortality of coronary heart disease has increased year by year and the trend of young people. Patients with premature coronary heart disease (PCAD) are a special group of patients with coronary heart disease, most of whom have a heavy burden and poor long-term prognosis. While some traditional markers cannot fully explain the pathophysiological mechanisms, there is an increasing need to evaluate new biomarkers that may help identify people at higher risk of early-onset coronary heart disease.
| [1] | Ahmed, Z., Corina, I., Aakash, D., Kathir, B. and Kai, C. (2019) Methylenetetrahydrofolate Reductase Polymorphism and Premature Coronary Artery Disease. Cureus, 11, e5014. https://doi.org/10.7759/cureus.5014 |
| [2] | Ma, Y., Peng, D.L., Liu, C.G., Huang, C. and Luo, J. (2017) Serum High Concentrations of Homocysteine and Low Levels of Folic Acid and Vitamin B 12 Are Significantly Correlated with the Categories of Coronary Artery Diseases. BMC Cardiovascular Disorders, 17, 37. https://doi.org/10.1186/s12872-017-0475-8 |
| [3] | 江灿灿, 程景林, 刘奕, 刘泽岩. 血浆同型半胱氨酸水平与早发冠心病患者冠脉病变特点的相关性分析[J]. 临床医学研究与实践, 2020, 5(11): 39-40. |
| [4] | Hou, X.W., Chen, X. and Shi, J.P. (2015) Genetic Polymorphism of MTHFR C677T and Premature Coronary Artery Disease Susceptibility: A Meta-Analysis. Gene, 565, 39-44. https://doi.org/10.1016/j.gene.2015.03.062 |
| [5] | 付霄霄, 颜涛. 同型半胱氨酸与冠心病血管损伤病变机制的研究进展[J]. 当代医学, 2020, 26(17): 188-191. |
| [6] | 赵慧敏, 雷自立, 郭姣. 脂联素水平与2型糖尿病及心血管疾病矛盾性关系的研究进展[J]. 中国细胞生物学报, 2018, 40(5): 820-826. |
| [7] | Yanai, H. and Yoshida, H. (2019) Beneficial Effects of Adiponectin on Glucose and Lipid Metabolism and Atherosclerotic Progression: Mechanisms and Perspectives. International Journal of Molecular Sciences, 20, 1190.
https://doi.org/10.3390/ijms20051190 |
| [8] | 王萍, 曾敏, 吴智勇, 蒙绪卿, 符秀虹, 何扬利, 陈积雄, 刘肖君. 冠心病患者血浆脂联素水平变化及其与冠状动脉病变的关系[J]. 山东医药, 2017, 57(12): 51-53. |
| [9] | Ambroziak, M., Kolanowska, M., Bartoszewicz, Z. and Budaj, A. (2018) Adiponectin Gene Variants and Decreased Adiponectin Plasma Levels Are Associated with the Risk of Myocardial Infarction in Young Age. Gene, 642, 498-504.
https://doi.org/10.1016/j.gene.2017.11.064 |
| [10] | 张闽, 彭瑜, 吕树铮. 脂联素基因多态性与早发心肌梗死的相关性研究[J]. 中华心血管病杂志, 2016, 44(7): 577-582. |
| [11] | Cho, S., et al. (2015) The Additive Value of Multiple Biomarkers in Prediction of Premature Coronary Artery Disease. Acta Cardiologica, 70, 205-210. https://doi.org/10.1080/AC.70.2.3073512 |
| [12] | Li, S.S., Pan, G.J., Chen, H.L. and Niu, X.H. (2019) Determination of Serum Homocysteine and Hypersensitive C-Reactive Protein and Their Correlation with Premature Coronary Heart Disease. The Heart Surgery Forum, 22, E215-E217. https://doi.org/10.1532/hsf.2223 |
| [13] | Tabakc？, M.M., Gerin, F., Sunbul, M., et al. (2017) Relation of Plasma Fibrinogen Level with the Presence, Severity, and Complexity of Coronary Artery Disease. Clinical and Applied Thrombosis/Hemostasis, 23, 638-644.
https://doi.org/10.1177/1076029616629210 |
| [14] | Mjelva, ？.R., et al. (2018) Fibrinogen and Neopterin Is Associated with Future Myocardial Infarction and Total Mortality in Patients with Stable Coronary Artery Disease. Thrombosis and Haemostasis, 118, 778-790. |
| [15] | 沙璐琳, 刘和俊. 血浆纤维蛋白原和血尿酸水平与早发冠心病的相关性[J]. 心血管康复医学杂志, 2017, 26(2): 154-158. |
| [16] | Huang, Y.L., et al. (2018) Gamma-Glutamyltransferase and Risk of Acute Coronary Syndrome in Young Chinese Patients: A Case-Control Study. Disease Markers, 2018, Article ID: 2429160. https://doi.org/10.1155/2018/2429160 |
| [17] | Ndrepepa, G., Colleran, R. and Kastrati, A. (2018) Gamma-Glutamyl Transferase and the Risk of Atherosclerosis and Coronary Heart Disease. Clinica Chimica Acta, 476, 130-138. https://doi.org/10.1016/j.cca.2017.11.026 |
| [18] | 李俊丽, 韩清华. γ-谷氨酰转移酶与早发冠心病的相关性研究[J]. 中华临床医师杂志(电子版), 2017, 11(7): 1095-1098. |
| [19] | 马煜盛. 脂蛋白(a)与冠心病风险及严重程度关系的研究[D]: [博士学位论文]. 广州: 南方医科大学, 2019. |
| [20] | 石艳璞, 曹晔萱, 靳景璐, 刘慧慧, 郭远林, 吴娜琼, 朱成刚, 刘庚, 董倩, 李建军. 血浆脂蛋白(a)浓度与青年人群冠心病关系的横断面研究[J]. 中国循环杂志, 2020, 35(4): 343-348. |
| [21] | Mobarek, D., Karasik, P.A., Tomer, M. and Miller, M. (2019) High Lp(a) Associated with Very Premature Coronary Heart Disease. Journal of Clinical Lipidology, 13, 402-404. https://doi.org/10.1016/j.jacl.2019.03.003 |
