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FoxM1在肝胆系统恶性肿瘤中的作用及研究进展
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Abstract:
FoxM1 (Forkhead box Protein M1)是一种重要的、具有调节细胞增殖分裂等重要作用的转录因子。在多种肿瘤组织中表达量较正常组织明显增高，并且与肿瘤异质性以及耐药性密切相关。相关研究表明FoxM1可通过促进肿瘤血管生成、调节能量代谢、调控信号转导通路等影响肿瘤细胞的增殖、浸润、转移。本文主要介绍FoxM1在肝胆系统肿瘤中的作用及研究新进展，为临床上肝胆系肿瘤的诊断及治疗提供新的理论依据及新的药物作用靶点。
Forkhead box Protein M1 (FoxM1) is an important transcription factor that regulates cell proliferation and division. The expression level in various tumor tissues was significantly higher than that in normal tissues, and was closely related to tumor heterogeneity and drug resistance. Related studies have shown that FoxM1 can affect the proliferation, invasion and metastasis of tumor cells by promoting tumor angiogenesis, regulating energy metabolism and regulating signal transduction pathways. This article mainly introduces the role and new progress of FoxM1 in hepatobiliary system tumors, providing new theoretical basis and new drug targets for clinical diagnosis and treatment of hepatobiliary system tumors.
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