女性甲状腺乳头状癌患者共患乳腺癌的临床病理特征分析
Analysis of Clinicopathological Characteristics of Papillary Thyroid Cancer with Breast Cancer in Female Patients

目的：通过对共患甲状腺乳头状癌(PTC)和乳腺癌女性患者的甲状腺乳头状癌临床病理特征进行分析，探究女性甲状腺乳头状癌患者共患乳腺癌的相关因素。方法：选取PTC的女性患者428例，其中单纯PTC患者327例，PTC合并乳腺癌患者101例，收集PTC的临床病理资料，分析比较两组间的临床及病理特征。结果：甲状腺乳头状癌共患乳腺癌组的年龄、肿瘤大小、包膜浸润率、颈部淋巴结转移率有统计学意义(均P < 0.05)。多因素Logistic回归分析显示，PTC患者共患乳腺癌的风险与年龄(OR = 1.056，95% CI为1.030~1.082)呈正相关，与肿瘤大小(OR = 0.466，95% CI为0.275~0.725)、颈部淋巴结转移率(OR = 0.562，95% CI为0.324~0.975)呈负相关。结论：年龄增大可增加PTC共患乳腺癌的风险；共患乳腺癌的PTC患者相较于单纯PTC患者而言，PTC的肿瘤小，淋巴结转移率较低。
Objective: We analyzed the clinicopathological characteristics of papillary thyroid cancer (PTC) in female papillary thyroid cancer patients with breast cancer, to investigate the relevant factors of papillary thyroid cancer with breast cancer. Methods: 428 female PTC patients were selected in the retrospective research, of which 327 were patients with simple PTC, 101 were patients with PTC combined breast cancer. We retrospectively analyzed the clinical and pathological data of simple PTC and PTC with breast cancer. Results: There were significant differences in the age, tumor size, extrathyroidal extension rate and neck lymph node metastasis rate between the group of patients with PTC alone and PTC patients with prime breast cancer (p < 0.05). Multifactor Logistic regression analysis showed that the age (OR = 1.056, 95% CI were 1.030~1.082) were positively correlated with the risk of prime breast cancer in female patients with PTC, and the tumor size (OR = 0.466, 95% CI were 0.275~0.725), and neck lymph node metastasis rate (OR = 0.562, 95% CI were 0.324~0.975) were negatively correlated. Conclusion: Older age may increase the risk of breast cancer in PTC patients, and PTC patients with breast cancer have smaller tumors and lower lymph node metastasis than those with PTC only.