|
|
血管性认知障碍的研究进展
|
Abstract:
血管性疾病导致的认知功能损伤被认为是痴呆的第二大常见原因，随着发病率的攀升，给社会及家庭带来沉重的经济负担。血管性认知障碍是一个影响因素混杂且机制不完全明了的综合症，但同时也是一个可以预防并有效治疗的综合症，更好地认识其病理生理机制及影像学特征并尽早诊治具有重要意义。
Cognitive impairment caused by vascular diseases is considered to be the second most common cause of dementia. With the incidence rate increasing, heavy financial burden has been brought to the society and family. Vascular cognitive impairment is a syndrome with mixed influencing factors and incomplete mechanism, but it is also a syndrome that can be prevented and effectively treated. Therefore, it is of great significance to better understand its pathophysiological mechanism and imaging characteristics and make diagnosis and treatment as soon as possible.
| [1] | Hachinski, V., Iadecola, C., Peterse, R.C., et al. (2007) National Institute of Neurological Disorders and Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards. Stroke, 37, 2220-2241. |
| [2] | Rockwood, K., Howard, K., MacKnight, C., et al. (1999) Spectrum of Disease in Vascular Cognitive Impairment. Neuroepidemiology, 18, 248-254. https://doi.org/10.1159/000026219 |
| [3] | van der Flier, W.M., Skoog, I., Schneider, J.A., et al. (2018) Vascular Cognitive Impairment. Nature Reviews Disease Primers, 4, 2159-2161. https://doi.org/10.1038/nrdp.2018.3 |
| [4] | 张守字. 血管性认知障碍的诊断与治疗[J]. 中国临床保健杂志, 2020, 23(2): 161-164. |
| [5] | (2018) Alzheimer’s Disease Facts and Figures. Alzheimer’s & Dementia, 14, 367-429.
https://doi.org/10.1016/j.jalz.2018.02.001 |
| [6] | Shprakh, V.V. and Suvorova, I.A. (2010) Risk Factors and Prediction of Poststroke Dementia. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova, 110, 3-10. |
| [7] | Velayudhan, L. (2011) Principles and Practice of Geriatric Psychiatry (3rd Edition). International Psychogeriatrics, 24, 1021-1022. https://doi.org/10.1017/S1041610211002407 |
| [8] | Goodman, R.A., Lochner, K.A., Thambisetty, M., et al. (2017) Prevalence of Dementia Subtypes in United States Medicare Fee-for-Service Beneficiaries, 2011-2013. Alzheimer’s & Dementia, 13, 28-37.
https://doi.org/10.1016/j.jalz.2016.04.002 |
| [9] | D’Souza, C.E., Greenway, M.R.F., Graff-Radford, J., et al. (2021) Cognitive Impairment in Patients with Stroke. Seminars in Neurology, 41, 75-84. https://doi.org/10.1055/s-0040-1722217 |
| [10] | Skrobot, O.A., Black, S.E., Chen, C., et al. (2018) Progress toward Standardized Diagnosis of Vascular Cognitive Impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study. Alzheimer’s & Dementia, 14, 280-292. |
| [11] | 2019年中国血管性认知障碍诊治指南[J]. 中华医学杂志, 2019(35): 2737-2744. |
| [12] | Mascitelli, L. and Pezzetta, F. (2006) Mild Cognitive Impairment. The Lancet, 367, 1980.
https://doi.org/10.1016/S0140-6736(06)68882-X |
| [13] | 马玉梅, 邓斌, 亓斐, 等. 老年脑小血管病患者血浆生化指标及蛋白尿的变化特点[J]. 解放军医学杂志, 2019, 44(8): 676-681. |
| [14] | Du, J. and Xu, Q. (2019) Neuroimaging Studies on Cognitive Impairment Due to Cerebral Small Vessel Disease. Stroke and Vascular Neurology, 4, 99-101. https://doi.org/10.1136/svn-2018-000209 |
| [15] | Dichgans, M. and Leys, D. (2017) Vascular Cognitive Impairment. Circulation Research, 120, 573-591.
https://doi.org/10.1161/CIRCRESAHA.116.308426 |
| [16] | Suzuki, H., Venkataraman, A.V., Bai, W., et al. (2019) Associations of Regional Brain Structural Differences with Aging, Modifiable Risk Factors for Dementia, and Cognitive Performance. JAMA Network Open, 2, e1917257.
https://doi.org/10.1001/jamanetworkopen.2019.17257 |
| [17] | 吴冰远, 耿左军. 血管性认知障碍的MRI研究进展[J]. 国际医学放射学杂志, 2020, 43(6): 653-658. |
| [18] | Carnevale, L. and Lembo, G. (2019) Innovative MRI Techniques in Neuroimaging Approaches for Cerebrovascular Diseases and Vascular Cognitive Impairment. International Journal of Molecular Sciences, 20, 2656.
https://doi.org/10.3390/ijms20112656 |
| [19] | Banerjee, G., Wilson, D., Jager, H.R., et al. (2016) Novel Imaging Techniques in Cerebral Small Vessel Diseases and Vascular Cognitive Impairment. Biochimica et Biophysica Acta, 1862, 926-938.
https://doi.org/10.1016/j.bbadis.2015.12.010 |
| [20] | 陈苏杰, 徐舟, 邱昱旻. MRI与CT影像检查在老年多发性脑梗死诊断中的比较分析[J]. 影像研究与医学应用, 2020, 4(17): 205-206. |
| [21] | Chen, X., Wang, J., Shan, Y., et al. (2019) Cerebral Small Vessel Disease: Neuroimaging Markers and Clinical Implication. Journal of Neurology, 266, 2347-2362. https://doi.org/10.1007/s00415-018-9077-3 |
| [22] | Smith, E.E. and Beaudin, A.E. (2018) New Insights into Cerebral Small Vessel Disease and Vascular Cognitive Impairment from MRI. Current Opinion in Neurology, 31, 36-43. https://doi.org/10.1097/WCO.0000000000000513 |
| [23] | van der Flier, W.M., Skoog, I., Schneider, J.A., et al. (2018) Vascular Cognitive Impairment. Nature Reviews Disease Primers, 4, 18003-18018. https://doi.org/10.1038/nrdp.2018.3 |
| [24] | Dichgans, M. (2009) Cognition in CADASIL. Stroke, 40, S45-S47. https://doi.org/10.1161/STROKEAHA.108.534412 |
| [25] | Chabriat, H., Joutel, A., Dichgans, M., et al. (2009) CADASIL. The Lancet Neurology, 8, 643-653.
https://doi.org/10.1016/S1474-4422(09)70127-9 |
| [26] | Sherva, R., Gross, A., Mukherjee, S., et al. (2020) Genome-Wide Association Study of Rate of Cognitive Decline in Alzheimer’s Disease Patients Identifies Novel Genes and Pathways. Alzheimer’s & Dementia Journal, 16, 1134-1145.
https://doi.org/10.1002/alz.12106 |
| [27] | Bersano, A., Lanfranconi, S., Valcarenghi, C., et al. (2012) Neurological Features of Fabry Disease: Clinical, Pathophysiological Aspects and Therapy. Acta Neurologica Scandinavica, 126, 77-97.
https://doi.org/10.1111/j.1600-0404.2012.01661.x |
| [28] | Arvanitakis, Z., Leurgans, S.E., Wang, Z., et al. (2011) Cerebral Amyloid Angiopathy Pathology and Cognitive Domains in Older Persons. Annals of Neurology, 69, 320-327. https://doi.org/10.1002/ana.22112 |
| [29] | Viswanathan, A., Patel, P., Rahman, R., et al. (2008) Tissue Microstructural Changes Are Independently Associated with Cognitive Impairment in Cerebral Amyloid Angiopathy. Stroke, 39, 1988-1992.
https://doi.org/10.1161/STROKEAHA.107.509091 |
| [30] | Kim, Y., Kong, M. and Lee, C. (2013) Association of Intronic Sequence Variant in the Gene Encoding Spleen Tyrosine Kinase with Susceptibility to Vascular Dementia. World Journal of Biological Psychiatry, 14, 220-226.
https://doi.org/10.3109/15622975.2011.559272 |
| [31] | Ikram, M.A., Bersano, A., Manso-Calderón, R., et al. (2017) Genetics of Vascular Dementia—Review from the ICVD Working Group. BMC Medicine, 15, 48. https://doi.org/10.1186/s12916-017-0813-9 |
| [32] | Yang, T., Sun, Y., Lu, Z., et al. (2017) The Impact of Cerebrovascular Aging on Vascular Cognitive Impairment and Dementia. Ageing Research Reviews, 34, 15-29. https://doi.org/10.1016/j.arr.2016.09.007 |
| [33] | Stankovic, N.D., Teodorczyk, M., Ploen, R., et al. (2016) Microglia-Blood Vessel Interactions: A Double-Edged Sword in Brain Pathologies. Acta Neuropathologica, 131, 347-363. https://doi.org/10.1007/s00401-015-1524-y |
| [34] | Burrows, F., Haley, M.J., Scott, E., et al. (2016) Systemic Inflammation Affects Reperfusion Following Transient Cerebral Ischaemia. Experimental Neurology, 277, 252-260. https://doi.org/10.1016/j.expneurol.2016.01.013 |
| [35] | Sudduth, T.L., Powell, D.K., Smith, C., et al. (2013) Induction of Hyperhomocysteinemia Models Vascular Dementia by Induction of Cerebral Microhemorrhages and Neuroinflammation. Journal of Cerebral Blood Flow & Metabolism, 33, 708-715. https://doi.org/10.1038/jcbfm.2013.1 |
| [36] | Doyle, K.P., Quach, L.N., Solé, M., et al. (2015) B-lymphocyte-Mediated Delayed Cognitive Impairment Following Stroke. Journal of Neuroscience, 35, 2133-2145. https://doi.org/10.1523/JNEUROSCI.4098-14.2015 |
| [37] | Faraco, G., Sugiyama, Y., Lane, D., et al. (2016) Perivascular Macrophages Mediate the Neurovascular and Cognitive Dysfunction Associated with Hypertension. Journal of Clinical Investigation, 126, 4674-4689.
https://doi.org/10.1172/JCI86950 |
| [38] | Montagne, A., Barnes, S.R., Sweeney, M.D., et al. (2015) Blood-Brain Barrier Breakdown in the Aging Human Hippocampus. Neuron, 85, 296-302. https://doi.org/10.1016/j.neuron.2014.12.032 |
| [39] | Tarantini, S., Tran, C.H.T., Gordon, G.R., et al. (2017) Impaired Neurovascular Coupling in Aging and Alzheimer’s Disease: Contribution of Astrocyte Dysfunction and Endothelial Impairment to Cognitive Decline. Experimental Gerontology, 94, 52-58. https://doi.org/10.1016/j.exger.2016.11.004 |
| [40] | Michaud, M., Balardy, L., Moulis, G., et al. (2013) Proinflammatory Cytokines, Aging, and Age-Related Diseases. Journal of the American Medical Directors Association, 14, 877-882. https://doi.org/10.1016/j.jamda.2013.05.009 |
| [41] | 周映彤, 黎罗明, 冯欣, 等. 睡眠呼吸暂停综合征与血管性认知功能障碍的相关性研究[J]. 中国医药科学, 2015, 5(10): 151-152, 170. |
| [42] | Tsai, S., Lu, M.K., San, S., et al. (2020) The Neurologic Manifestations of Coronavirus Disease 2019 Pandemic: A Systemic Review. Frontiers in Neurology, 11, 498-502. https://doi.org/10.3389/fneur.2020.00498 |
| [43] | 吉维忠, 吴世政. 高原低氧环境诱导认知功能损害研究现况[J]. 中国高原医学与生物学杂志, 2019, 40(3): 189-193. |
| [44] | Lefferts, W.K., DeBlois, J.P., White, C.N., et al. (2019) Changes in Cognitive Function and Latent Processes of Decision-Making during Incremental Ascent to High Altitude. Physiology & Behavior, 201, 139-145.
https://doi.org/10.1016/j.physbeh.2019.01.002 |
| [45] | Corina, V., Bianca, B., Doini？a, C., et al. (2013) Neuroprotective Effect of Melatonin in Experimentally Induced Hypobaric Hypoxia. Romanian Journal of Morphology and Embryology, 54, 1097-1106. |
| [46] | Heim, C., Zhang, J., Lan, J., et al. (2000) Cerebral Oligaemia Episode Triggers Free Radical Formation and Late Cognitive Deficiencies. European Journal of Neuroscience, 12, 715-725.
https://doi.org/10.1046/j.1460-9568.2000.00916.x |
| [47] | Barhwal, K., Hota, S.K., Jain, V., et al. (2009) Acetyl-l-carnitine (ALCAR) Prevents Hypobaric Hypoxia-Induced Spatial Memory Impairment through Extracellular Related Kinase-Mediated Nuclear Factor Erythroid 2-Related Factor 2 Phosphorylation. Neuroscience, 161, 501-514. https://doi.org/10.1016/j.neuroscience.2009.02.086 |
| [48] | Kandikattu, H.K., Deep, S.N., Razack, S., et al. (2017) Hypoxia Induced Cognitive Impairment Modulating Activity of Cyperus Rotundus. Physiology & Behavior, 175, 56-65. https://doi.org/10.1016/j.physbeh.2017.03.035 |
| [49] | Chen, X., Zhang, Q., Wang, J., et al. (2017) Cognitive and Neuroimaging Changes in Healthy Immigrants upon Relocation to a High Altitude: A Panel Study. Human Brain Mapping, 38, 3865-3877. https://doi.org/10.1002/hbm.23635 |
| [50] | Brisson, C., Hsieh, Y.T., Kim, D., et al. (2014) Brainstem Neurons Survive the Identical Ischemic Stress That Kills Higher Neurons: Insight to the Persistent Vegetative State. PLoS ONE, 9, e96585.
https://doi.org/10.1371/journal.pone.0096585 |
| [51] | Arvanitakis, Z., Leurgans, S.E., Barnes, L.L., et al. (2011) Microinfarct Pathology, Dementia, and Cognitive Systems. Stroke, 42, 722-727. https://doi.org/10.1161/STROKEAHA.110.595082 |
| [52] | Tsoi, K.K., Chan, J., Hirai, H.W., et al. (2015) Cognitive Tests to Detect Dementia: A Systematic Review and Meta-Analysis. JAMA Internal Medicine, 175, 1450-1458. https://doi.org/10.1001/jamainternmed.2015.2152 |
| [53] | 王拥军. 2016中国血管性认知障碍诊疗指导规范[J]. 心脑血管病防治, 2017, 17(1): 3-6. |
| [54] | Gong, L., Gu, Y., Yu, Q., et al. (2020) Prognostic Factors for Cognitive Recovery beyond Early Poststroke Cognitive Impairment (PSCI): A Prospective Cohort Study of Spontaneous Intracerebral Hemorrhage. Frontiers in Neurology, 11, 278. https://doi.org/10.3389/fneur.2020.00278 |
| [55] | Zlokovic, B.V., Gottesman, R.F., Bernstein, K.E., et al. (2020) Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop. Alzheimer’s & Dementia Journal, 16, 1714-1733.
https://doi.org/10.1002/alz.12157 |
| [56] | Rockwood, K., Mitnitski, A., Black, S.E., et al. (2013) Cognitive Change in Donepezil Treated Patients with Vascular or Mixed Dementia. Canadian Journal of Neurological Sciences, 40, 564-571.
https://doi.org/10.1017/S0317167100014670 |
| [57] | Kavirajan, H. and Schneider, L.S. (2007) Efficacy and Adverse Effects of Cholinesterase Inhibitors and Memantine in Vascular Dementia: A Meta-Analysis of Randomised Controlled Trials. The Lancet Neurology, 6, 782-792.
https://doi.org/10.1016/S1474-4422(07)70195-3 |
| [58] | 张楠. 血管性痴呆的治疗进展[J]. 中国全科医学, 2013, 16(42): 4239-4241. |
| [59] | Alzheimer’s Association (2019) Alzheimer’s Disease Facts and Figures. Alzheimer’s & Dementia Journal, 2019, 321-387. https://doi.org/10.1016/S1474-4422(07)70195-3 |
