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光生物调节在阿尔茨海默病治疗中的研究进展
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Abstract:
阿尔茨海默病是一种与年龄相关、发病隐匿、进行性痴呆的疾病。远红/近红外光(FR/NIR)是波长范围在630 nm~1000 nm之间的电磁波，可由低能量激光或发光二极管(LED)产生，该范围内的光线在体内及体外可以产生光生物调节(Photobiomodulation, PBM)效应，近二十年来，PBM作为一种新的治疗方式，在神经病学和精神病学领域得到了广泛的应用。本文回顾了已发表的在动物和临床实验，总结了现阶段对AD发病机制的了解，并对其试验参数、安全性等进行了综述。
Alzheimer’s disease is an age-related, insidious and progressive dementia. Far red/near infrared light (FR/NIR) is an electromagnetic wave with the wavelength range of 630 nm~1000 nm, which can be generated by low-energy laser or light-emitting diode (LED). The light in this range can produce photobiomodulation effect in vivo and in vitro, in recent 20 years, as a new treatment, PBM has been widely used in neurology and psychiatry. This paper reviews the published animal and clinical trials, summarizes the current understanding of the pathogenesis of AD, and reviews its experimental parameters and safety.
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