89,590例综合医院住院患者梅毒血清学检测结果分析
Analysis of Syphilis Serological Test Results of 89,590 Inpatients in General Hospital

目的：对综合医院住院患者梅毒血清学检测结果进行分析，了解目前梅毒感染者流行病学特征。方法：用化学发光酶免疫检测法(CLEIA)进行梅毒螺旋体抗体筛查，阳性者行梅毒螺旋体明胶凝集试验(TPPA)及快速血浆反应素实验(RPR)。对青岛大学附属医院西海岸院区在2019年1月至2020年12月89,590例住院患者进行梅毒血清学检测结果分析。结果：89,590例患者中，TP抗体阳性者1216例，阳性率为1.36%，其中男性阳性例数为679例，阳性率为1.51%；女性阳性例数为537例，阳性率为1.20%，差异具有统计学意义(P < 0.01)。TP抗体阳性率在2019年和2020年分别为1.32%和1.40%，差异无统计学意义(P = 0.32)。在不同年龄段，其中≥80岁组检测阳性率最高，达2.34%。科室分布中，TP抗体阳性者主要集中于妇产科、心内科、普外科、骨科，普外科最高，构成比达14.72%。TP抗体阳性患者中，TPPA阳性率为68.50%，TPPA及RPR双阳性患者占比为24.92%。各年龄段RPR滴度1:1~1:8分别为0.40%，24.82%，19.76%，27.24%，32.69%，RPR滴度 > 1:8分别为0.20%，8.51%，8.38%，16.94%，17.31%，明显小于相应年龄段1:1~1:8滴度百分比。结论：梅毒血清学特点在不同年龄段、不同性别、不同科室中不尽相同。隐性梅毒在住院患者中分布广泛，对住院患者进行早期梅毒筛查非常有必要。
Objective: To analyze the test results of syphilis in inpatients in general hospital, and to understand the epidemiological characteristics of syphilis infected patients. Method: Treponema pallidum antibody was screened by chemiluminescent enzyme immunoassay (CLEIA). The positive patients were tested by Treponema pallidum gelatin agglutination test (TPPA) and rapid plasma reagin test (RPR). The syphilis serological test results of 89,590 inpatients in the West Coast Hospital of the Affiliated Hospital of Qingdao University from January 2019 to December 2020 were analyzed. Result: Among 89,590 patients, 1216 were TP antibody positive, the positive rate was 1.36%, of which 679 were male, the positive rate was 1.51%; the number of female positive cases was 537, and the positive rate was 1.20%. The difference was statistically significant (P < 0.01). The positive rates of TP antibody in 2019 and 2020 were 1.32% and 1.40% respectively, and the difference was not statistically significant (P = 0.32). In different age groups, the positive rate of ≥80 years old group was the highest, up to 2.34%. In the distribution of departments, TP antibody positive patients are mainly concentrated in gynecology and obstetrics, cardiology, general surgery and orthopedics. General surgery is the highest, with a composition ratio of 14.72%. Among TP antibody positive patients, the positive rate of TPPA was 68.50%, and the proportion of TPPA and RPR double positive patients was 24.92%. The RPR titers of 1:1~1:8 in each age group were 0.40%, 24.82%, 19.76%, 27.24% and 32.69% respectively. The RPR titers of more than 1:8 were 0.20%, 8.51%, 8.38%, 16.94% and 17.31% respectively, which was significantly less than the titer percentage of 1:1~1:8 in the corresponding age group. Conclusion: The serological characteristics of syphilis are different in different age groups, different genders and different departments. Latent syphilis is widely