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人乳头瘤病毒单一、多重亚型感染与阴道上皮内瘤变的关系
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Abstract:
阴道上皮内瘤变(Vaginal intraepithelial neoplasia, VAIN)作为阴道上皮不典型增生及原位癌的一组病变，是阴道上皮癌的癌前病变的总称。与宫颈上皮内瘤变(Cervical intraepithelial neoplasia, CIN)相似，人乳头瘤病毒(HPV)感染是VAIN发生的主要致病因素。目前关于HPV亚型感染与VAIN之间相关性报道仍然较少。本文对HPV单一亚型、多重亚型感染及其在VAIN发生发展的研究进展方面进行综述，以期在临床治疗中达到对VAIN的早期诊断，降低阴道上皮的恶性发展率，提高存活率。
Vaginal intraepithelial neoplasia (VAIN), as a group of lesions of vaginal epithelial atypical hyperplasia and carcinoma in situ, is the general name of precancerous lesions of vaginal epithelial carcinoma. Similar to cervical intraepithelial neoplasia (CIN), human papillomavirus (HPV) infection is the main pathogenic factor of VAIN. At present, there are still few reports about the correlation between HPV subtype infection and VAIN. This article reviews the research progress of HPV single subtype and multiple subtype infection and its occurrence and development in VAIN, in order to achieve the early diagnosis of VAIN in clinical treatment, reduce the malignant development rate of vaginal epithelium and improve the survival rate.
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