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自噬介导下的胃癌化疗耐药性
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Abstract:
胃癌是消化系统中常见恶性肿瘤之一，铂类药物是标准的一线治疗，在治疗过程中胃癌细胞会以一种适应性方式生存产生多药耐药性细胞株，即化疗耐药性，疾病进展。自噬作为一种高度保守的体内平衡途径，主要受长链非编码RNA (LncRNA)、miRNA等不同因子的调控，在胃癌的化学抗性中起着双重作用。因此，近年来小分子抑制剂或激活剂作为靶向自噬过程中的关键调控点为胃癌的治疗提供了新的策略。在这篇综述中，我们提供了系统总结，着重于自噬与胃癌化疗抗药性之间的关系。我们全面讨论了长链非编码LncRNA和miRNA等不同因子在自噬途径和胃癌化学耐药性调控中的作用和分子机制。
Objective: Gastric cancer is one of the common malignant tumors in the digestive system. Platinum drugs are the standard first-line treatment. During the treatment, gastric cancer cells will survive in an adaptive way to produce multidrug resistant cell lines, that is, chemotherapy resistance and disease progression. As a highly conserved homeostasis pathway, autophagy is mainly regulated by different factors such as long non-coding RNA (LncRNA) and miRNA, and plays a dual role in the chemoresistance of gastric cancer. In recent years, small molecule inhibitors or activators have provided new strategies for the treatment of gastric cancer as key regulatory points in the process of targeted autophagy. In this review, we provide a systematic summary focusing on the relationship between autophagy and chemotherapy resistance in gastric cancer. We comprehensively discussed the roles and molecular mechanisms of different factors such as long-chain non-coding LncRNA and miRNA in the autophagy pathway and the regulation of gastric cancer chemoresistance.
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