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术前炎症指标在直肠癌预后中的研究进展
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Abstract:
直肠癌是全球癌症相关死亡的三大原因之一,其复发和转移是癌症患者死亡和不良预后的主要原因。大量研究报道,系统性免疫炎症指数、中性粒细–淋巴细胞比率、血小板–淋巴细胞比率和淋巴细胞–单核细胞比率等各项炎症指标与直肠癌的进展和预后密切相关。本文重点总结了近年来各项炎症指标在直肠癌预后中的研究。
Colorectal cancer is one of the top three causes of cancer-related death worldwide, and its recurrence and metastasis are the major causes of death and poor prognosis in cancer patients. A large number of studies have reported that systemic immune inflammation index, neutral granular fine-to-lymphocyte ratio, platelet-to-lymphocyte ratio and lymphocyte-to-monocyte ratio are closely related to the progression and prognosis of rectal cancer. In this paper, the effect of inflammatory indexes on the prognosis of rectal cancer was summarized.
[1] | 中华人民共和国国家卫生健康委员会. 中国结直肠癌诊疗规范(2020年版) [J]. 中华外科杂志, 2020(8): 561-585. |
[2] | 牛晋卫. 结直肠肿瘤: 预防和早期筛查很重要[J]. 中老年保健, 2020(4): 20-21. |
[3] | Gurram, M.K. and Pulivarthi, S. (2014) Effectiveness of D-Dimer as a Screening Test for Venous Thromboembolism: An Update. North American Journal of Medicine and Science, 6, 491-499. https://doi.org/10.4103/1947-2714.143278 |
[4] | Yatabe, S., Eto, K., Haruki, K., Shiba, H., Kosuge, M., Ohkuma, M., et al. (2020) Signification of Systemic Immune-Inflammation Index for Prediction of Prognosis after Resecting in Patients with Colorectal Cancer. International Journal of Colorectal Disease, 35, 1549-1555. https://doi.org/10.1007/s00384-020-03615-w |
[5] | Hu, B., Yang, X., Xu, Y., Sun Y.-F., Sun, C., Guo, W., et al. (2014) Systemic Immune-Inflammation Index Predicts Prognosis of Patients after Curative Resection for Hepatocellular Carcinoma. Clinical Cancer Research, 20, 6212-6222.
https://doi.org/10.1158/1078-0432.CCR-14-0442 |
[6] | Guo, W., Cai, S., Zhang, F., Shao, F., Zhang, G., Zhou, Y., et al. (2019) Systemic Immune-Inflammation Index (SII) Is Useful to Predict Survival Outcomes in Patients with Surgically Resected Non-Small Cell Lung Cancer. Thoracic Cancer, 10, 761-768. https://doi.org/10.1111/1759-7714.12995 |
[7] | Bartl, T., Bekos, C., Postl, M., Alexander, R., Polterauer, S., Stefanie, A., et al. (2021) The Systemic Immune-Inflammation Index (SII) Is an Independent Prognostic Parameter of Survival in Patients with Invasive Vulvar Cancer. Journal of Gynecologic Oncology, 32, e1. https://doi.org/10.3802/jgo.2021.32.e1 |
[8] | 武红梅, 陈创. CEA、CA199、CA125的检测在结直肠癌患者中的诊断价值[J]. 海南医学院学报, 2014, 20(5): 643-645+649. |
[9] | Hanahan, D. and Weinberg, R. (2011) Hallmarks of Cancer: The Next Generation. Cell, 144, 646-674.
https://doi.org/10.1016/j.cell.2011.02.013 |
[10] | 王倩, 苗亚静, 文明. 慢性炎症与肿瘤关系的研究进展[J]. 继续医学教育, 2015(9): 79-81. |
[11] | Stotz, M., Gerger, A., Eisner, F., Szkandera, J., Loibner, H., Ress, A.L., et al. (2013) Increased Neutrophil-Lymphocyte Ratio Is a Poor Prognostic Factor in Patients with Primary Operable and Inoperable Pancreatic Cancer. British Journal of Cancer, 109, 416-421. https://doi.org/10.1038/bjc.2013.332 |
[12] | Cools-Lartigue, J., Spicer, J., Mcdonald, B., Gowing, S., Chow, S., Giannias, B., et al. (2013) Neutrophil Extracellular Traps Sequester Circulating Tumor Cells and Promote Metastasis. Journal of Clinical Investigation, 123, 3446-3458.
https://doi.org/10.1172/JCI67484 |
[13] | Labelle, M., Begum, S. and Hynes, R. (2011) Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis. Cancer Cell, 20, 576-590.
https://doi.org/10.1016/j.ccr.2011.09.009 |
[14] | Schumacher, D., Strilic, B., Sivaraj, K., Wettschureck, N. and Offermanns, S. (2013) Platelet-Derived Nucleotides Promote Tumor-Cell Transendothelial Migration and Metastasis via P2Y2 Receptor. Cancer Cell, 24, 130-137.
https://doi.org/10.1016/j.ccr.2013.05.008 |
[15] | Olingy, C., Dinh, H. and Hedrick, C. (2019) Monocyte Heterogeneity and Functions in Cancer. Journal of Leukocyte Biology, 106, 309-322. https://doi.org/10.1002/JLB.4RI0818-311R |
[16] | 张立志, 刘平, 吉慧军, 李守春, 张志文. 全身炎症反应指数对胶质瘤患者临床预后影响及与IDH1突变的关系[J]. 实用肿瘤学杂志, 2018, 32(1): 25-32. |
[17] | 孔梁好, 张先舟, 庄昊, 韩风. 系统免疫炎症指数与胆囊癌患者预后的相关性[J]. 中华肝胆外科杂志, 2019, 25(12): 894-898. |
[18] | Murthy, P., Zenati, M.S., Al Abbas, A.I., Rieser, C.J., Bahary, N., Lotze, M.T., et al. (2020) Prognostic Value of the Systemic Immune-Inflammation Index (SII) After Neoadjuvant Therapy for Patients with Resected Pancreatic Cancer. Annals of Surgical Oncology, 27, 898-906. https://doi.org/10.1245/s10434-019-08094-0 |
[19] | Zhang, Y., Lin, S., Yang, X., Wang, R. and Luo, L. (2019) Prognostic Value of Pretreatment Systemic Immune-Inflammation Index in Patients with Gastrointestinal Cancers. Journal of Cellular Physiology, 234, 5555-5563.
https://doi.org/10.1002/jcp.27373 |
[20] | 何朝滨, 林小军. 中性粒细胞/淋巴细胞比值血小板/淋巴细胞比值与TACE治疗肝癌患者预后的相关性[J]. 中国肿瘤临床, 2017, 44(6): 283-288. |
[21] | 张文琪, 郝权. 术前外周血NLR对上皮性卵巢癌患者预后的影响[J]. 中国肿瘤临床, 2014(10): 634-638. |
[22] | Jaiswal, D., Mantha, S., Wong, L., Seija, L. and Munoz, Y. (2017) A Retrospective Analysis on the Impact of Preoperative Neutrophil to Lymphocyte Ratio in Stage II Colon Cancer. Journal of Clinical Oncology, 35, 794-794.
https://doi.org/10.1200/JCO.2017.35.4_suppl.794 |
[23] | Wu, L., Saxena, S. and Singh, R.K. (2020) Neutrophils in the Tumor Microenvironment. In: Birbrair, A., Ed., Tumor Microenvironment, Vol. 1224, Springer, Cham, 1-20. https://doi.org/10.1007/978-3-030-35723-8_1 |
[24] | Wu, Y., Jiang, M., Qin, Y., Lin, F. and Lai, M. (2018) Single and Combined Use of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Carcinoembryonic Antigen in Diagnosing Gastric Cancer. Clinica Chimica Acta, 481, 20-24. https://doi.org/10.1016/j.cca.2018.02.027 |
[25] | Lee, H., Choi, H., Ha, S., Lee, K.-T. and Kwon, Y.-G. (2013) Recruitment of Monocytes/Macrophages in Different Tumor Microenvironments. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1835, 170-179.
https://doi.org/10.1016/j.bbcan.2012.12.007 |
[26] | Abe, S., Kawai, K., Nozawa, H., Hata, K., Kiyomatsu, T., Morikawa, T., et al. (2018) LMR Predicts Outcome in Patients after Preoperative Chemoradiotherapy for Stage II-III Rectal Cancer. Journal of Surgical Research, 222, 122-131.
https://doi.org/10.1016/j.jss.2017.09.053 |