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艾滋病病毒感染与肠道菌群之间的相互作用关系研究进展
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Abstract:
HIV的感染与肠道屏障被破坏和微生物产物的移位密切相关。因HIV感染而引起的肠道菌群失调愈发受到关注。目前研究主要致力于理解HIV感染后肠道微生态的变化情况，即肠道微生物组的构成以及它们是如何与黏膜免疫细胞相互作用来引起全身炎症的。本文主要综述了目前研究HIV感染与微生态及其失调的关系和失调与HIV发病机理的内在联系，以便更好地理解微生态相关的免疫激活和驱动全身炎症反应的机制，从而制定不同的治疗方案来改善肠道菌群失调，进而提高HIV感染者的整体健康。
HIV infection is closely associated with the disruption of the intestinal barrier and the displacement of microbial products. Intestinal microflora dysregulation caused by HIV infection are gaining attention. The current research is focused on understanding the changes in gut microbiome following HIV infection including the composition of the gut microbiome and how they interact with mucosal immune cells to cause systemic inflammation. This paper reviews the relevance of the present study of the relationship between HIV infection and intestinal microflora dysregulation and the intrinsic link between dysregulation and the pathogenesis of AIDS. The data will gain a better understanding the mechanisms of the microecology-related immune activation and drive systemic inflammatory response. Thus formulate differences treatment options to improve intestinal microbiosis, and then improve the overall health of people infected with HIV.
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