Introduction: Unilateral nasal mass can be benign or malignant. Very rarely we will find benign salivary gland tumor in nasal cavity. Pleomorphic adenoma is still the most common pathological variety either in major or minor salivary gland tumors. In the nasal cavity, even though most of the accessory salivary glands are present in the lateral wall of nose, nasal septum remains the most common site of origin. Case Report: A 40-year-old female presented with right-sided nasal obstruction and epistaxis. CT scan of Nose and Paranasal sinuses found a lesion involving the anterior third of the right nasal cavity. The patient underwent complete surgical resection of the tumor via an endonasal approach. Histological examination found a mixed cellular component (epithelial and myoepithelial) and mesenchymatous tissue with chondromyxoid stroma, enabling diagnosis of a typical pleomorphic adenoma. Conclusion: Pleomorphic adenoma is the most common salivary gland tumor but rare to find in the nasal cavity with only few cases reported in the literature. Although benign, the risk of local recurrence, malignant transformation and metastasis requires close long-term follow-up.
References
[1]
Rudralingam, M., Jones, K. and Woolford, T.J. (2002) The Unilateral Opaque Maxillary Sinus on Computed Tomography. British Journal of Oral and Maxillofacial Surgery, 40, 504-507. https://doi.org/10.1016/S0266-4356(02)00225-5
[2]
Habesoglu, T.E., Habesoglu, M., Surmeli, M., Uresin, T. and Egeli, E. (2010) Unilateral Sinonasal Symptoms. Journal of Craniofacial Surgery, 21, 2019-2022. https://doi.org/10.1097/SCS.0b013e3181f5389a
[3]
Valencia, M.P. and Castillo, M. (2008) Congenital and Acquired Lesions of the Nasal Septum: A Practical Guide for Differential Diagnosis. RadioGraphics, 28, 205-223. https://doi.org/10.1148/rg.281075049
[4]
Jassar, P., Stafford, N. and Macdonald, A. (1999) Pleomorphic adenoma of the Nasal Septum. The Journal of Laryngology & Otology, 113, 483-485. https://doi.org/10.1017/S0022215100144299
[5]
Sciandra, D., Dispenza, F., Porcasi, R., et al. (2008) Pleomorphic adenoma of the Lateral Nasal Wall: Case Report. ACTA Otorhinolaryngologica Italica, 28, 150-153.
[6]
Malinvaud, D., Couloigner, V., Badoual, C., Halimi, P., et al. (2006) Pleomorphic adenoma of the Nasal Septum and Its Relationship with Epstein-Barr Virus. Auris Nasus Larynx, 33, 417-421. https://doi.org/10.1016/j.anl.2006.05.006
[7]
Compango, J. and Wong, R.T. (1977) lntranasal Mixed Turnouts (Pleomorphic adenoma): A Clinicopathologic Study of 40 Cases. American Journal of Clinical Pathology, 68, 213-218. https://doi.org/10.1093/ajcp/68.2.213
[8]
Ersner, M.S. and Saltzman, M. (1944) A Mixed Tumor of the Nasal Septum. Report of a Case. The Laryngoscope, 54, 287-296. https://doi.org/10.1288/00005537-194406000-00004
[9]
Yazibene, Y., Ait-Mesbah, N., Kalafate, S., Yahi-Ait Mesbah, N., Abdennebi, A., Bouzid, H., et al. (2011) Degenerative Pleomorphic adenoma of the Nasal Cavity. European Annals of Otorhinolaryngology, Head and Neck Diseases, 128, 37-40. https://doi.org/10.1016/j.anorl.2010.09.006
[10]
Oztürk, E., Sağlam, O., Sönmez, G., Cüce, F. and Haholu, A. (2008) CT and MRI of an Unusual Intranasal Mass: Pleomorphic adenoma. Diagnostic and Interventional Radiology, 14, 186-188.
[11]
Batsakis, J.G. (1984) Tumors of the Head and Neck. 2nd Edition, Williams and Wilkin, Baltimore, 76-99.
[12]
Kahler, D. (1929) Handush der Hals. Nasen Ohrenheilkunde, 5, 202.
[13]
Kandoğan, T., Dalğıç, A., Gültekin, G., Ulusoy, S. and Selek, E. (2015) Pleomorphic adenoma of the Nasal Cavity. Journal of Academic Research in Medicine, 5, 25-27. https://doi.org/10.5152/jarem.2015.523
[14]
Stevenson, H.N. (1932) Mixed Tumor of the Septum. Annals of Otology, Rhinology & Laryngology, 41, 563-570. https://doi.org/10.1177/000348943204100222
[15]
Evans, R.W. and Cruikshank, A.H. (1970) Epithelial Tumors of the Salivary Glands. In: Major Problems in Pathology (Vol. 1), WB Saunders, Philadelphia, 281-295.
[16]
Wakami, S., Muraoka, M. and Nakai, Y. (1996) Two Cases of Pleomorphic adenoma of the Nasal Cavity. Nippon Jibiinkoka Gakkai Kaiho, 99, 38-45.
[17]
Acevedo, J.L., Nolan, J., Markwell, J.K. and Thompson, D. (2010) Pleomorphic adenoma of the Nasal Cavity: A Case Report. Ear, Nose & Throat Journal, 89, 224-226. https://doi.org/10.1177/014556131008900508
[18]
Motoori, K., Takano, H., Nakano, K., Yamamoto, S., Ueda, T. and Ikeda, M. (2000) Pleomorphic adenoma of the Nasal Septum: MR Features. American Journal of Neuroradiology, 21, 1948-1950.
[19]
Haberman, R.S. and Stanley, D.E. (1989) Pleomorphic adenoma of the Nasal Septum. Otolaryngologic—Head and Neck Surgery, 100, 610-612. https://doi.org/10.1177/019459988910000616
[20]
Hirai, S., Matsumoto, T. and Suda, K. (2002) Pleomorphic adenoma in Nasal Cavity: Immunohistochemical Study of Three Cases. Auris Nasus Larynx, 29, 291-295. https://doi.org/10.1016/S0385-8146(01)00150-X
[21]
Suzuki, K. Moribe, K. and Baba, S. (1990) A Rare Case of Pleomorphic adenoma of the Lateral Wall of the Nasal Cavity with Special Reference of Statistical Observation of Pleomorphic adenoma of the Nasal Cavity in Japan. The Oto-Rhino-Laryn-gological Society of Japan, 93, 740-745.
[22]
Avishay, G., Yudith, B. and Milo, F. (1997) Pleomorphic Nasoseptal Adenoma. Journal of Otolaryngology, 26, 399-401.
[23]
Sengul, I. and Sengul, D. (2011) Pleomorphic adenoma of the Lower Lip: A Review. North American Journal of Medicine and Science, 3, 536-539.
[24]
Röijer, E., Nordkvist, A., Ström, A.K., et al. (2002) Translocation, Deletion/Ampli-fication, and Expression of HMGIC and MDM2 in a Carcinoma ex Pleomorphic adenoma. The American Journal of Pathology, 160, 433-440. https://doi.org/10.1016/S0002-9440(10)64862-6
[25]
Wermuth, M.J., Mann, C.H. and Odere, F. (1988) Metastasizing Pleomorphic adenoma Arising in the Soft Palate. Otolaryngologic—Head and Neck Surgery, 99, 505-508. https://doi.org/10.1177/019459988809900509