|
|
5-羟色胺1受体、5-羟色胺转运体与酒精依赖综合征关联研究进展
|
Abstract:
酒精依赖综合征指反复大量饮酒引起的特殊心理状态，表现为对酒精的渴求和经常需要饮酒的强迫性体验，是饮酒导致酒精的精神和躯体依赖。有害使用酒精已成为世界范围内致病、致残和致死的五大风险因素之一，给社会造成严重的经济负担。研究表明酒精依赖综合征与遗传因素相关联。本文综述了遗传基因多态性与酒精依赖综合征患者关联的研究进展，分析了两者间形成关联的可能机制，提出了目前研究存在的局限性以及未来的研究方向，为酒精依赖综合征的预防控制提供科学依据。
Alcohol dependence syndrome refers to a special psychological state caused by repeated heavy drinking, manifested as a thirst for alcohol and a compulsive experience of frequent need to drink, which is the mental and physical dependence of alcohol caused by drinking. Harmful use of alcohol has become one of the five major risk factors for disease, disability, and death worldwide, causing a serious economic burden on society. Studies have shown that alcohol dependence syndrome is associated with genetic factors. This article reviews the research progress on the association between genetic polymorphisms and alcohol dependence syndrome patients, analyzes the possible mechanism of the association between the two, and proposes the limitations of current research and future research direction, providing scientific basis for the prevention and control of alcohol dependence syndrome.
| [1] | World Health Organization (2018) Global Status Report on Alcohol and Health. World Health Organization, Geneva. |
| [2] | Schuckit, M.A. (2009) Alcohol-Use Disorders. The Lancet (London, England), 373, 492-501.
https://doi.org/10.1016/S0140-6736(09)60009-X |
| [3] | (2009) Alcohol Misuse Needs a Global Response. The Lancet (London, England), 373, 433.
https://doi.org/10.1016/S0140-6736(09)60146-X |
| [4] | Asan, E. (1998) The Catecholaminergic Innervation of the Rat Amygdala. Advances in Anatomy, Embryology, and Cell Biology, Vol. 142, Springer, Berlin, 1-118. https://doi.org/10.1007/978-3-642-72085-7_1 |
| [5] | Hornung, J.P. (2003) The Human Raphe Nuclei and the Serotonergic System. Journal of Chemical Neuroanatomy, 26, 331-343. https://doi.org/10.1126/science.1078197 |
| [6] | Rutz, S., Riegert, C., Rothmaier, A.K., et al. (2006) Presynaptic Serotonergic Modulation of 5-HT and Acetylcholine Release in the Hippocampus and the Cortex of 5-HT1B-Receptor Knockout Mice. Brain Research Bulletin, 70, 81-93.
https://doi.org/10.1016/j.brainresbull.2006.04.004 |
| [7] | Walther, D.J., Peter, J.U., Bashammakh, S., et al. (2003) Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform. Science, 299, 76. https://doi.org/10.1126/science.1078197 |
| [8] | Leenders, A.G. and Sheng, Z.H. (2005) Modulation of Neurotransmitter Release by the Second Messenger-Activated Protein Kinases: Implications for Presynaptic Plasticity. Pharmacology & Therapeutics, 105, 69-84.
https://doi.org/10.1016/j.pharmthera.2004.10.012 |
| [9] | Müller, D., Grevet, E.H., Panzenhagen, A.C., et al. (2017) Evidence of Sexual Dimorphism of HTR1B Gene on Major Adult ADHD Comorbidities. Journal of Psychiatric Research, 95, 269-275.
https://doi.org/10.1016/j.jpsychires.2017.09.011 |
| [10] | Contini, V., Bertuzzi, G.P., Polina, E.R., et al. (2012) A Haplotype Analysis Is Consistent with the Role of Functional HTR1B Variants in Alcohol Dependence. Drug and Alcohol Dependence, 122, 100-104.
https://doi.org/10.1016/j.drugalcdep.2011.09.020 |
| [11] | Sun, H.F.S., Chang, Y.T., Fann, S.J., et al. (2002) Association Study of Novel Human Serotonin 5-HT(1B) Polymorphisms with Alcohol Dependence in Taiwanese Han. Biological Psychiatry, 51, 896-901.
https://doi.org/10.1016/S0006-3223(01)01366-X |
| [12] | Lee, S.Y., Lin, W.W., Huang, S.Y., et al. (2009) The Relationship between Serotonin Receptor 1B Polymorphisms A-161T and Alcohol Dependence. Alcoholism: Clinical and Experimental Research, 33, 1589-1595.
https://doi.org/10.1111/j.1530-0277.2009.00990.x |
| [13] | 李培凯. 5-HT1B受体基因G861C、A-161T位点多态性与基诺族酒依赖相关性研究[D]: [硕士学位论文]. 昆明: 昆明医学院, 2007. |
| [14] | 曹金霞. 酒依赖与5-羟色胺相关基因多态性的关联研究[D]: [博士学位论文]. 哈尔滨: 哈尔滨医科大学, 2010. |
| [15] | Wang, S., Zhang, K., Xu, Y., et al. (2009) An Association Study of the Serotonin Transporter and Receptor Genes with the Suicidal Ideation of Major Depression in a Chinese Han Population. Psychiatry Research, 170, 204-207.
https://doi.org/10.1016/j.psychres.2008.12.006 |
| [16] | Duan, J., Sanders, A.R., Molen, J.E., et al. (2003) Polymorphisms in the 5’-Untranslated Region of the Human Serotonin Receptor 1B (HTR1B) Gene Affect Gene Expression. Molecular Psychiatry, 8, 901-910.
https://doi.org/10.1038/sj.mp.4001403 |
| [17] | Bevilacqua, L. and Goldman, D. (2011) Genetics of Emotion. Trends in Cognitive Sciences, 15, 401-408.
https://doi.org/10.1016/j.tics.2011.07.009 |
| [18] | Saier, M.H. (1999) A Functional-Phylogenetic System for the Classification of Transport Proteins. Journal of cellular biochemistry. Supplement, 32-33, 84-94.
https://doi.org/10.1002/(SICI)1097-4644(1999)75:32+<84::AID-JCB11>3.0.CO;2-M |
| [19] | Qian, Y., Melikian, H., Rye, D., et al. (1995) Identification and Characterization of Antidepressant-Sensitive Serotonin Transporter Proteins Using Site-Specific Antibodies. Journal of Neuroscience, 15, 1261-1274.
https://doi.org/10.1523/JNEUROSCI.15-02-01261.1995 |
| [20] | Blakely, R.D., De Felice, L.J. and Hartzell, H.C. (1994) Molecular Physiology of Norepinephrine and Serotonin Transporters. The Journal of Experimental Biology, 196, 263-281. https://doi.org/10.1242/jeb.196.1.263 |
| [21] | Henry, L.K., Adkins, E.M., Han, Q., et al. (2003) Serotonin and Cocaine-Sensitive Inactivation of Human Serotonin Transporters by Methanethiosulfonates Targeted to Transmembrane Domain I. The Journal of Biological Chemistry, 278, 37052-37063. https://doi.org/10.1074/jbc.M305514200 |
| [22] | Babu, D.K., Diaz, A., Samikkannu, T., et al. (2009) Upregulation of Serotonin Transporter by Alcohol in Human Dendritic Cells: Possible Implication in Neuroimmune Deregulation. Alcoholism: Clinical and Experimental Research, 33, 1731-1738. https://doi.org/10.1111/j.1530-0277.2009.01010.x |
| [23] | Heinz, A., Ragan, P., Jones, D.W., et al. (1998) Reduced Central Serotonin Transporters in Alcoholism. The American Journal of Psychiatry, 155, 1544-1549. https://doi.org/10.1176/ajp.155.11.1544 |
| [24] | Thompson, M.D. and Kenna, G.A. (2016) Variation in the Serotonin Transporter Gene and Alcoholism: Risk and Response to Pharmacotherapy. Alcohol and Alcoholism, 51, 164-171. https://doi.org/10.1093/alcalc/agv090 |
| [25] | Praschak-Rieder, N., Kennedy, J., Wilson, A.A., et al. (2007) Novel 5-HTTLPR Allele Associates with Higher Serotonin Transporter Binding in Putamen: A [(11)C] DASB Positron Emission Tomography Study. Biological Psychiatry, 62, 327-331. https://doi.org/10.1016/j.biopsych.2006.09.022 |
| [26] | 王学静, 钟树荣, 鲍建军, 等. 云南汉族人群5-羟色胺转运体基因启动子区多态性与酒精依赖的相关性[J]. 遗传, 2011, 33(1): 48-53. |
| [27] | Pascale, E., et al. (2015) Alcohol Dependence and Serotonin Transporter Functional Polymorphisms 5-HTTLPR and rs25531 in an Italian Population. Alcohol and Alcoholism, 50, 259-265. https://doi.org/10.1093/alcalc/agv014 |
| [28] | Oo, K.Z., Aung, Y.K., Jenkins, M.A., et al. (2016) Associations of 5HTTLPR Polymorphism with Major Depressive Disorder and Alcohol Dependence: A Systematic Review and Meta-Analysis. The Australian and New Zealand Journal of Psychiatry, 50, 842-857. https://doi.org/10.1177/0004867416637920 |
| [29] | Mchugh, R.K., Hofmann, S.G., Asnaani, A., et al. (2010) The Serotonin Transporter Gene and Risk for Alcohol Dependence: A Meta-Analytic Review. Drug and Alcohol Dependence, 108, 1-6.
https://doi.org/10.1016/j.drugalcdep.2009.11.017 |
