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新冠状病毒中SARS-CoV-2/Human/CHN/Bejing_BJ0613-12-HJ/2020毒株的分析
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Abstract:
生物信息学分析的方法被广泛用于多个物种的多个基因家族的分析。随着新冠病毒(SARS-CoV-2)的蔓延，导致感染肺炎的人数也越在与日俱增，对于已知的SARS-CoV-2序列的鉴定相继被报道。对于具体的SARS-CoV-2序列的分析可能有助于帮助分析其他新增SARS-CoV-2序列，为新增的新型冠状病毒的传播途径、分子诊断和临床治疗提供基础的信息。本研究选取北京新增的病毒株名为SARS-CoV-2/human/ CHN/Bejing_BJ0613-12-HJ/2020的SARS-CoV-2，采用生物信息学方法对系统发育、蛋白质特征进行分析，并预测了它们的蛋白模型。以期望为抗病毒药物的研发提供有效的依据或提供新的思路。
Bioinformatics analysis methods were used widely in the analysis of multiple gene families in different species. The number of people infected with pneumonia is increasing day by day because of the spread of the COVID-19 (SARS-CoV-2). Fortunately, the analysis of those reported and identified known SARS-CoV-2 sequences may help analyze other newly similar, and provide underlying information for the transmission route, molecular diagnosis, and clinical treatment of the novel coronavirus SARI. In this study, the newly-added virus strain (SARS-CoV-2/human/CHN/Bejing_BJ0613-12-HJ/2020, SARS-CoV-2 in Beijing) was selected and used the bioinformatics method to analyze the phylogeny and protein characteristics. Those protein models were analyzed and predicted for the expectation to provide a basis or new ideas for the development of antiviral drugs.
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