Background:Acute kidney injury (AKI) is a life threatening
condition with still high mortality rate in neonates. Early recognition of the
risk factors and the rapid effective treatment of the contributing conditions
will reduce AKI in the neonatal period. Aim of the Work: To determine association between early
caffeine citrate administration and risk of acute kidney injury in hospitalized
preterm neonates.？Patients and Methods: This study was a prospective study that was conducted at
the NICU of El Galaa Teaching Hospital. This study included 100 preterm
neonates who were born alive from 32 weeks to 35 weeks of gestation. Results: There was highly
statistically significant occurrence of apneaic episode in preterm babies who
don’t receive caffeine citrate and consequently decreased incidence of AKI in
those babies. Conclusion: We concluded that caffeine citrate administration in
preterm babies is associated with reduced incidence of apneaic episode and
consequently reduced risk of AKI.
References
[1]
Ghobrial, E.E., Elhouchi, S.Z., Eltatawy, S.S. and Beshara, L.O. (2018) Risk Factors Associated with Acute Kidney Injury in Newborns. Saudi Journal of Kidney Disease and Transplantation, 29, 81-87. https://doi.org/10.4103/1319-2442.225179
[2]
Biyik, M., Ataseven, H., Biyik, Z., Asil, M., Çifçi, S., Sayin, S., Demir, A. and Tombul, H.Z. (2016) KDIGO (Kidney Disease: Improving Global Outcomes) Criteria as a Predictor of Hospital Mortality in Cirrhotic Patients. The Turkish Journal of Gastroenterology, 27, 173-179. https://doi.org/10.5152/tjg.2016.15467
[3]
Favre, N., Burnier, M. and Kissling, S. (2016) When the Nephrologist Should Be Called in the Emergency Room. Revue Médicale Suisse, 12, 398-403.
[4]
Moledina, D.G. and Perazella, M.A. (2016) PPIs and Kidney Disease: from AIN to CKD. Journal of Nephrology, 29, 611-616.
https://doi.org/10.1007/s40620-016-0309-2
[5]
Meola, M., Nalesso, F., Petrucci, I., Samoni, S. and Ronco, C. (2016) Pathophysiology and Clinical Work-Up of Acute Kidney Injury. Contributions to Nephrology, 188, 1-10. https://doi.org/10.1159/000445460
[6]
Vohr, B. (2013) Long-Term Outcomes of Moderately Preterm, Late Preterm and Early Term Infants. Clinics in Perinatology, 39, 769-776.
https://doi.org/10.1016/j.clp.2013.07.006
[7]
Eichenwald, E.C. and the Committee on Fetus and Newborn (2016) Apnea of Prematurity. Pediatrics, 137, 1-7. https://doi.org/10.1542/peds.2015-3757
[8]
Patel, B.K. and Shah, J.S. (2012) Necrotizing Enterocolitis in Very Low Birth Weight Infants: A Systemic Review. ISRN Gastroenterology, 2012, Article ID: 562594.
https://doi.org/10.5402/2012/562594
[9]
Raina, A., Pandita, A., Harish, R., Yachha, M. and Jamwal, A. (2016) Treating Perinatal Asphyxia with Theophylline at Birth Helps to Reduce the Severity of Renal Dysfunction in Term Neonates. Acta Paediatrica, 105, e448-e451.
https://doi.org/10.1111/apa.13469
[10]
Dobson, N.R., Patel, R.M., Smith, P.B., et al. (2014) Trends in Caffeine Use and Association between Clinical Outcomes and Timing of Therapy in Very Low Birth Weight Infants. The Journal of Pediatrics, 164, 992-998.e3.
https://doi.org/10.1016/j.jpeds.2013.12.025
[11]
Carmody, J.B., Harer, M.W., Denotti, A.R., Swanson, J.R. and Charlton, J.R. (2016) Caffeine Exposure and Risk of Acute Kidney Injury in a Retrospective Cohort of Very Low Birth Weight Neonates. The Journal of Pediatrics, 172, 63-68.e1.
https://doi.org/10.1016/j.jpeds.2016.01.051
[12]
Harer, M.W., Askenazi, D.J., Boohaker, L.J., Carmody, J.B., Griffin, R.L., Guillet, R., Selewski, D.T., Swanson, J.R. and Charlton, J.R. (2018) Association between Early Caffeine Citrate Administration and Risk of Acute Kidney Injury in Preterm Neonates: Results from the AWAKEN Study. JAMA Pediatrics, 172, e180322.
https://doi.org/10.1001/jamapediatrics.2018.0322
[13]
Felipin, L.C.S., Oliveira, R.R., Merino, M.F.G.L., Rodrigues, B.C. and Higarashi, I.H. (2019) Associated Factors for Acute Kidney Injury in Preterm Infants. Revista Brasileira de Enfermagem, 72, 118-124. https://doi.org/10.1590/0034-7167-2018-0231
[14]
Zohdi, V., Sutherland, M.R., Lim, K., Gubhaju, L., Zimanyi, M.A. and Black, M.J. (2012) Low Birth Weight Due to Intrauterine Growth Restriction and/or Preterm Birth: Effects on Nephron Number and Long-Term Renal Health. International Journal of Nephrology, 2012, Article ID: 136942.
https://doi.org/10.1155/2012/136942
[15]
Bansal, S.C., Nimbalkar, A.S., Kungwani, A.R., Patel, D.V., Sethi, A.R. and Nimbalkar, S.M. (2017) Clinical Profile and Outcome of Newborns with Acute Kidney Injury in a Level 3 Neonatal Unit in Western India. Journal of Clinical and Diagnostic Research, 11, SC01-SC04.
[16]
Selewski, D.T., Jordan, B.K., Askenazi, D.J., Dechert, R.E. and Sarkar, S. (2013) Acute Kidney Injury in Asphyxiated Newborns Treated with Therapeutic Hypothermia. The Journal of Pediatrics, 162, 725-729.
https://doi.org/10.1016/j.jpeds.2012.10.002
[17]
Nagaraj, N., Berwal, P.K., Srinivas, A. and Berwal, A. (2016) A Study of Acute Kidney Injury in Hospitalized Preterm Neonates in NICU. Journal of Neonatal-Perinatal Medicine, 9, 417-421. https://doi.org/10.3233/NPM-161614
[18]
Srinivasan, N., Schwartz, A., John, E., Price, R. and Amin, S. (2018) Acute Kidney Injury Impairs Postnatal Renal Adaptation and Increases Morbidity and Mortality in Very Low-Birth-Weight Infants. The American Journal of Perinatology, 35, 39-47.
https://doi.org/10.1055/s-0037-1604470
[19]
Jetton, J.G., Guillet, R. and Askenazi, D.J. (2016) Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates: Design of a Retrospective Cohort Study. Frontiers in Pediatrics, 4, 68. https://doi.org/10.3389/fped.2016.00068
