Application of Well-Known Antiviral Drugs in the Field Formed by the Unexplained Properties of Low-Level Laser Radiation in Therapy of Covid-19 and Chronic Viral Hepatitis
Low-level laser therapy (LLLT) or cold laser has been used in medicine for several decades. However, the method utilizes a direct contact of the light beam with a patient. Further research resulted in development of another method that enables remote transmission of the pharmacological properties of a medicament into a human body with the application of low-level laser radiation as the light source. 18 patients with different viral diseases were treated with the antiviral drugs placed into the field formed by the unexplained properties of low-level laser radiation of the “device for transfer of the pharmacological properties of a drug into the patient’s body”. This resulted in improvement of the patient’s condition, the absence of side effects and adverse reactions when using drugs in the proposed device and shortened therapy period for patients with chronic hepatitis C infection and Covid-19 patients. The long-term follow-up of the patients with chronic hepatitis B infection showed that hepatitis B virus remained at low replication levels under the influence of the therapy, which made it possible to avoid such formidable complications of the disease as cirrhosis of the liver and liver cancer.
References
[1]
Fonseca, A.S., Moreira, T.O., Paixão, D.L., Farias, F.M., Guimarães, O.R., De Paoli, S., Geller, M. and De Paoli, F. (2010) Effect of Laser Therapy on DNA Damage. Lasers in Surgery and Medicine, 42, 481-488. https://doi.org/10.1002/lsm.20921
[2]
Tuby, H., Maltz, L. and Oron, U. (2014) Induction of Autologous Bone-Marrow Stem Cells by Low-Level Laser Therapy Has Beneficial Effects on the Kidneys Post-Ischemia-Reperfusion Injury in the Rat. Journal of Biomedical Science and Engineering, 7, 453-463. https://doi.org/10.4236/jbise.2014.78048
[3]
Mussttafa, R.A., Jenkinsa, D.F. and Jhab, A.N. (2019) Assessing the Impact of Low Level Laser Therapy (LLLT) on Biological Systems: A Review. International Journal of Radiation Biology, 95, 120-143. https://doi.org/10.1080/09553002.2019.1524944
[4]
Huang, Y.-Y., Nagata, K., Tedford, C.E. and Hamblin, M.R. (2014) Low-Level Laser Therapy (810 nm) Protects Primary Cortical Neurons against Excitotoxicity in Vitro. Journal of Biophotonics, 7, 656-664. https://doi.org/10.1002/jbio.201300125
[5]
Di Giacomo, P., Orlando, S., Dell’ariccia, M. and Brandimarte, B. (2013) Low-Level Laser Therapy: Laser Radiation Absorption in Biological Tissues. Applied Physics A, 112, 71-75. https://doi.org/10.1007/s00339-012-7204-z
[6]
Silveira, P.C., da Silva, L.A., Fraga, D.B., Freitas, T.P., Streck, E.L. and Pinho, R. (2009) Evaluation of Mitochondrial Respiratory Chain Activity in Muscle Healing by Low-Level Laser Therapy. Journal of Photochemistry and Photobiology B: Biology, 95, 89-92. https://doi.org/10.1016/j.jphotobiol.2009.01.004
[7]
Canuto, K, Sergio, L., Guimarães, O., Geller, M., Paoli, F. and Fonseca, A. (2015) Low-Level Red Laser Therapy Alters Effects of Ultraviolet C Radiation on Escherichia Coli Cells. Brazilian Journal of Medical and Biological Research, 48, 939-944. https://doi.org/10.1590/1414-431X20154459
[8]
Burduli, N.M. and Krifaridi, A.S. (2009) Effect of Low-Intensity Laser Radiation on the Function of Vascular Endothelium in Patients with Chronic Viral Hepatitis. Med (Russia), 87, 49-52.
[9]
Kaznacheev, V.P, Trofimov, A.V and Shatarin, A.Y. (2001) Device for Remote Information Transmission from Medicinal Preparation to Human Organism. RU Patent No. 2163491C2.
[10]
Oliveira, A. (2016) Electroacupuncture According to Voll: Historical Background and Literature Rreview. The Journal of Acupuncture and Oriental Medicine, 3, 5-10. https://www.researchgate.net/publication/290437736
Sulkowski, M.S, Gardiner, D.F, Rodriguez-Torres, M., Reddy, K.R, et al. (2014) Daclatasvir plus Sofosbuvir for Previously Treated or Untreated Chronic HCV Infection. New England Journal of Medicine, 370, 1469. https://doi.org/10.1056/NEJMx140011
[13]
World Gastroenterology Organisation (2015) World Gastroenterology Organisation Practice Guideline. https://www.worldgastroenterology.org/UserFiles/file/guidelines/hepatitis-b-english-2015.pdf
[14]
Omrani, S., Saad, M., Baig, K., Bahloul, A., Abdul-Matin, M., Alaidaroos, A.Y., et al. (2014) Ribavirin and Interferon alfa-2a for Severe Middle East Respiratory Syndrome Coronavirus Infection: A Retrospective Cohort Study. Lancet Infectious Diseases, 14, 1090-1095. https://doi.org/10.1016/S1473-3099(14)70920-X
[15]
Laércio Dias, L. and Moraes, F. (2005) Effects of Torsion on Electromagnetic Fields. Brazilian Journal of Physics, 35, 636-640. https://doi.org/10.1590/S0103-97332005000400009
[16]
Sliney, D. (2016) What Is Light? The Visible Spectrum and Beyond. Eye, 30, Article 222-229. https://doi.org/10.1038/eye.2015.252
[17]
Kozyrev, N. A. (1971) On the Possibility of Experimental Investigation of the Properties of Time. In: Time in Science and Philosophy, Prague, 111-132.
[18]
Kaznacheev, V.P., Kiselnikov, A.A. and Mingasov, I.F. (2005) Noospheric Ecology and Human Economics: Problems of the “Sphinx of the XXI Century. Novosibirsk, 447 p. [in Russian].
[19]
Kaznacheev, V.P. and Trofimav, A.V. (2004) Essays on the Nature of Living Matter and Intelligence on Planet Earth: Problems of Cosmoplanetars. Anthropoecology. In: Kaznacheev, V.P. and Trofimov, A.V., Eds., Science, 293-312. [in Russian] https://web.archive.org/web/20170530181521/ http://elib1.ngonb.ru/jspui/handle/NGONB/676
[20]
Djumaeva, N.E. (2000) Electroacupucture Diagnosis by Voll and Bio-Information Methods of Therapy in Different Group of Patients with Chronic Hepatitis B Infection. Ph.D Thesis, Scientific-Research Institute of Epidemiology, Microbiology and Infectious Diseases, Tashkent.
[21]
Djumaeva, N. and Djumaeva, L. (2005) Method for the Treatment of Somatic Diseases. Patent of Uzbekistan No. IDP 03033.
[22]
Dixit, N.M. and Perelson, A.S. (2006) The Metabolism, Pharmacokinetics and Mechanisms of Antiviral Activity of Ribavirin against Hepatitis C Virus. Cellular and Molecular Life Sciences CMLS, 63, 832-842. https://doi.org/10.1007/s00018-005-5455-y
[23]
Montagnier, L., Aãissa, J., Ferris, S., Montagnier, J.-L. and Lavalléee, C. (2009) Electromagnetic Signals Are Produced by Aqueous Nanostructures Derived from Bacterial DNA Sequences. Interdisciplinary Sciences: Computational Life Sciences, 1, 81-90. https://doi.org/10.1007/s12539-009-0036-7
[24]
Kaznacheev, V.P., Mihaylova, M.P. and Shurin, S.P. (1966) The Phenomenon of Intercellular Distant Electromagnetic Interactions in the System of Two Tissue Cultures. State Register of Discoveries of the USSR No. 122. [In Russian]
[25]
Kaznacheev, V.P. and Mihaylova, M.P. (1981) Ultra-Weak Radiations in Intercellular Interactions. Science, Novosibirsk. [In Russian]
[26]
Prindle, A., Liu, J., Asally, M., San, L., Garcia-Ojalvo, J. and Süel, G.M. (2015) Ion Channels Enable Electrical Communication in Bacterial Communities. Nature, 527, 59-63. https://doi.org/10.1038/nature15709
