Introduction: The efficacy of dexamethasone in reducing periorbital edema and ecchymosis following rhinoplasty was investigated in a double-blind, randomized trial. Materials & Methods: The study comprised fifty-four rhinoplasty patients who underwent open rhinoplasty surgery with tip modification, hump excision, and bilateral osteotomy and were divided into three groups: Group one: 18 patients: a single dosage of 8 mg dexamethasone given at the start of the procedure. Group two: 18 patients: three 8 mg dexamethasone doses given at the start of the procedure, then 24 and 48 hours afterwards. Group 3: a control group of 18 patients who were not given any medication. Result: In comparison to control group 3, there was a significant reduction in periorbital edema and ecchymosis in groups l and 2. Group 2 had less periorbital edema and ecchymosis at the end of the first postoperative week than group 1. Conclusion: Edema and ecchymosis were significantly reduced with dexamethasone administration in rhinoplasty with osteotomy. Use of three doses of dexamethasone can reduce edema and ecchymosis after rhinoplasty more than the single dose treatment during the first postoperative week.
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