Objective: To investigate the effect of aspirin on pregnancy outcome and serum
levels of endothelin-1 (ET-1) and thrombomodulin (TM) in pregnancy patients
with chronic hypertension. Methods: Selected patients with chronic
hypertension (mild to moderate) during pregnancy, who were enrolled and
delivered in the Beijing Tongren Hospital Department of Obstetrics and Gynecology
between January 1, 2019 and December 30, 2020. The patients were randomly
divided into control group (60) and experimental group (60). The control group
was treated with labetalol and the test group was treated with labetalol and
aspirin. The therapeutic effect and pregnancy outcome of the two groups were
compared. The serum levels of ET-1 and TM were measured before treatment and
one week after treatment. Results: Systolic blood pressure (SBP)
decreased significantly one week after treatment in the two groups (P <
0.05). One week after treatment, the values of ET-1 and TM in the experimental
group were significantly lower than those in the Control Group, the difference
is statistically significant (P < 0.05). The incidence of Preeclampsia,
intrauterine growth retardation, oligohydramnios, placental abruption, Cesarean
section and preterm birth in the experimental group was significantly lower
than that in the control group. There was significant difference between the
two groups, especially Preeclampsia and Intrauterine Growth Retardation (P <
0.05). Conclusion: Besides routine treatment, aspirin can improve the
outcome of pregnant women with chronic hypertension, which may be related to
the regulation of ET-1 and TM by aspirin.
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