Prevalence, Risk Factors and Intra-Hospital Outcomes Relating to Peri-Intraventricular Hemorrhage in Premature Newborns of Gestational Age Less than 34 Weeks
Peri-intraventricular
hemorrhage is one of the main causes of neurological impairment in premature
newborns. To control their risk factors is necessary in view
of the increasing survival of extreme preterm infants. Objective: To evaluate the prevalence of peri-intraventricular hemorrhage in premature
newborns, identify the risk factors and observe the frequencies of
intra-hospital outcomes of interests. Methods:This study was done in Brazil. This was an observational, analytical longitudinal and prospective study. The subjects included were newborns of gestational age less than
34 weeks who were admitted to two public hospitals between May and November
2015. To assess possible associated factors, obstetric, perinatal and neonatal data were analyzed
(chorioamnionitis, antenatal corticosteroids, gestational age, newborn weight,
Apgar score at 1 and 5 minutes, resuscitation in the delivery room, surfactant
in the delivery room, newborn transferred from another hospital, respiratory
distress syndrome: RDS,
sepsis, umbilical vein catheterization, assisted ventilation, exogenous
surfactant in the Neonatal ICU, use of sodium bicarbonate, inotropic agents,
adrenaline, volume expanders and blood
products). The hospital outcomes studied were assisted ventilation
References
[1]
Lee, J.Y., Kim, H.S., Jung, E., Kim, E.S., Shim, G.H., Lee, H.J., et al. (2010) Risk Factors for Periventricular-Intraventricular Hemorrhage in Premature Infants. Journal of Korean Medical Science, 25, 418-424.
[2]
Payne, A.H., Hintz, S.R., Hibbs, A.M., Walsh, M.C., Vohr, B.R., Bann, C.M., et al. (2013) Neurodevelopmental Outcomes of Extremely Low-Gestational-Age Neonates with Low-Grade Periventricular-Intraventricular Hemorrhage. JAMA Pediatrics, 167, 451-459. https://doi.org/10.1001/jamapediatrics.2013.866
[3]
Tsai, A.J., Lasky, R.E., John, S.D., Evans, P.W. and Kennedy, K.A. (2014) Predictors of Neurodevelopmental Outcomes in Preterm Infants with Intraparenchymal Hemorrhage. Journal of Perinatology, 34, 399-404. https://doi.org/10.1038/jp.2014.21
[4]
Bolisetty, S., Dhawan, A., Abdel-Latif, M., Bajuk, B., Stack, J. and Lui, K. (2014) Intraventricular Hemorrhage and Neurodevelopmental Outcomes in Extreme Preterm Infants. Pediatrics, 133, 55-62. https://doi.org/10.1542/peds.2013-0372
Su, B.H., Hsieh, W.S., Hsu, C.H., Chang, J.H., Lie, R. and Lin, C.H. (2015) Neonatal Outcomes of Extremely Preterm Infants from Taiwan: Comparison with Canada, Japan, and the USA. Pediatrics & Neonatology, 56, 46-52.
https://doi.org/10.1016/j.pedneo.2014.05.002
[7]
Rede Brasileira de Pesquisas Neonatais (2014) Relatório anual 2014.
http://www.redeneonatal.fiocruz.br
[8]
Papile, L.A., Burstein, J., Burstein, R. and Koffler, H. (1978) Incidence and Evolution of Subependymal and Intraventricular Hemorrhage: A Study of Infants with Birth Weights Less than 1,500gm. The Journal of Pediatrics, 92, 529-534.
https://doi.org/10.1016/S0022-3476(78)80282-0
[9]
Brezan, F., Ritivoiu, M., Dragan, A., Codreanu, I., Raducanu, D., Feier, D., et al. (2012) Preterm Screening by Transfontanelar Ultrasound-Result of a 5 Years Cohort Study. Medical Ultrasonography, 14, 204-210.
[10]
Brouwer, A.J., Groenendaal, F., Benders, M.J. and De Vries, L.S. (2014) Early and Late Complications of Germinal Matrix-Intraventricular Haemorrhage in the Preterm Infant: What Is New? Neonatology, 106, 296-303.
https://doi.org/10.1159/000365127
[11]
Klebermass-Schrehof, K., Czaba, C., Olischar, M., Fuiko, R., Waldhoer, T., Rona, Z., et al. (2012) Impact of Low-Grade Intraventricular Hemorrhage on Long-Term Neurodevelopmental Outcome in Preterm Infants. Child’s Nervous System, 28, 2085-2092. https://doi.org/10.1007/s00381-012-1897-3
[12]
Goldstein, RF., Cotton, C.M., Shankaran, S., Gantz, M.G. and Poole, W.K. (2013) Influence of Gestational Age on Death and Neurodevelopmental Outcome in Premature Infants with Severe Intracranial Hemorrhage. Journal of Perinatology, 33, 25-32. https://doi.org/10.1038/jp.2012.91
[13]
Kim, K.R., Jung, S.W. and Kim, D.W. (2014) Risk Factors Associated with Germinal Matrix-Intraventricular Hemorrhage in Preterm Neonates. Journal of Korean Neurosurgical Society, 56, 334-337. https://doi.org/10.3340/jkns.2014.56.4.334
[14]
Caro-López, A.M., Barrera-de-León, J.C., Dominguez-Sánchez, H., Alejandrina Castillo, S.R. and Higareda-Almaraz, M.A. (2010) Evaluación de factores prenatales, perinatales Para hemorragia Intraventricular en prematuros menores de 33 semanas de edad gestacional. Gaceta medica de Mexico, 146, 376-382.
[15]
Rong, Z., Liu, H., Xia, S. and Chang, L. (2012) Risk and Protective Factors of Intraventricular Hemorrhage in Preterm Babies in Wuhan, China. Child’s Nervous System, 28, 2077-2084. https://doi.org/10.1007/s00381-012-1875-9
[16]
Castro, M.P., Rugolo, L.M.S.S. and Margotto, P.R. (2012) Sobrevida e morbidade em prematuros com menos de 32 semanas de gestação na região central do Brasil. Revista Brasileira de Ginecologia e Obstetrícia, 34, 235-242.
https://doi.org/10.1590/S0100-72032012000500008
[17]
Marba, S.T.M., Caldas, J.P.S., Vinagre, L.E.F. and Pessoto, M.A. (2011) Incidência de hemorragia Peri-intraventricular em recém-nascidos de muito baixo peso: análise de 15 anos. Jornal de Pediatria, 87, 505-511.
[18]
Caldas, J.P., Braghini, C.A., Mazzola, T.N., Vilela, M.M. and Marba, S.T. (2015) Peri-Intraventricular Hemorrhage and Oxidative and Inflammatory Stress Markers in Very-Low Birth Weight Newborns. Jornal de Pediatria, 91, 373-379.
https://doi.org/10.1016/j.jped.2014.09.008
[19]
Araújo, B.F., Zatti, H., Oliveira Filho, P.F., Coelho, M.B., Olmi, F.B., Guaresi, T.B., et al. (2011) Effect of place of birth and transport on morbidity and mortality of preterm newborns. Jornal de Pediatria, 87, 257-262.
[20]
Agarwal, P., Sriram, B. and Rajadurai, V.S. (2015) Neonatal Outcome of Extremely Preterm Asian Infants ≤ 28 Weeks over a Decade in the New Millennium. Journal of Perinatology, 35, 297-303. https://doi.org/10.1038/jp.2014.205
[21]
Pekcevik, Y., Pasinli, A., Ozer, E.A. and Erdogan, N. (2014) Risk factors of Germinal Matrix Intraventricualr Hemorrhage in Premature Infants. Iranian Journal of Pediatrics, 24, 191-197.
[22]
Lizama, O., Hernández, H., Rivera, F. and Tori, A. (2014) Incidência de la hemorragia intraventricular en prematuros de muy bajo peso y sus factores asociados en un hospital nacional de Lima. Revista Medica Herediana, 25, 60-67.
https://doi.org/10.20453/rmh.v25i2.246
[23]
Longhini, F., Jourdain, G., Ammar, F., Mokthari, M., Boithias, C., Romain, O., et al. (2015) Outcomes of Preterm Neonates Transferred between Tertiary Perinatal Centers. Pediatric Critical Care Medicine, 16, 733-738.
https://doi.org/10.1097/PCC.0000000000000482
[24]
Nayeril, F., Dalili, H., Nili, F., Amini, E., Ardehali, A., Mansoori, B.K., et al. (2013) Risk Factors for Neonatal Mortality among Very Low Birth Weight Neonates. Acta Medica Iranica, 51, 297-302.
[25]
Ogata, J.F.M., Machado Fonseca, M.C.M., Miyoshi, M.H., Almeida, M.F.B. and Guinsburg, R. (2016) Custos da hospitalização de recém-nascidos pré-termo: impacto da corticoterapia antenatal. Jornal de Pediatria, 92, 24-31.
https://doi.org/10.1016/j.jped.2015.03.004
[26]
Sousa, D.S., Sousa Júnior, A.S., Santos, A.D., Melo, E.V., Lima, S.O., Almeida Santos, M.A., et al. (2017) Morbidade em recém-nascidos prematuros de extremo baixo peso em unidade de terapia intensiva neonatal. Revista Brasileira de Saúde Materno Infantil, 17, 139-147. https://doi.org/10.1590/1806-93042017000100008
[27]
Silva, L.R., Iser, B.P., Tartare, B. and Bonett, H.S. (2015) Aspectos perinatais relacionados à hemorragia intracraniana em recém-nascidos de muito baixo peso no Sul do Brasil. Revista Brasileira de Ginecologia e Obstetrícia, 37, 159-163.
https://doi.org/10.1590/SO100-720320150004973
