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Physico-Chemicals Characterization of Quercetin from the Carica papaya Leaves by Different Extraction Techniques

DOI: 10.4236/ojpc.2021.113007, PP. 129-143

Keywords: Carica papaya, Extraction, Infrared, Liquid Chromatography, Thermal Analysis

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Abstract:

Carica papaya leaf extracts from four different extraction methods (cold-water, hot-water, sonication and supercritical fluid), were characterized using physico-chemical analysis. Sonication extraction showed the highest percentage yield of crude extracts (6.76%) and the lowest from the supercritical fluid extraction (1.83%). The Infrared (IR) spectrum of cold-water extract demonstrated the most similarity of functional group to quercetin. Likewise, the thermal analysis indicated that cold-water extract gave a quite similar Endothermic peak to quercetin with the obtained value which was 137°C and onset value which was 118°C. The liquid chromatography (LC) profile indicated that only the cold-water extract exhibited 0.203 ppm of quercetin.

References

[1]  Boshra, V. and Tajul, A.Y. (2013) Papaya—An Innovative Raw Material for Food and Pharmaceutical Processing Industry. Health and the Environment Journal, 4, 68-75.
[2]  Arvind, G., Bhowmik, D., Duraivel, S. and Harish, G. (2013) Traditional and Medicinal Uses of Carica papaya. Journal of Medicinal Plants Studies, 1, 2320-3862.
[3]  Yogiraj, V., Goyal, P.K. and Chauhan, C.S. (2015) Carica papaya Linn: An Overview. International Journal of Herbal Medicine, 2, 1-8.
[4]  David, A.V.A., Arulmoli, R. and Parasuraman, S. (2016) Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid. Pharmacognosy Reviews, 10, 84-89.
https://doi.org/10.4103/0973-7847.194044
[5]  Zandi, K., Teoh, B., Sam, S., Wong, P., Mustafa, M.R. and Abubakar, S. (2011) Antiviral Activity of Four Types of Bioflavonoid against Dengue Virus Type-2. Virology Journal, 8, 560.
https://doi.org/10.1186/1743-422X-8-560
[6]  Hubbard, G.P., Wolffram, S., Lovegrove, J.A. and Gibbins, J.M. (2004) Ingestion of Quercetin Inhibits Platelet Aggregation and Essential Components of the Collagen-Stimulated Platelet Activation Pathway in Humans. The Journal of Thrombosis and Haemostasis, 2, 2138-2145.
https://doi.org/10.1111/j.1538-7836.2004.01067.x
[7]  Wulandari, L., Retnaningtyas, Y. and Lukman, H. (2016) Analysis of Flavonoid in Medicinal Plant Extract Using Infrared Spectroscopy and Chemometrics. Journal of Analytical Methods in Chemistry, 2016, Article ID: 4696803.
https://doi.org/10.1155/2016/4696803
[8]  Stuart, B. (2004) Infrared Spectroscopy: Fundamentals and Applications. Analytical Techniques in the Sciences, Wiley, Hoboken, 1-203.
https://doi.org/10.1002/0470011149
[9]  Clas, S.-D., Dalton, C.R. and Hancock, B.C. (1999) Differential Scanning Calorimetry: Applications in Drug Development. Pharmaceutical Science & Technology Today, 2, 311-320.
https://doi.org/10.1016/S1461-5347(99)00181-9
[10]  Holler, F.J., Skoog, D.A. and Crouch, S.R. (2007) Principles of Instrumental Analysis, Sixth Edition. International Student Edition, Brooks/Cole, Pacific Grove, 1-1039.
[11]  Wang, L. and Weller, C.L. (2006) Recent Advances in Extraction of Nutraceuticals from Plants. Trends in Food Science and Technology, 17, 300-312.
https://doi.org/10.1016/j.tifs.2005.12.004
[12]  Fernandes, F.H.A., Santana, C.P., Santos, R.L., Correia, L.P., Conceição, M.M., Macêdo, R.O. and Medeiros, A.C.D. (2012) Thermal Characterization of Dried Extract of Medicinal Plant by DSC and Analytical Techniques. Journal of Thermal Analysis and Calorimetry, 113, 443-447.
https://doi.org/10.1007/s10973-012-2807-3
[13]  Banerjee, S. and Chatterjee, J. (2014) Efficient Extraction Strategies of Tea (Camellia sinensis) Biomolecules. Journal of Food Science and Technology, 52, 3158-3168.
https://doi.org/10.1007/s13197-014-1487-3
[14]  Cheng, S.Z.D., Li, C.Y., Calhoun, B.H., Zhu, L. and Zhou, W.W. (2000) Thermal Analysis: The Next Two Decades. Thermochimica Acta, 355, 59-68.
https://doi.org/10.1016/S0040-6031(00)00437-8
[15]  Hatakeyama, T. and Quinn, F.X. (1994) Thermal Analysis; Fundamentals and Applications to Polymer Science. John Wiley & Sons, New York.
[16]  Craig, D.Q.M. and Reading, M. (2007) Thermal Analysis of Pharmaceuticals. CRC Press, Boca Raton.
[17]  Kumar, P.R., Rajeevkumar, R. and Anbazhagan, S. (2012) Studies on Carica papaya Starch as a Pharmaceutical Excipient. Journal of Chemical and Pharmaceutical Research, 4, 3134-3138.
[18]  Raymond, C.R. (2006) Handbook of Pharmaceutical Excipient. Sixth Edition, Pharmaceutical Press, London, 118-121, 581-585.
[19]  Roy, A., Bahadur, S., Chanda, R. (2014) Natural Excipient Development: Need and Future. Asian Journal of Pharmaceutical Research, 4, 12-15.
[20]  Horbowicz, M. (2002) Method of Quercetin Extraction from Dry Scales of Onion. Vegetable Crops Research Bulletin, 57, 119-124.
[21]  Sultana, B., Anwar, F. and Ashraf, M. (2009) Effect of Extraction Solvent/Technique on the Antioxidant Activity of Selected Medicinal Plant Extracts. Molecules, 14, 2167-2180.
https://doi.org/10.3390/molecules14062167
[22]  Mallamace, F., Corsaro, C., Mallamace, D., Vasi, S., Vasi, C., Baglioni, P., Buldyrev, S.V., Chen, S.-H. and Stanley, H.E. (2016) Energy Landscape in Protein Folding and Unfolding. Proceedings of the National Academy of Sciences, 113, 3159-3163.
https://doi.org/10.1073/pnas.1524864113

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