The objective was to assess the outcome of pregnancies after assisted
reproductive technology (ART). It was a case-control study carried out in four
health facilities in Douala-Cameroon, over a period of five years. The cases
were pregnant women who conceived through ART and the controls were those who
conceived naturally. Cases and controls were matched for maternal age and
parity (one case for two controls). A logistic regression analysis was used to
compute Odds ratios. Statistical significance was set at 0.05. A total of 174
women who conceived through ART and 348 who conceived naturally were enrolled.
Some independent factors associated with ART were: age over 45 years [aOR:7.55;95%CI(1.55 -
36.76); p:0.01], twin pregnancies [aOR:16.55;95%CI (7.91
- 34.60); p < 0.01], Cervical cerclage [aOR:
References
[1]
WHO (2020) Infertility Definitions and Terminology.
https://www.who.int/reproductivehealth/topics/infertility/definitions/en
[2]
Mascarenhas, M.N., Flaxman, S.R., Boerma, T., Vanderpoel, S. and Stevens, G.A. (2012) National, Regional, and Global Trends in Infertility Prevalence since 1990: A Systematic Analysis of 277 Health Surveys. PLOS Medicine, 9, e1001356.
https://doi.org/10.1371/journal.pmed.1001356
[3]
Larsen, U. (2000) Primary and Secondary Infertility in Sub-Saharan Africa. International Journal of Epidemiology, 29, 285-291. https://doi.org/10.1093/ije/29.2.285
[4]
Larsen, U. (2003) Infertility in Central Africa. Tropical Medicine & International Health, 8, 354-367. https://doi.org/10.1046/j.1365-3156.2003.01039.x
[5]
Adamson, G.D., Macaluso, M., Tabangin, M. and de Mouzon, J. (2013) The Number of Babies Born Globally after Treatment with the Assisted Reproductive Technologies (ART). Fertility and Sterility, 100, S42.
https://doi.org/10.1016/j.fertnstert.2013.07.1807
Omokanye, L.O., Olatinwo, A.O., Salaudeen, G.A., Durowade, K.A., Panti, A.A. and Balogun, R.O. (2018) Assisted Reproduction Technology in Nigeria: Challenges and the Way Forward. African Journal for Infertility and Assisted Conception, 3, 2-5.
https://doi.org/10.4103/ajiac.ajiac_1_19
[8]
Allen, V.M., Wilson, R.D., Cheung, A. and Genetics Committee (2006) Reproductive Endocrinology and Infertility Committee. Pregnancy Outcomes after Assisted Reproductive Technology. Journal of Obstetrics and Gynaecology Canada, 28, 220-233. https://doi.org/10.1016/S1701-2163(16)32112-0
[9]
Tan, S.L., Doyle, P., Campbell, S., Beral, V., Rizk, B., Brinsden, P., Mason, B. and Edwards, R.G. (2002) Obstetric Outcome of in Vitro Fertilization Pregnancies Compared with Normally Conceived Pregnancies. American Journal of Obstetrics & Gynecology, 167, 778-784. https://doi.org/10.1016/S0002-9378(11)91589-0
[10]
American College of Obstetricians and Gynecologists, Committee Opinion No. 671 (Reaffirmed 2020), Committee on Obstetric Practice, Committee on Genetics (2016) Perinatal Risks Associated with Assisted Reproductive Technology.
https://www.acog.org/-/media/project/acog/acogorg/clinical/files/committee-opinion/articles/2016/09/perinatal-risks-associated-with-assisted-reproductive-technology.pdf
[11]
Jackson, R.A., Gibson, K.A., Wu, Y.W. and Croughan, M.S. (2004) Perinatal Outcomes in Singletons Following in Vitro Fertilization: A Meta-Analysis. Obstetrics & Gynecology, 103, 551-563. https://doi.org/10.1097/01.AOG.0000114989.84822.51
[12]
Qin, J., Liu, X., Sheng, X., Wang, H. and Gao, S. (2016) Assisted Reproductive Technology and the Risk of Pregnancy-Related Complications and Adverse Pregnancy Outcomes in Singleton Pregnancies: A Meta-Analysis of Cohort Studies. Fertility and Sterility, 105, 73-85.e1-6. https://doi.org/10.1016/j.fertnstert.2015.09.007
[13]
Almasi-Hashiani, A., Omani-Samani, R., Mohammadi, M., Amini, P., Navid, B., Alizadeh, A., Morasae, E.K. and Maroufizadeh, S. (2019) Assisted Reproductive Technology and the Risk of Preeclampsia: An Updated Systematic Review and Meta-Analysis. BMC Pregnancy Childbirth, 19, Article No. 149.
https://doi.org/10.1186/s12884-019-2291-x
[14]
Clayton, H.B., Schieve, L.A., Peterson, H.B., Jamieson, D.J., Reynolds, M.A. and Wright, V. (2006) Ectopic Pregnancy Risk with Assisted Reproductive Technology Procedures. Obstetrics & Gynecology, 107, 595-604.
https://doi.org/10.1097/01.AOG.0000196503.78126.62
[15]
Egbe, T.O., Sandjon, G., Ourtchingh, C., Simo, A., Priso, E.B. and Benifla, J.L. (2016) In-Vitro Fertilization and Spontaneous Pregnancies: Matching Outcomes in Douala, Cameroon. Fertility Research and Practice, 2, Article No. 1.
https://doi.org/10.1186/s40738-015-0013-2
[16]
Belinga, E., Noa Ndoua, C., Nyebe, F., Voundi, Voundi, E., Toukam, M., Ngono, V., Massin, N., Jimenez, C. and Kasia, J.M. (2019) The Outcome of Pregnancies Obtained after IVF Compared to Spontaneous Pregnancies at the Gynecological Endoscopic Surgery and Human Reproductive Teaching Hospital (GESHRTH). Clinical Obstetrics, Gynecology and Reproductive Medicine, 5, 1-4.
https://doi.org/10.15761/COGRM.1000271
[17]
Omokanye, L.O., Olatinwo, A.O., Saadu, L.O., Biliaminu, S.A., Durowade, K.A. and Panti, A.A. (2016) Assisted Reproductive Technology: Experience from a Public Tertiary Institution in North Central Nigeria. African Journal for Infertility and Assisted Conception, 1, 23-26.
[18]
Ikechebelu, J.I., Eleje, G.U., Ibadin, K., Joe-Ikechebelu, N.N., Nwaefulu, K. and Okwelogu, S.I. (2016) Outcome of in Vitro Fertilization Procedure at a Private Fertility Center in Nnewi, South-East Nigeria. African Journal for Infertility and Assisted Conception, 1, 2-5. https://doi.org/10.4103/2468-8452.189960
[19]
Silva, S.G., Da Bertoldi, A.D., Silveira, M.F., Da Domingues, M.R., Evenson, K.R. and Dos Santos, I.S. (2019) Assisted Reproductive Technology: Prevalence and Associated Factors in Southern Brazil. Revista de Saúde Pública, 53, 13.
https://doi.org/10.11606/S1518-8787.2019053000737
[20]
Källén, B. (2008) Maternal Morbidity and Mortality in In-Vitro Fertilization. Best Practice & Research: Clinical Obstetrics & Gynaecology, 22, 549-558.
https://doi.org/10.1016/j.bpobgyn.2008.02.001
[21]
Schieve, L.A., Cohen, B., Nannini, A., Ferre, C., Reynolds, M.A., Zhang, Z., Jeng, G., Macaluso, M. and Wright, V.C. (2011) A Population-Based Study of Maternal and Perinatal Outcomes Associated with Assisted Reproductive Technology in Massachusetts. Maternal and Child Health Journal, 11, 517-525.
https://doi.org/10.1007/s10995-007-0202-7
[22]
Li, C., Shen, J. and Hua, K. (2019) Cerclage for Women with Twin Pregnancies: A Systematic Review and Metaanalysis. American Journal of Obstetrics & Gynecology, 220, 543-557. https://doi.org/10.1016/j.ajog.2018.11.1105
[23]
Luke, B., Brown, M.B., Wantman, E., Stern, J.E., Baker, V.L., Widra, E., Coddington, C.C., Gibbons, W.E., Van Voorhis, B.J. and Ball, G.D. (2015) Application of a Validated Prediction Model for in Vitro Fertilization: Comparison of Live Birth Rates and Multiple Birth Rates with 1 Embryo Transferred over 2 Cycles vs 2 Embryos in 1 Cycle. American Journal of Obstetrics & Gynecology, 212, 676.e1-7.
https://doi.org/10.1016/j.ajog.2015.02.005
[24]
Wang, A.Y., Safi, N., Ali, F., Lui, K., Li, Z., Umstad, M.P. and Sullivan, E.A. (2018) Neonatal Outcomes among Twins Following Assisted Reproductive Technology: An Australian Population-Based Retrospective Cohort Study. BMC Pregnancy Childbirth, 18, 320. https://doi.org/10.1186/s12884-018-1949-0
[25]
Pezeshki, K., Feldman, J., Stein, D.E., Lobel, S.M. and Grazi, R.V. (2000) Bleeding and Spontaneous Abortion after Therapy for Infertility. Fertility and Sterility, 74, 504-508. https://doi.org/10.1016/S0015-0282(00)00707-X
