Purpose: To explore the clinical efficacy of Changmaile II
combined with cyclic estrogen/progesterone therapy in treating
hypomenorrhea caused by intrauterine adhesion
(IUA) and its effect on the endometrium after the separation procedure
for intrauterine adhesion. Methods: Sixty
patients with IUA confirmed by hysteroscopy in the Second People’s Hospital of
Fujian University of Traditional Chinese Medicine from March 2020 to December
2020 were selected and randomly divided into the control group and the
observation group, with 30 cases in each group. After the separation procedure
for intrauterine adhesion, the observation group underwent the cyclic
estrogen/progesterone therapy alone, while the observation group was
administered the in-hospital preparation of Changmaile II in addition to the
therapy of the observation group. Menstrual recovery, endometrial thickness,
and the diagnostic grading scores of IUA after 3 menstrual cycles were measured
in both groups. Results: After
the treatment for 3 menstrual cycles, the total effective rate was higher in
the observation group (73.33%) than in the control group (53.33%) (P <
0.05). The period flow was heavier in the observation group than in the control
group (P < 0.05). The endometrial thickness of both groups was thicker than
before treatment (P < 0.05), nonetheless the difference between the groups
was not statistically significant (P > 0.05). After treatment, the
diagnostic grading scores of IUA were higher in the observation group than in
the control group (P < 0.05). Conclusions: Changmaile II combined with estrogen and progesterone artificial cycle
therapy could increase the menstrual
Obstetrics and Gynecology Branch of Chinese Medical Association. (2015) Consensus of Chinese Experts on Clinical Diagnosis and Treatment of Intrauterine Adhesions. Chinese Journal of Obstetrics and Gynecology, 50, 881-887.
[3]
Hooker, A.B., de Leeuw, R., van de Ven, P.M., Bakkum, E.A., Thurkow, A.L., Vogel, N.E.A., van Vliet, H.A.A.M., Bongers, M.Y., Emanuel, M.H., Verdonkschot, A.E.M., et al. (2017) Prevalence of Intrauterine Adhesions after the Application of Hyaluronic Acid Gel after Dilatation and Curettage in Women with at Least One Previous Curettage: Short-Term Outcomes of a Multicenter, Prospective Randomized Controlled Trial. Fertility and Sterility, 107, 1223-1231. https://doi.org/10.1016/j.fertnstert.2017.02.113
[4]
Chen, Y., Liu, L., Luo, Y., et al. (2017) Effects of Aspirin and Intrauterine Balloon on Endometrial Repair and Reproductive Prognosis in Patients with Severe Intrauterine Adhesion: A Prospective Cohort Study. BioMed Research International, 2017, Article ID: 8526104. https://doi.org/10.1155/2017/8526104
[5]
Liu, Q., Chen, X.L., Huang, S.P., et al. (2020) Study on Correlation between Signs of Uterine Cavity under Hysteroscopy and TCM Syndrome Elementsin Intrauterine Adhesion. Journal of Traditional Chinese Medicine, 27, 19-23.
[6]
Xia, E.L. (2016) Hysteroscopy and Atlas. 3rd Edition, Henan Science and Technology Press, Zhengzhou, 189-192.
[7]
Cao, Z.Y. (2004) Chinese Obstetrics and Gynecology. 2nd Edition, People’s Medical Publishing House, Beijing, 2406.
[8]
Zheng, X.Y. (2002) Guiding Principles for Clinical Research of New Chinese Medicine (Trial). China Medical Science and Technology Press, Beijing.
[9]
Yan, X.Z. (2020) Research Advances in Prevention of Readhesion after Transcervical Resection of Adhesions. Luzhou Medical College, 43, 429-433.
