高尿酸血症及尿酸盐转运蛋白研究进展
Research Progress of Hyperuricemia and Urate Transporter

DOI: 10.12677/PI.2021.103020, PP. 147-151

Keywords: 高尿酸血症，痛风，尿酸盐转运蛋白
Hyperuricemia, Gout, Urate Transporter

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Abstract:

高尿酸血症(hyperuricemia, HUA)及痛风以往被认为是由于人体嘌呤代谢异常所导致的代谢性风湿病。2002年，Enomoto等人描述了第一个肾脏尿酸盐转运蛋白URAT1 (urate anion transporter 1)，之后，越来越多的尿酸盐转运蛋白被表征，高尿酸血症不再是一种代谢性疾病，而是一种“转运疾病”。本篇综述回顾了近几年与HUA及尿酸盐转运蛋白相关的国内外研究文献，对尿酸盐转运蛋白与HUA疾病的相关关系进行总结。
Hyperuricemia and gout were previously thought to be metabolic rheumatism caused by abnormal purine metabolism in the body. In 2002, Enomoto et al. described the first renal urate transporter URAT1. Since then, more and more urate transporters have been characterized. Hyperuricemia is no longer a metabolic disease, but a “transport disease”. This review reviews the domestic and foreign research literature related to HUA and urate transporter in recent years, and summarizes the relationship between urate transporter and HUA disease.

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