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铋基纳米材料的制备及其在肿瘤诊疗中的研究进展
Research Progress in Preparation and Theranostics of Bismuth-Based Nanomaterials

DOI: 10.12677/NAT.2021.112003, PP. 19-26

Keywords: 铋基纳米材料,生物医学,生物成像,肿瘤诊疗
Bismuth-Based Nanomaterials
, Biomedicine, Bioimaging, Theranostics

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Abstract:

随着纳米技术的快速发展,以纳米材料为基础的新型生物材料在生物医学领域表现出独特的优势,因而受到研究人员的广泛关注。铋(bismuth, Bi)基纳米材料因其良好的生物相容性和优异的光学、电学等物理化学特性,在药物递送、抗菌、组织工程、生物传感、肿瘤治疗等生物医学领域的应用已被广泛研究和报道;特别地,在生物成像及癌症诊疗方面展现出广阔的应用潜力。本文结合实例简要综述了生物医用铋基纳米材料的常见类型和制备方法,总结了其在计算机断层扫描(CT)成像、光声(PA)等生物成像和光热治疗、放射治疗等肿瘤诊疗中的最新研究进展,并在此基础上对其在生物医学中的应用前景进行了展望和对挑战展开了分析。
With the rapid development of nanotechnology, the novel nanomaterial-based biomaterials can effectively overcome the disadvantages resulted from traditional biomaterials to promote the development of biomedicine, therefore have received wide attention from researchers. Because of their good biocompatibility and excellent physicochemical properties such as optical, electrical and magnetic characteristics, bismuth-based nanomaterials have been extensively studied and reported in biomedical fields such as drug delivery, antibacterial, tissue engineering, biosensors, tumor treatment, especially in bioimaging and theranostics applications. Combined with the reported studies, this paper briefly reviews the common types and synthesis methods of biomedical bismuth-based nanomaterials, and summarizes the latest research progress in bioimaging (such as computed tomography (CT) and photoacoustic imaging) and in theranostics (such as photothermal therapy (PTT) and radiotherapy). Finally, on this basis the prospects and challenges of bismuth-based nanomaterials for the biomedical applications in the future are expected.

References

[1]  Salvador, J.A.R., Figueiredo, S.A.C., Pinto, R.M.A., et al. (2012) Bismuth Compounds in Medicinal Chemistry. Future Medicinal Chemistry, 4, 1495-1523.
https://doi.org/10.4155/fmc.12.95
[2]  Shahbazi, M.A., Faghfouri, L., Ferreira, M.P.A., et al. (2020) The Versatile Biomedical Applications of Bismuth- Based Nanoparticles and Composites: Thera-peutic, Diagnostic, Biosensing, and Regenerative Properties. Chemical Society Reviews, 49, 1253-1321.
https://doi.org/10.1039/C9CS00283A
[3]  Guo, Z., Zhu, S., Yong, Y., et al. (2017) Synthesis of BSA-Coated Bi-OI@ Bi2S3 Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic Therapy of Tumor. Advanced Materials, 29, Article ID: 1704136.
https://doi.org/10.1002/adma.201704136
[4]  Liu, J., Zheng, X., Yan, L., et al. (2015) Bismuth Sulfide Nanorods as a Precision Nanomedicine for in Vivo Multimodal Imaging-Guided Photothermal Therapy of Tumor. ACS Nano, 9, 696-707.
https://doi.org/10.1021/nn506137n
[5]  Zang, Y., Gong, L., Mei, L., et al. (2019) Bi2WO6 Semiconduc-tor Nanoplates for Tumor Radiosensitization through High-Z Effects and Radiocatalysis. ACS Applied Materials & In-terfaces, 11, 18942-18952.
https://doi.org/10.1021/acsami.9b03636
[6]  Ai, K., Liu, Y., Liu, J., et al. (2011) Large-Scale Synthesis of Bi2S3 Nanodots as a Contrast Agent for in Vivo X-Ray Computed Tomography Imaging. Advanced Materials, 23, 4886-4891.
https://doi.org/10.1002/adma.201103289
[7]  Lei, P., An, R., Zhang, P., et al. (2017) Ultrafast Synthesis of Ul-trasmall Poly(Vinylpyrrolidone)-Protected Bismuth Nanodots as a Multifunctional Theranostic Agent for in Vivo Du-al-Modal CT/Photothermal-Imaging-Guided Photothermal Therapy. Advanced Functional Materials, 27, Article ID: 1702018.
https://doi.org/10.1002/adfm.201702018
[8]  Zhou, R., Liu, X., Wu, Y., et al. (2020) Suppressing the Radiation-Induced Corrosion of Bismuth Nanoparticles for Enhanced Synergistic Cancer Radiophototherapy. ACS Nano, 14, 13016-13029.
https://doi.org/10.1021/acsnano.0c04375
[9]  Zhou, D., Li, C., He, M., et al. (2016) Folate-Targeted Perfluoro-hexane Nanoparticles Carrying Bismuth Sulfide for Use in US/CT Dual-Mode Imaging and Synergistic High-Intensity Focused Ultrasound Ablation of Cervical Cancer. Journal of Materials Chemistry B, 4, 4164-4181.
https://doi.org/10.1039/C6TB00261G
[10]  Kinsella, J.M., Jimenez, R.E., Karmali, P.P., et al. (2011) X-Ray Com-puted Tomography Imaging of Breast Cancer by Using Targeted Peptide-Labeled Bismuth Sulfide Nanoparticles. An-gewandte Chemie International Edition, 50, 12308- 12311.
https://doi.org/10.1002/anie.201104507
[11]  Liao, W., Lei, P., Pan, J., et al. (2019) Bi-DTPA as a High-Performance CT Contrast Agent for in Vivo Imaging. Biomaterials, 203, 1-11.
https://doi.org/10.1016/j.biomaterials.2019.03.001
[12]  Wang, X., Guo, Z., Zhang, C., et al. (2020) Ul-trasmall BiOI Quantum Dots with Efficient Renal Clearance for Enhanced Radiotherapy of Cancer. Advanced Science, 7, Article ID: 1902561.
https://doi.org/10.1002/advs.201902561
[13]  Zheng, X., Shi, J., Bu, Y., et al. (2015) Sili-ca-Coated Bismuth Sulfide Nanorods as Multimodal Contrast Agents for a Non-Invasive Visualization of the Gastroin-testinal Tract. Nanoscale, 7, 12581-12591.
https://doi.org/10.1039/C5NR03068D
[14]  Park, S., Park, G., Kim, J., et al. (2018) Bi2Se3 Nanoplates for Con-trast-Enhanced Photoacoustic Imaging at 1064 nm. Nanoscale, 10, 20548-20558.
https://doi.org/10.1039/C8NR05672B
[15]  Li, Z., Hu, Y., Miao, Z., et al. (2018) Dual-Stimuli Responsive Bismuth Nanoraspberries for Multimodal Imaging and Combined Cancer Therapy. Nano Letters, 18, 6778-6788.
https://doi.org/10.1021/acs.nanolett.8b02639
[16]  Lei, P., Zhang, P., Yuan, Q., et al. (2015) Yb3+/Er3+-Codoped Bi2O3 Nanospheres: Probe for Upconversion Luminescence Imaging and Binary Contrast Agent for Computed Tomog-raphy Imaging. ACS Applied Materials & Interfaces, 7, 26346-26354.
https://doi.org/10.1021/acsami.5b09990
[17]  Li, Y., Sun, Y., Cao, T., et al. (2017) A Cation-Exchange Controlled Core-Shell MnS@ Bi2S3 Theranostic Platform for Multimodal Imaging Guided Radiation Therapy with Hyperthermia Boost. Nanoscale, 9, 14364-14375.
https://doi.org/10.1039/C7NR02384G
[18]  Yang, Y., Wu, H., Shi, B., et al. (2015) Hydrophilic Cu3BiS3 Nanopar-ticles for Computed Tomography Imaging and Photothermal Therapy. Particle & Particle Systems Characterization, 32, 668-679.
https://doi.org/10.1002/ppsc.201400238
[19]  Yu, X., Li, A., Zhao, C., et al. (2017) Ultrasmall Semimetal Nanopar-ticles of Bismuth for Dual-Modal Computed Tomography/Photoacoustic Imaging and Synergistic Thermoradiotherapy. ACS Nano, 11, 3990-4001.
https://doi.org/10.1021/acsnano.7b00476
[20]  Li, Z., Ai, K., Yang, Z., et al. (2017) Untrasmall Bi2S3 Nanodots for in Vivo X-Ray CT Imaging-Guided Photothermal Therapy of Cancer. RSC Advances, 7, 29672-29678.
https://doi.org/10.1039/C7RA04132B
[21]  Xiao, Z., Xu, C., Jiang, X., et al. (2016) Hydrophilic Bismuth Sulfur Nanoflower Superstructures with an Improved Photothermal Efficiency for Ablation of Cancer Cells. Nano Research, 9, 1934-1947.
https://doi.org/10.1007/s12274-016-1085-y
[22]  Xie, H., Li, Z., Sun, Z., et al. (2016) Metabolizable Ultrathin Bi2Se3 Nanosheets in Imaging-Guided Photothermal Therapy. Small, 12, 4136-4145.
https://doi.org/10.1002/smll.201601050
[23]  Zhou, S.M., Ma, D.K., Zhang, S.H., et al. (2016) PEGylated Cu3BiS3 Hollow Nanospheres as a New Photothermal Agent for 980 nm-Laser-Driven Photothermochemotherapy and a Contrast Agent for X-Ray Computed Tomography Imaging. Nanoscale, 8, 1374-1382.
https://doi.org/10.1039/C5NR06041A
[24]  龚林吉, 谢佳妮, 朱双, 等. 多功能纳米材料在肿瘤放疗增敏中的应用[J]. 物理化学学报, 2017, 34(2): 140-167.

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