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Study of Vitamin D Status in Pneumonia among Children between 6 Months to 3 Years of Age

DOI: 10.4236/ojped.2021.112025, PP. 254-267

Keywords: Pediatrics, LRTIs, 1,25(OH)2 D, Respiratory

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Abstract:

Background: In the developing world, pneumonia is not only more common than it is in Europe or North America; it is also more severe and considered the leading cause of under-five mortality. Effective management of pneumonia in children under 3-year-old-age is still challenging due to various causes. Some authors believed in non-calcemic role of vitamin D as a potential factor in the pathogenesis, prevention, or therapy of pneumonia in this specific age. Purpose: Investigate the Vitamin D status in pneumonia among children between 6 months to 3 years of age. Subjects and Methods: This study was conducted in a Pediatric point of care at Al-Zahraa University Hospital on 90 children aged 6 months to 3 years old; divided into two groups: group I (study group) including 47 patients presented with pneumonia and group II (control group) including 43 apparently healthy children of matched age and sex with no evidence of pneumonia. Serum vitamin D was estimated with specific inclusion and exclusion criteria. Results: The vitamin D level showed no significant difference between the two groups of the study. Conclusion: Possible role of vitamin D in disease process of pneumonia in children between 6 months to 3 years could not be assured.

References

[1]  Yadav, R.K., Kumar, D., Singh, A., Ziauddin, M. and Singh, D.K. (2021) Clinical and Microbial Spectrum of Community-Acquired Pneumonia in Children of North India. Tropical Doctor, 51, 71-77.
https://doi.org/10.1177/0049475520971595
[2]  Rabee, M.A., El Nahass, N.G., Abdeen, H.A. and El Kader, F.A. (2020) Efficacy of Interval Training on Quality of Life in Women with Vitamin D Deficiency. Medical Journal of Cairo University, 88, 1507-1512.
https://doi.org/10.21608/mjcu.2020.116241
[3]  Ensinck, G., Lazarte, G., Ernst, A., et al. (2021) Community-Acquired Methicillin-Resistant Staphylococcus aureus Pneumonia in a Children’s Hospital. Our Ten-Year Experience. Archivos Argentinos de Pediatria, 119, 11-17.
https://doi.org/10.5546/aap.2021.eng.11
[4]  Carloni, I., Ricci, S., Rubino, C., et al. (2021) Necrotizing Pneumonia among Italian Children in the Pneumococcal Conjugate Vaccine Era. Pediatric Pulmonology, 56, 1127-1135.
https://doi.org/10.22541/au.159836223.33683043
[5]  Panfili, F.M., Roversi, M., D’argenio, P., et al. (2021) Possible Role of Vitamin D in Covid-19 Infection in Pediatric Population. Journal of Endocrinological Investigation, 44, 27-35.
https://doi.org/10.1007/s40618-020-01327-0
[6]  Shojaeefar, E., Malih, N. and Rezaei, N. (2021) The Possible Double-Edged Sword Effects of Vitamin D on COVID-19: A Hypothesis. Cell Biology International, 45, 54-57.
https://doi.org/10.1002/cbin.11469
[7]  Carlberg, C. (2018) Vitamin D Genomics: From in Vitro to in Vivo. Frontiers in Endocrinology (Lausanne), 9, 250.
https://doi.org/10.3389/fendo.2018.00250
[8]  Lipińska-Opalka, A., Tomaszewska, A., Kubiak, J.Z. and Kalicki, B. (2021) Vitamin D and Immunological Patterns of Allergic Diseases in Children. Nutrients, 13, 177.
https://doi.org/10.3390/nu7064240
[9]  Greiller, C.L. and Martineau, A.R. (2015) Modulation of the Immune Response to Respiratory Viruses by Vitamin D. Nutrients, 7, 4240-4270.
https://doi.org/10.3390/nu7064240
[10]  Bleakley, A.S., Licciardi, P.V. and Binks, M.J. (2021) Vitamin D Modulation of the Innate Immune Response to Paediatric Respiratory Pathogens Associated with Acute Lower Respiratory Infections. Nutrients, 13, 276.
https://doi.org/10.3390/nu13010276
[11]  Costenaro, P., Cantarutti, A., Barbieri, E., et al. (2021) Antibiotic Prescriptions for Children with Community-acquired Pneumonia: Findings from Italy. The Pediatric Infectious Disease Journal, 40, 130-136.
https://doi.org/10.1097/INF.0000000000002934
[12]  Xiao, L., Xing, C., Yang, Z., et al. (2015) Vitamin D Supplementation for the Prevention of Childhood Acute Respiratory Infections: A Systematic Review of Randomised Controlled Trials. British Journal of Nutrition, 114, 1026-1034.
https://doi.org/10.1017/S000711451500207X
[13]  Selvarajan, S., Gunaseelan, V., Anandabaskar, N., et al. (2017) Systematic Review on Vitamin D Level in Apparently Healthy Indian Population and Analysis of Its Associated Factors. Indian Journal of Endocrinology and Metabolism, 21, 765-775.
https://doi.org/10.4103/ijem.IJEM_168_17
[14]  Angelidi, A.M., Belanger, M.J., Lorinsky, M.K., et al. (2021) Vitamin D Status Is Associated with In-Hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients. Mayo Clinic Proceedings, 96, 875-886.
https://doi.org/10.1016/j.mayocp.2021.01.001
[15]  Martineau, A.R., Jolliffe, D.A., Hooper, R.L., et al. (2017) Vitamin D Supplementation to Prevent Acute Respiratory Tract Infections: Systematic Review and Meta-Analysis of Individual Participant Data. BMJ, 356, i6583.
[16]  Mao, S. and Huang, S. (2013) Vitamin D Supplementation and Risk of Respiratory Tract Infections: A Meta-Analysis of Randomized Controlled Trials. Scandinavian Journal of Infectious Diseases, 45, 696-702.
https://doi.org/10.3109/00365548.2013.803293
[17]  Vuichard Gysin, D., Dao, D., Gysin, C.M., Lytvyn, L. and Loeb, M. (2016) Effect of Vitamin D3 Supplementation on Respiratory Tract Infections in Healthy Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS ONE, 11, e0162996.
https://doi.org/10.1371/journal.pone.0162996
[18]  Das, R.R., Singh, M. and Naik, S.S. (2018) Vitamin D as an Adjunct to Antibiotics for the Treatment of Acute Childhood Pneumonia. Cochrane Database of Systematic Reviews, 7, Cd011597.
https://doi.org/10.1002/14651858.CD011597.pub2
[19]  Gupta, P., Dewan, P., Shah, D., et al. (2016) Vitamin D Supplementation for Treatment and Prevention of Pneumonia in Under-Five Children: A Randomized Double-Blind Placebo Controlled Trial. Indian Pediatrics, 53, 967-976.
https://doi.org/10.1007/s13312-016-0970-5
[20]  Litonjua, A.A., Carey, V.J., Laranjo, N., et al. (2020) Six-Year Follow-Up of a Trial of Antenatal Vitamin D for Asthma Reduction. The New England Journal of Medicine, 382, 525-533.
https://doi.org/10.1056/NEJMoa1906137
[21]  Feng, X., Wu, H., Grossman, J.M., et al. (2006) Association of Increased Interferon-Inducible Gene Expression with Disease Activity and Lupus Nephritis in Patients with Systemic Lupus Erythematosus. Arthritis & Rheumatism, 54, 2951-2962.
https://doi.org/10.1002/art.22044
[22]  Yakoob, M.Y., Salam, R.A., Khan, F.R. and Bhutta, Z.A. (2016) Vitamin D Supplementation for Preventing Infections in Children under Five Years of Age. Cochrane Database of Systematic Reviews Review, 11, Cd008824.
https://doi.org/10.1002/14651858.CD008824.pub2
[23]  Remmelts, H.H., Spoorenberg, S.M., Oosterheert, J.J., et al. (2013) The Role of Vitamin D Supplementation in the Risk of Developing Pneumonia: Three Independent Case-Control Studies. Thorax, 68, 990-996.
https://doi.org/10.1136/thoraxjnl-2013-203623
[24]  Amrein, K., Scherkl, M., Hoffmann, M., et al. (2020) Vitamin D Deficiency 2.0: An Update on the Current Status Worldwide. European Journal of Clinical Nutrition, 74, 1498-1513.
https://doi.org/10.1038/s41430-020-0558-y
[25]  Chowdhury, R., Taneja, S., Kvestad, I., et al. (2020) Vitamin D Status in Early Childhood Is Not Associated with Cognitive Development and Linear Growth at 6-9 Years of Age in North Indian Children: A Cohort Study. Nutrition Journal, 19, Article No. 14.
https://doi.org/10.1186/s12937-020-00530-2
[26]  Mamani, M., Muceli, N., Ghasemi Basir, H.R., Vasheghani, M. and Poorolajal, J. (2017) Association between Serum Concentration of 25-Hydroxyvitamin D and Community-Acquired Pneumonia: A Case-Control Study. International Journal of General Medicine, 10, 423-429.
https://doi.org/10.2147/IJGM.S149049
[27]  Özdemir, B., Köksal, B.T., Karakas, N.M., Tekindal, M.A. and Özbek, Ö.Y. (2016) Serum Vitamin D Levels in Children with Recurrent Respiratory Infections and Chronic Cough. The Indian Journal of Pediatrics, 83, 777-782.
https://doi.org/10.1007/s12098-015-2010-1
[28]  Naheed, A., Breiman, R.F., Islam, M.S., Saha, S.K. and Naved, R.T. (2019) Disparities by Sex in Care-Seeking Behaviors and Treatment Outcomes for Pneumonia among Children Admitted to Hospitals in Bangladesh. PLoS ONE, 14, e0213238.
https://doi.org/10.1371/journal.pone.0213238
[29]  Del Rosal, T., Caminoa, M.B., González-Guerrero, A., et al. (2020) Outcome of Severe Bacterial Pneumonia in the Era of Pneumococcal Vaccination. Frontiers in Pediatrics, 8, 576519.
https://doi.org/10.3389/fped.2020.576519
[30]  Yancey, A.L., Watson, H.L., Cartner, S.C. and Simecka, J.W. (2001) Gender Is a Major Factor in Determining the Severity of Mycoplasma Respiratory Disease in Mice. Infection and Immunity, 69, 2865-2871.
https://doi.org/10.1128/IAI.69.5.2865-2871.2001
[31]  Bénet, T., Sylla, M., Messaoudi, M., et al. (2015) Etiology and Factors Associated with Pneumonia in Children under 5 Years of Age in Mali: A Prospective Case-Control Study. PLoS ONE, 10, e0145447.
https://doi.org/10.1371/journal.pone.0145447
[32]  Weiler, H.A. (2017) Vitamin D Supplementation for Infants: Biological, Behavioural and Contextual Rationale. e-Library of Evidence for Nutrition Actions (eLENA), WHO.
[33]  Feldstein, L.R., Rose, E.B., Horwitz, S.M., et al. (2020) Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. The New England Journal of Medicine, 383, 334-346.
https://doi.org/10.1056/NEJMoa2021680
[34]  Mourad, S., Rajab, M., Alameddine, A., et al. (2010) Hemoglobin Level as a Risk Factor for Lower Respiratory Tract Infections in Lebanese Children. North American Journal of Medical Sciences, 2, 461-466.
https://doi.org/10.4297/najms.2010.2461
[35]  Rashad, M.M., Fayed, S.M. and El-Hag, A.M. (2015) Iron-Deficiency Anemia as a Risk Factor for Pneumonia in Children. Benha Medical Journal, 32, 96-100.
https://doi.org/10.4103/1110-208X.180321
[36]  Lakhani, D. and Muley, P. (2013) The Association of Positive Chest Radiograph and Laboratory Parameters with Community Acquired Pneumonia in Children. Journal of Clinical and Diagnostic Research, 7, 1629-1631.
https://doi.org/10.7860/JCDR/2013/5132.3222
[37]  Dufort, E.M., Koumans, E.H., Chow, E.J., et al. (2020) Multisystem Inflammatory Syndrome in Children in New York State. The New England Journal of Medicine, 383, 347-358.
https://doi.org/10.1056/NEJMoa2021756
[38]  Don, M. (2011) Risk Factors of Paediatric Community-Acquired Pneumonia. European Respiratory Journal, 37, 724-725; author reply 725.
https://doi.org/10.1183/09031936.00164010
[39]  Fink, C., Peters, R.L., Koplin, J.J., Brown, J. and Allen, K.J. (2019) Factors Affecting Vitamin D Status in Infants. Children, 6, 7.
https://doi.org/10.3390/children6010007
[40]  Gellert, S., Ströhle, A. and Hahn, A. (2017) Breastfeeding Woman Are at Higher Risk of Vitamin D Deficiency than Non-Breastfeeding Women—Insights from the German VitaMinFemin Study. International Breastfeeding Journal, 12, Article No. 19.
https://doi.org/10.1186/s13006-017-0105-1
[41]  Tan, M.L., Abrams, S.A. and Osborn, D.A. (2018) Vitamin D Supplementation for Term Breastfed Infants to Prevent Vitamin D Deficiency and Improve Bone Health. The Cochrane Database of Systematic Reviews, 12, CD013046.
https://doi.org/10.1002/14651858.CD013046

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