A 32-year-old patient with no previous history was admitted for chest
pain, dyspnea, appetite and weight loss.Chest X-ray revealed an opacity involving the lower two-thirds of the right hemithorax, suggestive
of a pleural effusion. Because of the
absence of fluid return even after ultrasound-guided thoracentesis, a Chest Computed tomography
was required showing a heterogeneous anterior mediastinal mass with soft
tissue, fat, fluid and calcifications associated with extensive encysted fluid collection in the right hemithorax. A video-assisted mini-thoracotomy revealed a mediastinal tumor firmly attached to
the thymus with a cystic wall lined by
squamous epithelium and sebaceous gland composed of respiratory tissue,
adipose tissue, cartilage,smooth muscle fibers, and well-differentiated
pancreatic tissue. These findings led to the diagnosis of a mature thymic
teratoma.The patient was discharged 7 days after surgery,
with no recurrence on follow-up.
References
[1]
Tian, Z.H., Liu, H.S., Li, S.Q., Chen, Y.Y., Ma, D.J., Han, Z.J., et al. (2020) Surgical Treatment of Benign Mediastinal Teratoma: Summary of Experience of 108 Cases. Journal of Cardiothoracic Surgery, 15, Article No. 36.
https://doi.org/10.1186/s13019-020-1075-8
[2]
Dulmet, E.M., Macchiarini, P., Suc, B. and Verley, J.M. (1993) Germ Cell Tumors of the Mediastinum. A 30-Year Experience. Cancer, 72, 1894-1901.
Ryan, E., Shennib, H. and Gopal, S.J. (2019) Giant Intrathoracic Teratoma Presenting with Cachexia and Severe Dyspnea. Journal of Cardiothoracic Surgery, 14, Article No. 96. https://doi.org/10.1186/s13019-019-0922-y
[4]
Duwe, B.V., Sterman, D.H. and Musani, A.I. (2005) Tumors of the Mediasinum. Chest, 128, 2893-2909. https://doi.org/10.1378/chest.128.4.2893
[5]
Agrawal, T., Blau, A.J., Chwals, W.J. and Tischler, A.S. (2016) A Unique Case of Mediastinal Teratoma with Mature Pancreatic Tissue, Nesidioblastosis, and Aberrant Islet Differentiation: A Case Report and Literature Review. Endocrine Pathology, 27, 21-24. https://doi.org/10.1007/s12022-015-9393-4
[6]
Mohd, E.N., Mohd, R.A., Bakar, N.S., Mohd, K.M., Ismail, A.I. and Abdul, R.M. (2016) Cystic Teratoma Mimicking Recurrent Pleural Effusion, Complicated by Mycobacterium Abscessus Infection. Respirology Case Reports, 4, e00155.
https://doi.org/10.1002/rcr2.155
[7]
Razi, E., Imani, A., Ansari, I., Khamechian, T. and Davoodabadi, A. (2017) Pleural Effusion as a Rare Manifestation of Mediastinal Teratoma: A Case Report. Respiratory Medicine Case Reports, 22, 142-144. https://doi.org/10.1016/j.rmcr.2017.07.012
[8]
Takahashi, K. and Al-Janabi, N.J. (2010) Computed Tomography and Magnetic Resonance Imaging of Mediastinal Tumors. Journal of Magnetic Resonance Imaging, 32, 1325-1339. https://doi.org/10.1002/jmri.22377
[9]
Dhond, A.P., Agrawal, S.O., Sirmukaddam, S.V., Srinath, S., Roplekar, P. and Desai, P.R. (2016) Mediastinal teratoma: A Case Report with Review of Literature. Journal of the Scientific Society, 43, 57-59. https://doi.org/10.4103/0974-5009.175469
[10]
Yasa, K.P., Permana, A.A.C.T. and Dewi, S.M. (2020) Mediastinal Benign Mature Teratoma in Young Girl, Catastrophic Delayed and Complications of Surgery: A Case Report. Open Access Macedonian Journal of Medical Sciences, 8, 201-204.
https://doi.org/10.3889/oamjms.2020.3363
[11]
Abid, H., Neji, H., Haddar, S., Ammar, I., Ayadi, L., Msaad, S., et al. (2013) Mediastinal Mature Teratoma with Spontaneous Malignant Transformation. Revue des Maladies Respiratoires, 30, 424-428. https://doi.org/10.1016/j.rmr.2012.11.006
[12]
Beduneau, G., Cuvelier, A., Héliot, P., Métayer, J. and Muir, J.F. (2002) Mediastinal Teratoma with Recurrent Encysted Pleural Effusion. Revue des Maladies Respiratoires, 19, 367-370.
[13]
No, T.H., Seol, S.H., Seo, G.W., Kim, D.I., Yang, S.Y., Jeong, C.H., et al. (2015) Benign Mature Teratoma in Anterior Mediastinum. Journal of Clinical Medicine Research, 7, 726-728. https://doi.org/10.14740/jocmr2270w