Since the first report of COVID-19
in December 2019, our knowledge and treatment modalities haveevolved at great pace understanding
its impact on the maternal and neonatal outcomes. Whilst pregnant patients are not
more susceptible to acquiring the infection as compared to the general population,
they may be at higher risk of developing severe symptoms given the physiological
changes, relative immune-compromised state of pregnancy, and their neonates at risk
of consequent iatrogenic preterm deliveries. Our review article discusses outcomes
of pregnant women and neonates with COVID-19 from several countries including the
UK, USA, France, Italy and Chinaand provides a narrative review of literature from November 2019 till December
2020.
References
[1]
https://coronavirus.jhu.edu/map.html
[2]
Royal College of Obstetricians and Gynaecologists and the Royal College of Midwives (2020) Coronavirus (COVID-19) Infection in Pregnancy: Information for Healthcare Professionals. Royal College of Obstetricians and Gynaecologists.
https://www.rcog.org.uk/globalassets/documents/guidelines/2021-02-19-coronavirus-covid-19-infection-in-pregnancy-v13.pdf
[3]
Favre, G., Pomar, L., Musso, D. and Baud, D. (2020) 2019-nCoV Epidemic: What about Pregnancies? The Lancet, 395, e40.
https://doi.org/10.1016/S0140-6736(20)30311-1
[4]
LoMauro, A. and Aliverti, A. (2015) Respiratory Physiology of Pregnancy. Breathe, 11, 297-301. https://doi.org/10.1183/20734735.008615
[5]
Pierce-Williams, R.A.M., Burd, J., Felder, L., et al. (2020) Clinical Course of Severe and Critical COVID-19 in Hospitalized Pregnancies: A US Cohort Study. American Journal of Obstetrics & Gynecology MFM, 2, 100134.
https://doi.org/10.1016/j.ajogmf.2020.100134
[6]
(2020) More on Clinical Characteristics of Pregnant Women with Covid-19 in Wuhan, China. The New England Journal of Medicine, 383, 696-697.
https://doi.org/10.1056/NEJMc2016881
[7]
Martins, V., Calil, L.T., Lucia, V., Krebs, J., Brunow De Carvalho, W. (2020) Guidance on Breastfeeding during the Covid-19 Pandemic. Revista da Associação Médica Brasileira, 66, 541-546. https://doi.org/10.1590/1806-9282.66.4.541
[8]
Walker, K.F., O’Donoghue, K., Grace, N., Dorling, J., Comeau, J.L., Li, W. and Thornton, J.G. (2020) Maternal Transmission of SARS-Cov-2 to the Neonate, and Possible Route for Such Transmission: A Systematic Review and Critical Analysis. BJOG, 127, 1325-1336. https://doi.org/10.1111/1471-0528.16362
[9]
Liu, Y., Chen, H., Tang, K. and Guo, Y. (2020) Clinical Manifestations and Outcome of SARS-CoV-2 Infection during Pregnancy. Journal of Infection.
https://doi.org/10.1016/j.jinf.2020.02.028
[10]
Wu, Z. and McGoogan, J.M. (2020) Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72,314 Cases from the Chinese Centre for Disease Control and Prevention. JAMA, 323, 1239-1242. https://doi.org/10.1001/jama.2020.2648
[11]
Breslin, N., Baptiste, C., Gyamfi-Bannerman, C., Miller, R., Martinez, R., Bernstein, K., Ring, L., Landau, R., Purisch, S., Friedman, A.M., Fuchs, K., Sutton, D., Andrikopoulou, M., Rupley, D., Sheen, J.J., Aubey, J., Zork, N., Moroz, L., Mourad, M., Wapner, R., Simpson, L.L., D’Alton, M.E. and Goffman, D. (2020) Coronavirus Disease 2019 Infection among Asymptomatic and Symptomatic Pregnant Women: Two Weeks of Confirmed Presentations to an Affiliated Pair of New York City Hospitals. American Journal of Obstetrics & Gynecology MFM, 2, 100118.
https://doi.org/10.1016/j.ajogmf.2020.100118
[12]
Allotey, J., Stallings, E., Bonet, M., et al. (2020) Clinical Manifestations, Risk Factors, and Maternal and Perinatal Outcomes of Coronavirus Disease 2019 in Pregnancy: Living Systematic Review and Meta-Analysis. BMJ, 370, m3320.
https://doi.org/10.1136/bmj.m3320
[13]
Lokken, E.M., Walker, C.L., Delaney, S., Kachikis, A., Kretzer, N.M., Erickson, A., Resnick, R., Vanderhoeven, J., Hwang, J.K., Barnhart, N., Rah, J., McCartney, S.A., Ma, K.K., Huebner, E.M., Thomas, C., Sheng, J.S., Paek, B.W., Retzlaff, K., Kline, C.R., Munson, J., Blain, M., LaCourse, S.M., Deutsch, G. and Adams Waldorf, K.M. (2020) Clinical Characteristics of 46 Pregnant Women with a Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Washington State. American Journal of Obstetrics & Gynecology, 223, 911.E1-911.E14.
https://doi.org/10.1016/j.ajog.2020.05.031
[14]
Knight, M., Bunch, K., Vousden, N., Morris, E., Simpson, N., Gale, C., O’Brien, P., Quigley, M., Brocklehurst, P. and Kurinczuk, J.J., UK Obstetric Surveillance System SARS-CoV-2 Infection in Pregnancy Collaborative Group (2020) Characteristics and Outcomes of Pregnant Women Admitted to Hospital with Confirmed SARS-CoV-2 Infection in UK: National Population-Based Cohort Study. BMJ, 369, m2107. https://doi.org/10.1136/bmj.m2107
[15]
Blitz, M.J., Grünebaum, A., Tekbali, A., Bornstein, E., Rochelson, B., Nimaroff, M. and Chervenak, F. (2020) Intensive Care Unit Admissions for Pregnant and Non-Pregnant Women with Coronavirus Disease 2019. American Journal of Obstetrics & Gynecology, 223, Article 6465.
[16]
Kim, C.N.H., Hutcheon, J., van Schalkwyk, J. and Marquette, G. (2020) Maternal Outcomes of Pregnant Women Admitted to Intensive Care Units for Coronavirus Disease 2019. American Journal of Obstetrics & Gynecology, 223, 773-774.
[17]
Yan, J., Guo, J., Fan, C., Juan, J., Yu, X., Li, J., Feng, L., Li, C., Chen, H., Qiao, Y., Lei, D., Wang, C., Xiong, G., Xiao, F., He, W., Pang, Q., Hu, X., Wang, S., Chen, D., Zhang, Y., Poon, L.C. and Yang, H. (2020) Coronavirus Disease 2019 in Pregnant Women: A Report Based on 116 Cases. American Journal of Obstetrics & Gynecology, 223, 111.E1-111.E14. https://doi.org/10.1016/j.ajog.2020.04.014
[18]
Zimmermann, P. and Curtis, N. (2020) COVID-19 in Children, Pregnancy and Neonates: A Review of Epidemiologic and Clinical Features. The Pediatric Infectious Disease Journal, 39, 469-477. https://doi.org/10.1097/INF.0000000000002700
[19]
Khan, S., Jun, L., Nawsherwan, Siddique, R., Li, Y., Han, G., Xue, M., Nabi, G. and Liu, J. (2020) Association of COVID-19 with Pregnancy Outcomes in Health-Care Workers and General Women. Clinical Microbiology and Infectious, 26, 788-790.
https://doi.org/10.1016/j.cmi.2020.03.034
[20]
Zhang, L., Jiang, Y., Wei, M., Cheng, B.H., Zhou, X.C., Li, J., Tian, J.H., Dong, L. and Hu, R.H. (2020) [Analysis of the Pregnancy Outcomes in Pregnant Women with COVID-19 in Hubei Province]. Chinese Journal of Obstetrics and Gynecology, 55, 166-171. (In Chinese)
[21]
Yu, N., Li, W., Kang, Q., Xiong, Z., Wang, S., Lin, X., Liu, Y., Xiao, J., Liu, H., Deng, D., Chen, S., Zeng, W., Feng, L. and Wu, J. (2020) Clinical Features and Obstetric and Neonatal Outcomes of Pregnant Patients with COVID-19 in Wuhan, China: A Retrospective, Single-Centre, Descriptive Study. Lancet Infectious Diseases, 20, 559-564. https://doi.org/10.1016/S1473-3099(20)30176-6
[22]
Chen, H., Guo, J., Wang, C., Luo, F., Yu, X., Zhang, W., Li, J., Zhao, D., Xu, D., Gong, Q., Liao, J., Yang, H., Hou, W. and Zhang, Y. (2020) Clinical Characteristics and Intrauterine Vertical Transmission Potential of COVID-19 Infection in Nine Pregnant Women: A Retrospective Review of Medical Records. The Lancet, 395, 809-815. https://doi.org/10.1016/S0140-6736(20)30360-3
[23]
Panahi, L., Amiri, M. and Pouy, S. (2020) Risks of Novel Coronavirus Disease (COVID-19) in Pregnancy: A Narrative Review. Archives of Academic Emergency Medicine, 8, e34.
[24]
Khan, S., Peng, L., Siddique, R., Nabi, G., Nawsherwan, Xue, M., Liu, J. and Han, G. (2020) Impact of COVID-19 Infection on Pregnancy Outcomes and the Risk of Maternal-to-Neonatal Intrapartum Transmission of COVID-19 during Natural Birth. Infection Control & Hospital Epidemiology, 41, 748-750.
https://doi.org/10.1017/ice.2020.84
[25]
Peng, Z., Wang, J., Mo, Y., Duan, W., Xiang, G., Yi, M., Bao, L. and Shi, Y. (2020) Unlikely SARS-CoV-2 Vertical Transmission from Mother to Child: A Case Report. Journal of Infection and Public Health, 13, 818-820.
https://doi.org/10.1016/j.jiph.2020.04.004
[26]
Prabhu, M., Cagino, K., Matthews, K., Friedlender, R.L., Glynn, S.M., Kubiak, J.M., et al. (2020) Pregnancy and Postpartum Outcomes in a Universally Tested Population for SARS-COV-2 in New York City: A Prospective Cohort Study. BJOG, 127, 1548-1556. https://doi.org/10.1111/1471-0528.16403
[27]
Cheruiyot, I., Kipkorir, V., Ngure, B., Misiani, M., Munguti, J. and Ogeng’o, J. (2020) Arterial Thrombosis in Coronavirus Disease 2019 Patients: A Rapid Systematic Review. Annals of Vascular Surgery, 70, 273-281.
[28]
Nopp, S., Moik, F., Jilma, B., Pabinger, I. and Ay, C. (2020) Risk of Venous Thromboembolism in Patients with COVID-19: A Systematic Review and Meta-Analysis. Research and Practice in Thrombosis and Haemostasis, 4, 1178-1191.
https://doi.org/10.1002/rth2.12439
[29]
Mehan, A., Venkatesh, A. and Girish, M. (2020) COVID-19 in Pregnancy: Risk of Adverse Neonatal Outcomes. Journal of Medical Virology, 92, 2295-2297.
https://doi.org/10.1002/jmv.25959
[30]
Yang, Z., Wang, M., Zhu, Z. and Liu, Y. (2020) Coronavirus Disease 2019 (COVID-19) and Pregnancy: A Systematic Review. The Journal of Maternal-Fetal & Neonatal Medicine, 1-4. https://doi.org/10.1080/14767058.2020.1759541
[31]
Yang, H., Hu, B., Zhan, S., Yang, L.Y. and Xiong, G. (2020) Effects of SARS-CoV-2 Infection on Pregnant Women and Their Infants: A Retrospective Study in Wuhan, China. Archives of Pathology & Laboratory Medicine, 144, No. 10.
[32]
Tutiya, C.T., Siaulys, M.M., Kondo, M.M., Miglioli-Galvão, L., Galvão, E.C.A., Pinheiro, C.C., Torloni, M.R. and de Mello, F.B. (2020) Possible Formation of Pulmonary Microthrombi in the Early Puerperium of Pregnant Women Critically Ill with COVID-19: Two Case Reports. Version 2. Case Reports in Women’s Health, 27, e00237. https://doi.org/10.1016/j.crwh.2020.e00237
[33]
Shah, P.S., Diambomba, Y., Acharya, G., Morris, S.K. and Bitnun, A. (2020) Classification System and Case Definition for SARS-CoV-2 Infection in Pregnant Women, Fetuses, and Neonates. Acta Obstetricia et Gynecologica Scandinavica, 99, 565-568. https://doi.org/10.1111/aogs.13870
[34]
Wang, C., Zhou, Y.H., Yang, H.X. and Poon, L.C. (2020) Intrauterine Vertical Transmission of SARS-CoV-2: What We Know So Far. Ultrasound in Obstetrics & Gynecology, 55, 724-725. https://doi.org/10.1002/uog.22045
[35]
Masmejan, S., Pomar, L., Lepigeon, K., Favre, G., Baud, D. and Rieder, W. (2020) COVID-19 et Grossesse [COVID-19 and Pregnancy]. Revue Médicale Suisse, 16, 944-946.
[36]
Liu, W., Wang, J., Li, W., Zhou, Z., Liu, S. and Rong, Z. (2020) Clinical Characteristics of 19 Neonates Born to Mothers with COVID-19. Frontiers of Medicine, 14, 193-198. https://doi.org/10.1007/s11684-020-0772-y
[37]
Nayak, A.H., Kapote, D.S., Fonesca, M., Chavan, N., Mayenkar, R., Sarmalkar, M. and Bawa, A. (2020) Impact of Coronavirus Infection in Pregnancy: A Preliminary Study of 141 Patients. The Journal of Obstetrics and Gynecology of India, 70, 256-261. https://doi.org/10.1007/s13224-020-01335-3
